Results 41 to 50 of about 2,393 (163)
Characteristics and outcomes of male participants in the Australian Scleroderma Cohort Study (ASCS).
Arthritis Care &Research, Accepted Article.Objective To determine the differences in demographic, serologic and clinical characteristics between male and female patients with systemic sclerosis (SSc) in an Australian cohort. Methods Retrospective observational study using data from the Australian Scleroderma Cohort Study (ASCS). Males (M) were compared to females (F) using chi‐squared, Wilcoxon
Emily Lin +14 more
wiley +1 more source
Arthritis Care &Research, Accepted Article.Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos +2 more
wiley +1 more source
Frontiers in Immunology, 2019 Systemic sclerosis is a profibrotic autoimmune disease mediated by the dysregulation of extracellular matrix synthesis. Formyl peptide receptor 2 (Fpr2) is a G protein-coupled receptor that modulates inflammation and host defense by regulating the ...
Gyu Tae Park +7 more
doaj +1 more source
Discordance between patient and physician global assessments in early systemic sclerosis
Arthritis Care &Research, Accepted Article.Objective This study aims to identify factors associated with patient and physician global assessments and discordance between them in systemic sclerosis (SSc). Methods Data from adults with early SSc (< 5 years) from the CONQUER registry were included.
Ellen Romich +35 more
wiley +1 more source
Advanced Science, EarlyView.This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia +5 more
wiley +1 more source
A case of scleroderma-like lesions as a cutaneous manifestation of carcinoid syndrome
Current Problems in Cancer: Case Reports, 2022 Scleroderma-like lesions are a rare sign of carcinoid syndrome which have been associated with poor prognosis. They differ from systemic sclerosis by involving preferentially the skin in the lower limbs, lacking Raynaud's phenomenon and having no ...
João Boavida Ferreira +5 more
doaj +1 more source
Arthritis &Rheumatology, EarlyView.Objective Mitochondria are organelles with a hypomethylated circular genome. Mitochondrial DNA (mtDNA) in the systemic circulation has been implicated in inflammation. This study investigates the role of circulating DNA in systemic sclerosis (SSc) and the cellular mechanisms governing its release.
Stavros Giaglis +9 more
wiley +1 more source
A review of recent studies on the pathogenesis of Systemic Sclerosis: focus on fibrosis pathways
Frontiers in ImmunologySystemic Sclerosis (SSc) is a systemic autoimmune disease of unknown etiology characterized by the development of frequently progressive cutaneous and internal organ fibrosis accompanied by severe vascular alterations.
Sergio A. Jimenez +3 more
doaj +1 more source
Gastrointestinal symptoms and motility disorders in patients with systemic scleroderma
BMC Gastroenterology, 2008 Background Studies on gastrointestinal symptoms, dysfunctions, and neurological disorders in systemic scleroderma are lacking so far. Methods Thirty-eight scleroderma patients (34 limited, 4 diffuse), 60 healthy controls and 68 dyspeptic controls were ...
Palasciano Giuseppe +6 more
doaj +1 more source
Egyptian Rheumatology and Rehabilitation, 2023 Background Systemic sclerosis is an autoimmune multisystem disorder which affects the patients’ physical and psychological functioning. Scleroderma health assessment questionnaire used to measure physical disability in systemic sclerosis patients.
Samah Mahmoud Alian +3 more
doaj +1 more source