Results 31 to 40 of about 16,863 (293)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Low background scintillators to investigate rare processes

, 2020
International audienceMany developments, researches on innovative materials and purification techniques have offered a wide set of inorganic scintillators to investigate many processes; further developments are still in progress.
Marco, A.Di, Merlo, V., Tretyak, V.I., Danevich, F.A., Cerulli, R., Cappella, F., Kasperovych, D.V., Laubenstein, M., Shlegel, V.N., Kobychev, V.V., Barabash, A.S., Bernabei, R., Incicchitti, A., Belli, P., Poda, D.V., Polischuk, O.G., Caracciolo, V., Montecchia, F., Tretyak V I, Poda D V, Caracciolo V, Belli P, Polischuk O G, Merlo V, Cappella F, Danevich F A, Di Marco A, Incicchitti A, Cerulli R, Kasperovych D V, Bernabei R, Montecchia F, Shlegel V N, Kobychev V V, Laubenstein M, Barabash A S, A. Incicchitti, R. Cerulli, O.G. Polischuk, V.N. Shlegel, A. Di Marco, V. Caracciolo, F. Cappella, V. Merlo, R. Bernabei, M. Laubenstein, V.V. Kobychev, P. Belli, D.V. Kasperovych, A.S. Barabash, D.V. Poda, F.A. Danevich, V.I. Tretyak, F. Montecchia   +53 more
core   +2 more sources

Microstructural Evolution and Vacancy Defect Formation in Mn–Mo–Ni RPV Steel Under Low Cycle Fatigue: Insights From EBSD and PALS

Advanced Engineering Materials, EarlyView.
Low‐cycle fatigue damage in Mn–Mo–Ni reactor pressure vessel steel is examined using a combined electron backscatter diffraction and positron annihilation lifetime spectroscopy approach. The study correlates texture evolution, dislocation substructure development, and vacancy‐type defect formation across uniform, necked, and fracture regions, providing
Apu Sarkar, Dhanadeep Dutta, G. Bharat Reddy   +2 more
wiley   +1 more source

Polysiloxane-based scintillators as radiation sensors: state of the art and future perspectives

Frontiers in Sensors
Polysiloxane scintillators are emerging as promising radiation sensors due to their high radiation resistance, mechanical flexibility, chemical inertness, and thermal stability compared to traditional plastics.
Sara Maria Carturan, Sara Maria Carturan, Sandra Moretto, Sandra Moretto, Alberto Quaranta, Alberto Quaranta   +5 more
doaj   +1 more source

Comparative In Vitro Studies of Materials Properties of Uncoated and Multifunctional/Biocompatible Ultrananocrystalline Diamond (UNCD) Coated‐Bioactive Bovine Nanohydroxyapatite Scaffolds for Transformational Bone Tissue Engineering

Advanced Materials Interfaces, EarlyView.
Research/technology development demonstrated physicochemical/mechanical properties of transformational integration of hydroxyapatite (HAp) scaffolds and HAp scaffolds coated with a unique breakthrough biocompatible ultrananocrystalline diamond (UNCD) coating produced by microwave plasma chemical vapor deposition (MPCVD) process.
Angelica M. Castillo‐Paz, Leon R. Bernal‐Alvarez, Dorian F. Cañon‐Davila, Lerma H. Chan‐Chan, Orlando Auciello, Rafael Ramírez‐Bon, Mario E. Rodriguez‐Garcia   +6 more
wiley   +1 more source

Preparation and characterization of thermal neutron sensitive lithium doped polystyrene plastic scintillators

He jishu
BackgroundLithium-doped plastic scintillators possess the dual-mode detection capability for both fast and thermal neutrons, and combine the advantages of conventional plastic scintillators such as cost-effectiveness and the ability to fabricate in large
ZHANG Kaihui, LI Xiang, DENG Mingxue, SHI Yun, ZHOU Qi, WANG Ke, CHEN Junfeng   +6 more
doaj   +1 more source

Radioactive contamination of scintillators

, 2018
International audienceLow counting experiments (search for double β decay and dark matter particles, measurements of neutrino fluxes from different sources, search for hypothetical nuclear and subnuclear processes, low background α, β, γ spectrometry ...
V. I. Tretyak, Tretyak, V.I., F. A. Danevich, Danevich, F.A.   +3 more
core   +1 more source

Conformal Coating and Transfer of 2D Nanomaterials via Dynamic Interface Engineering

Advanced Materials Interfaces, EarlyView.
This review discusses conformal coating and transfer of two‐dimensional (2D) nanomaterials with a focus on dynamic interface engineering. By actively regulating nanosheet transport and interfacial contact during film formation, recent dynamic coating strategies overcome the limitations of conventional passive approaches and enable geometry‐adaptive ...
Seungyeon Kim, Euihoon Jeong, Seoung‐Ki Lee, Sukang Bae, Tae‐Wook Kim   +4 more
wiley   +1 more source

Advances in Halide Perovskites for Photon Radiation Detectors

Advanced Materials Technologies, EarlyView.
This work highlights recent progress in perovskite‐based photon radiation detectors, covering organic–inorganic hybrid, inorganic, lead‐free double, and vacancy‐ordered halide perovskites. Their detection performance is compared, material‐specific advantages and challenges are examined, and provides insight into current limitations and future ...
Liangling Wang, Jieqi Wang, Xiaojun Cui, Carsten Ronning   +3 more
wiley   +1 more source

Operando X‐Ray Micro‐Imaging Reveals Spatiotemporal Evolution of the Oxidation State of Nickel During Dry Methane Reforming

Angewandte Chemie, EarlyView.
Operando X‐ray micro‐imaging enables quantitative determination of spatially resolved nickel redox rates during the process of dry reforming of methane and its subsequent regeneration. The support composition governs the local nickel redox dynamics, thereby exhibiting different local nickel reduction and oxidation rates. The spatiotemporal Ni oxidation
Sofie Ferwerda, Valerie Briois, Anthony Beauvois, Sebastian Weber, Nils Bottke, Matteo Monai, Bert M. Weckhuysen   +6 more
wiley   +2 more sources