Results 61 to 70 of about 56,983 (273)
Disability and Rehabilitation, 2019 Purpose: The purpose of this study was to explore challenges faced by patients with systemic sclerosis, also called scleroderma, in coping with their disease and the strategies they used to face those challenges.
Katherine Milette +5 more
semanticscholar +1 more source
Arthritis &Rheumatology, EarlyView.Objective Two randomized trials for patients with diffuse systemic sclerosis (SSc) demonstrated an overall survival (OS) and event‐free survival (EFS) advantage of autologous hematopoietic stem cell transplantation (AHSCT) using CD34+ selected peripheral blood stem cells (PBSCs) compared with monthly cyclophosphamide (CY).
George E. Georges +16 more
wiley +1 more source
Targeting CD38-dependent NAD+ metabolism to mitigate multiple organ fibrosis
iScience, 2021 Summary: The processes underlying synchronous multiple organ fibrosis in systemic sclerosis (SSc) remain poorly understood. Age-related pathologies are associated with organismal decline in nicotinamide adenine dinucleotide (NAD+) that is due to ...
Bo Shi +20 more
doaj
Capillary regeneration in scleroderma: stem cell therapy reverses phenotype? [PDF]
PLoS ONE, 2008 Scleroderma is an autoimmune disease with a characteristic vascular pathology. The vasculopathy associated with scleroderma is one of the major contributors to the clinical manifestations of the disease.We used immunohistochemical and mRNA in situ ...
Jo N Fleming +12 more
doaj +1 more source
Arthritis &Rheumatology, EarlyView.Objective Little is known on the mechanisms necessary to maintain the physiologic adult human skin integrity. This study aims to quantitatively describe anatomic changes in systemic sclerosis (SSc)–skin compared with controls and investigate the underlying mechanisms.
Sara Chenguiti Fakhouri +18 more
wiley +1 more source
German guidelines for the diagnosis and therapy of localized scleroderma
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2016 Localized scleroderma designates a heterogeneous group of sclerotic skin disorders. Depending on the subtype, severity, and site affected, adjacent structures such as adipose tissue, muscles, joints, and bones may be involved.
A. Kreuter +11 more
semanticscholar +1 more source
Arthritis &Rheumatology, EarlyView.Objective To assess the value of serum type I interferon (IFN) score in predicting clinically meaningful progression in limited cutaneous systemic sclerosis (lcSSc) using a novel composite endpoint adopted from the MINIMISE clinical trial. Methods A retrospective, longitudinal lcSSc cohort was identified within a national, multicenter observational ...
Stefano Di Donato +9 more
wiley +1 more source
Immune Checkpoint Inhibitors and Scleroderma: Data from the European Pharmacovigilance Database
Drugs - Real World Outcomes, 2023 Background Immune checkpoint inhibitors (ICIs) can be commonly associated with the occurrence of immune-related adverse drug reactions (irADRs), which can involve any tissue and organ.
Maria Maddalena Nicoletti +8 more
doaj +1 more source
Epidemiology of scleroderma. [PDF]
Annals of the Rheumatic Diseases, 1991 The rarity of scleroderma makes it a difficult disorder to study epidemiologically. Recent studies have highlighted some of the environmental exposures associated with the disease. Among occupational exposures silica remains the most important, whereas appetite suppressants might be an important drug cause. The disease also appears to cluster in space,
openaire +5 more sources
Annals of the Rheumatic Diseases, 2010 Objectives To determine the causes and predictors of mortality in systemic sclerosis (SSc). Methods Patients with SSc (n=5860) fulfilling the American College of Rheumatology criteria and prospectively followed in the EULAR Scleroderma Trials and ...
A. Tyndall +46 more
semanticscholar +1 more source