Results 51 to 60 of about 1,279,520 (308)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Streptomyces griseorubens as a microbial cell factory for extracellular uricase production and bioprocess optimization using statistical approach

Microbial Cell Factories
Background Uricase is a bio-drug used to reduce urate accumulation in gout disease. Thus, there is a continuous demand for screening soil samples derived from a variety of different sources in order to isolate a strain that possesses a high potential for
Noura El-Ahmady El-Naggar, Sara M. El-Ewasy, Nancy M. El-Shweihy   +2 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Roll force prediction using hybrid genetic algorithm with semi-supervised support vector regression

Journal of Electrical Systems and Information Technology
Roll force prediction plays a significant role in rolling schedule and optimization. For a specific steel grade, the roll force can be determined by the aid of several factors: rolling speed, initial thickness, ratio of thickness reduction, the starting ...
Shaheera Rashwan, Eman ElShenawy, Bayumy Youssef, Mohamed A. Abdou   +3 more
doaj   +1 more source

Thermal and Electrical Conductivity of Unsaturated Polyester Resin Filled with Copper Filler Composites

International Journal of Polymer Science, 2018
Thermal and electrical conductivity of unsaturated polyester resin with copper filler composite material are investigated both theoretically and experimentally.
Kemal Yaman, Özer Taga
doaj   +1 more source

THE STUDY OF THE PROPERTIES OF VULCANIZATES BASED ON ETHYLENE VINYL ACETATE RUBBERS WITH DIFFERENT CONTENT OF VINYL ACETATE UNITS

Тонкие химические технологии, 2018
The article studies the structure and properties of ethylene vinyl acetate rubbers and the influence of the vinyl acetate (VA) units content in the rubber on the technological, physical-mechanical, operating and electrical properties of vulcanizates. The
M. V. Syayleva, A. M. Bukanov, K. A. Zvezdenkov, V. N. Voloshin   +3 more
doaj   +1 more source

Software Reuse Methods to Improve Technological Infrastructure for e-Science [PDF]

, 2011
Social computing has the potential to contribute to scientific research. Ongoing developments in information and communications technology improve capabilities for enabling scientific research, including research fostered by social computing capabilities.
Downs, Robert R., Marshall, James J., Mattmann, Chris A.   +2 more
core   +1 more source

A. [PDF]

, 2004
O artigo procura analisar o contexto amplo do desenvolvimento científico e tecnológico que, ao mesmo tempo, torna possível e limita a produção do conhecimento em Ciências Sociais.
Brooks, David
core   +4 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source