Results 71 to 80 of about 236,498 (264)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Eggshell waste bioprocessing for sustainable acid phosphatase production and minimizing environmental hazards

Journal of Biological Engineering
Background The Environmental Protection Agency has listed eggshell waste as the 15th most significant food industry pollution hazard. Using eggshell waste as a renewable energy source has been a hot topic recently.
Soad Abubakr Abdelgalil, Mohamed Mohamed Yousri Kaddah, Gaber Attia Abo-Zaid   +2 more
doaj   +1 more source

Evaluating the safety and efficacy of Lacticaseibacillus paracasei TISTR 2593 as a therapeutic probiotic for obesity prevention

Frontiers in Microbiology
Several recent studies have reported the potential of probiotics in reducing body weight and fat mass and improving glucose and lipid metabolism. Therefore, probiotic administration is considered an alternative approach for treating obesity.
Jaruwan Sitdhipol, Kanidta Niwasabutra, Neungnut Chaiyawan, Kamonsri Nuankham, Thanaphol Thanagornyothin, Somboon Tanasupawat, Wasaporn Preteseille Chanput, Pongsathon Phapugrangkul, Chaivarakun Chaipanya, Sukanya Phuengjayaem, Saranporn Poothong, Engkarat Kingkaew   +11 more
doaj   +1 more source

Research on the Impact of Scientific and Technological Talent Agglomeration on Green Development

Journal of Information Economics
With the intensification of the global ecological crisis, promoting green development has become a key path to achieve sustainable development. Based on the panel data of 30 provincial-level administrative regions in China from 2011 to 2022, this paper systematically examines the impact of scientific and technological talent agglomeration on regional ...
Yunqian Hu, Pu Hao
openaire   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Enhanced voltage generation in microbial fuel cells (MFCs) using bacterial isolates from seawater and industrial wastewater

Microbial Cell Factories
Background This study investigates the potential of microbial fuel cells (MFCs) for bioelectricity generation from seawater and wastewater sources. It focuses on the isolation, identification, and statistical optimization of electrogenic bacteria from ...
Ghada E. Hegazy, Nadia A. Soliman, Yasser R. Abdel-Fattah, Tarek H. Taha   +3 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Profile of Nursing research groups of the National Council for Scientific and Technological Development

Rev Rene, 2014
Nursing has been developing in the research field, therefore, it is important to be inserted into a research group of the National Council for Scientific and Technological Development, a funding agency that supports studies and strengthens the knowledge.
Costa, Andréia Cristina Barbosa, Chaves, Erika de Cássia Lopes, Terra, Fábio de Souza, Monteiro, Lidiane Aparecida   +3 more
openaire   +4 more sources