Results 81 to 90 of about 83,097 (278)

Suprachoroidal and Subretinal Injections of AAV Using Transscleral Microneedles for Retinal Gene Delivery in Nonhuman Primates. [PDF]

, 2020
Retinal gene therapy using adeno-associated viruses (AAVs) is constrained by the mode of viral vector delivery. Intravitreal AAV injections are impeded by the internal limiting membrane barrier, while subretinal injections require invasive surgery and ...
Chung, Sook Hyun, Mollhoff, Iris N, Nguyen, Uyen Tu, Noronha, Glenn, Taraborelli, Donna, Thomasy, Sara M, Yiu, Glenn, Yoo, Jesse   +7 more
core  

Understanding the spacing of placodes in the eye: A comparative study across age and species

The Anatomical Record, EarlyView.
Abstract The conjunctival placodes of the avian eye form in an intriguing and conserved sequence in a circular annulus around the cornea. These 13–16 placodes develop into papillae that are essential for inducing underlying intramembranous flat bones, known as scleral ossicles, which form an important part of the ocular skeleton.
Florence Joseph, Tamara A. Franz‐Odendaal   +1 more
wiley   +1 more source

Differential Regional Stiffening of Sclera by Collagen Cross-linking

Current Eye Research, 2019
Purpose: Corneal collagen cross-linking by ultraviolet light activation of riboflavin has been used clinically to enhance corneal stiffness. We sought to determine if cross-linking differentially affects scleral regions.
Bola A Gawargious, A. Le, Michael Lesgart, Shoaib Ugardar, J. Demer   +4 more
semanticscholar   +1 more source

The Dynamic Scleral Extracellular Matrix Alterations in Chronic Ocular Hypertension Model of Rats

Frontiers in Physiology, 2020
Intraocular pressure (IOP) generates stress and strains in the laminar cribrosa and sclera, which may affect the development and progression of glaucoma. Scleral stiffness and material components have changed under elevated IOP.
Chen Qiu, Chen Qiu, Chen Qiu, Jing Yao, Jing Yao, Jing Yao, Xi Zhang, Rong Zhang, Rong Zhang, Rong Zhang, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun, Shaohong Qian, Shaohong Qian, Shaohong Qian   +17 more
doaj   +1 more source

A Novel Slit Lamp‐Based System for 3D Ultrasound of the Eye

Journal of Ultrasound in Medicine, EarlyView.
Objectives This study aims to develop and evaluate a novel slit‐lamp‐based system to acquire 3‐dimensional (3D) ultrasound volumes using conventional ultrasound probes. Methods A slit‐lamp adapter was 3D printed and connected with a linear actuator and graphical user interface (GUI) system to control movement and create volumes of 2‐dimensional scans ...
Claire E. Malley, Joseph P. Miller, Boyan Pan, Josiah K. To, Jack O. Thomas, Steven Y. Chang, Jason Dagoon, William C. Tang, Parsa Riazi Esfahani, Andrew W. Browne   +9 more
wiley   +1 more source

Scoping Review of the development of artificial eyes throughout the years [PDF]

, 2016
Losing an eye following trauma can lead to profound psychosocial difficulties making it imperative for the wearer to be fitted with an aesthetically pleasing custom-made artificial eye.
Chinnery, H., Dyer, B., Noroozi, S., Thompson, S. B. N.   +3 more
core   +1 more source

Selective Equatorial Sclera Crosslinking in the Orbit Using a Metal-Coated Polymer Waveguide

Investigative Ophthalmology and Visual Science, 2019
Purpose Photochemical crosslinking of the sclera is an emerging technique that may prevent excessive eye elongation in pathologic myopia by stiffening the scleral tissue.
Sheldon J. J. Kwok, Sarah Forward, C. Wertheimer, A. Liapis, Harvey H. Lin, Moonseok Kim, T. Seiler, R. Birngruber, I. Kochevar, T. Seiler, S. Yun   +10 more
semanticscholar   +1 more source

A flexible arched artificial photoreceptor constructed by photodeformable liquid crystal polymers and its application in vision restoration

Smart Molecules, EarlyView.
A flexible arched artificial photoreceptor with high stability and biocompatibility was fabricated by integrating liquid crystal polymers with polyvinylidene fluoride‐trifluoroethylene. This device exhibits robust photoelectric responses under low‐intensity illumination and demonstrates efficacy in restoring visual responses in blind rats following ...
Yumeng Jiang, Bo Peng, Jinyu Ma, Feng Pan, Jia Wei, Lang Qin, Cheng Sun, Yanlei Yu   +7 more
wiley   +1 more source

Anterior Segment Optical Coherence Tomography Angiography Following Trabecular Bypass Minimally Invasive Glaucoma Surgery

Frontiers in Medicine, 2022
ObjectiveTo assess anterior segment optical coherence tomography angiography (AS-OCTA) imaging of the episcleral vessels before and after trabecular bypass minimally invasive glaucoma surgery (MIGS).DesignA prospective, clinical, single-centre, single ...
Jinyuan Gan, Chelvin C. A. Sng, Chelvin C. A. Sng, Mengyuan Ke, Chew Shi Chieh, Bingyao Tan, Bingyao Tan, Bingyao Tan, Leopold Schmetterer, Leopold Schmetterer, Leopold Schmetterer, Leopold Schmetterer, Leopold Schmetterer, Leopold Schmetterer, Leopold Schmetterer, Leopold Schmetterer, Marcus Ang, Marcus Ang   +17 more
doaj   +1 more source

Axial length, myopia progression, and myopic maculopathy in Stickler syndrome

Acta Ophthalmologica, EarlyView.
Abstract Purpose We lack knowledge on the potentially progressive nature of and the prevalence of complications to myopia as a characteristic trait of Stickler syndrome. Methods This cross‐sectional study combines ophthalmic examination and medical record data on Danish patients with genetically confirmed Stickler syndrome type 1 (COL2A1) and type 2 ...
Kirstine B. Boysen, Mette Bertelsen, Nanna D. Rendtorff, Stense Farholt, Line Kessel   +4 more
wiley   +1 more source