Results 41 to 50 of about 1,730,357 (294)

Exploring Scientific Application Performance Using Large Scale Object Storage

, 2018
One of the major performance and scalability bottlenecks in large scientific applications is parallel reading and writing to supercomputer I/O systems. The usage of parallel file systems and consistency requirements of POSIX, that all the traditional HPC
Chien, Steven Wei-der, Karim, Rami, Laure, Erwin, Markidis, Stefano, Narasimhamurthy, Sai   +4 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Cross-correlation of the 2XMMi catalogue with Data Release 7 of the Sloan Digital Sky Survey [PDF]

, 2010
The Survey Science Centre of the XMM-Newton satellite released the first incremental version of the 2XMM catalogue in August 2008 . With more than 220,000 X-ray sources, the 2XMMi was at that time the largest catalogue of X-ray sources ever published and
A. Schwope, Abazajian, Adelman-McCarthy, Alexander, Antonucci, Barcons, Barcons, Bochanski, Boller, Brusa, Budavári, C. Motch, Caccianiga, Caccianiga, Cappelluti, Carrera, Comaniciu, Comaniciu, Covey, Covey, De Ruiter, Della Ceca, Della Ceca, den Herder, Downes, F. Carrera, F.-X. Pineau, Gilli, Girardi, Guedel, Guillout, Güdel, Hands, Heckman, Jansen, Krumpe, L. Michel, Loaring, Luo, M. G. Watson, Mainieri, Mason, Motch, Motch, Motch, Oyabu, Perola, Ptak, R. Della Ceca, Reyes, Richards, Ritter, Rogel, Rutledge, S. Derrière, Sain, Schlegel, Schmidt, Schwope, Severgnini, Sinnott, Stephen, Stocke, Strauss, Strüder, Sung, Sutherland, Treister, Turner, Ueda, Vaiana, Vignali, Vignali, Véron-Cetty, Wang, Watson, Watson, Werner, Wolstencroft, Yanny, Zakamska, Zhang, Zickgraf   +82 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Closed to reason: time for accountability for the International Narcotic Control Board

Harm Reduction Journal, 2007
For more than two decades, the International Narcotic Control Board (INCB) has tried to stop harm reduction and its HIV prevention programs. This posture is based on a fundamental misunderstanding of their responsibilities and of drug addiction itself ...
Small Dan, Drucker Ernest
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A glance at the use of IRaMuTeQ® software in scientific research: a bibliometric study

Revista de Enfermagem da UFPI
Objective: To analyze and map the national and international scientific production on IRAMuTeQ® use software in scientific research in health in the historical series from 2012 to August 2022.
Dayara de Nazaré Rosa de Carvalho, Viviane Ferraz Ferreira de Aguiar, Daiane Baldo Apolinário, Dandara de Fátima Ribeiro Bendelaque, Luana Cunha Galvão Pereira, Simone Aguiar da Silva Figueira, Fabiana de Souza Orlandi   +6 more
doaj   +1 more source

BioWorkbench: A High-Performance Framework for Managing and Analyzing Bioinformatics Experiments [PDF]

, 2018
Advances in sequencing techniques have led to exponential growth in biological data, demanding the development of large-scale bioinformatics experiments.
Barbosa, Helio J. C., Foster, Ian, Gadelha Jr, Luiz M. R., Katz, Daniel S., Loss, Guilherme, Magalhães, Thiago, Mattoso, Marta, Mondelli, Maria Luiza, Ocaña, Kary, Vasconcelos, Ana Tereza R., Wilde, Michael   +10 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Unmanned Aerial Vehicles as Data Mules: An Experimental Assessment

IEEE Access, 2017
Communication in remote locations, specially in high-latitude regions, such as the Arctic, is challenged by the lack of infrastructures and by the limited availability of resources.
David Palma, Artur Zolich, Yuming Jiang, Tor Arne Johansen   +3 more
doaj   +1 more source