Results 101 to 110 of about 4,153,632 (305)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Теория и практика судебной экспертизы, 2019 The article is devoted to the contribution review of forensic expertology scientific school created at the Department of Forensic Expertise of Kutafin Moscow State Law University (MSAL) under the leadership of professor E.R.
E. I. Galyashina
doaj +1 more source
‘Voyager’: An educational card game [PDF]
, 2003 ‘Voyager’ is an educational card game involving scientific satellites, developed for use in schools with children aged 9 to 13 years. The idea of the game is to improve pupils’ knowledge about the large number of scientific satellites there are in space ...
Smith, D R
core
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Personnel in the transition to the informational society: the experience of the department
Polylinguality and Transcultural Practices, 2011 The article deals the features of the personnel formation of the researchers in the media processes in the transition to the postindustrial society by the example of the department.
V V Matvienko
doaj
ESTABLISHMENT AND DEVELOPMENT OF SCIENTIFIC SCHOOL OF RAS ACADEMICIAN E.A. LUZHNIKOV
Неотложная медицинская помощь, 2017 The scientific school of the academician of the Russian Academy of Science E.A. Luzhnikov is the largest and most authoritative school in clinical toxicology in Russia, uniting about 150 scientists whose research continues and develops ideas, views and ...
M. S. Khubutiya +4 more
doaj +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Lifelong science learning [PDF]
, 2010 The author discusses the incorporation of lifelong learning in the study of science in New Zealand. He explains two preliminary thoughts related to the creation of a setting for lifelong learning in the field of science including the sustained enrichment
Barker, Miles
core
FEBS Open Bio, EarlyView.We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima +4 more
wiley +1 more source
TMC4 localizes to multiple taste cell types in the mouse taste papillae
FEBS Open Bio, EarlyView.Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata +6 more
wiley +1 more source