Results 31 to 40 of about 25,563 (307)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Extruded scintillator for the calorimetry applications [PDF]

, 2006
An extrusion line has been installed and successfully operated at FNAL (Fermi National Accelerator Laboratory) in collaboration with NICADD (Northern Illinois Center for Accelerator and Detector Development).
Pla-Dalmau, A., Rykalin, V., /NICADD, Dekalb, Beznosko, D., /Fermilab, /SUNY, Stony Brook, Dyshkant, A.   +6 more
core   +3 more sources

Gold Nanoparticles and Their Alternatives for Radiation Therapy Enhancement

Frontiers in Chemistry, 2014
Radiation therapy is one of the most commonly used treatments for cancer. The dose of delivered ionizing radiation can be amplified by the presence of high-Z materials via an enhancement of the photoelectric effect; the most widely studied material is ...
Daniel R. Cooper, Devesh eBekah, Jay eNadeau   +2 more
doaj   +1 more source

Fabrication and Characterization of K₂CeCl₅/⁶LiCl and CeCl₃/SrCl₂/⁶LiCl Eutectics for Thermal Neutron Detection

Crystals, 2022
In recent years, thermal neutron detection using scintillators has been used in a wide range of fields. Thus, the development of scintillators with a higher light yield, faster decay, and higher sensitivity for thermal neutrons is required. In this study,
Ryuga Yajima, Kei Kamada, Masao Yoshino, Yui Takizawa, Naoko Kutsuzawa, Rei Sasaki, Takahiko Horiai, Rikito Murakami, Kyoung Jin Kim, Vladimir V. Kochurikhin, Akihiro Yamaji, Shunsuke Kurosawa, Yuui Yokota, Hiroki Sato, Satoshi Toyoda, Yuji Ohashi, Takashi Hanada, Akira Yoshikawa   +17 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Inorganic scintillating materials and scintillation detectors

Proceedings of the Japan Academy, Series B, 2018
Scintillation materials and detectors that are used in many applications, such as medical imaging, security, oil-logging, high energy physics and non-destructive inspection, are reviewed. The fundamental physics understood today is explained, and common scintillators and scintillation detectors are introduced.
openaire   +3 more sources

PLASTIC SCINTILLATOR FOR RADIATION DOSIMETRY

, 2016
Inorganic scintillators, composed of high-atomic-number materials such as the CsI(Tl) scintillator, are commonly used in commercially available a silicon diode and a scintillator embedded indirect-type electronic personal dosemeters because the light ...
Yoo, Hyunjun, Lim, Kyung Taek, Kim, Jongyul, Moon, Myungkook, Kim, Chankyu, Cho, Gyuseong, Kim, Yewon   +6 more
core   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Effect of the Synthesis Conditions on the Morphology, Luminescence and Scintillation Properties of a New Light Scintillation Material Li₂CaSiO₄:Eu²⁺ for Neutron and Charged Particle Detection

Inorganics, 2022
In the present article, the influence of the activator concentration and impurity content of raw materials on the luminescence and scintillation properties of Li2CaSiO4 was studied. Polycrystalline powder material was obtained by the sol–gel method.
Ilia Komendo, Vitaly Mechinsky, Andrei Fedorov, Georgy Dosovitskiy, Victor Schukin, Daria Kuznetsova, Marina Zykova, Yury Velikodny, Mikhail Korjik   +8 more
doaj   +1 more source

Microstructural Evolution and Vacancy Defect Formation in Mn–Mo–Ni RPV Steel Under Low Cycle Fatigue: Insights From EBSD and PALS

Advanced Engineering Materials, EarlyView.
Low‐cycle fatigue damage in Mn–Mo–Ni reactor pressure vessel steel is examined using a combined electron backscatter diffraction and positron annihilation lifetime spectroscopy approach. The study correlates texture evolution, dislocation substructure development, and vacancy‐type defect formation across uniform, necked, and fracture regions, providing
Apu Sarkar, Dhanadeep Dutta, G. Bharat Reddy   +2 more
wiley   +1 more source