Erectile dysfunction is frequent in systemic sclerosis and associated with severe disease: a study of the EULAR Scleroderma Trial and Research group [PDF]
, 2012 INTRODUCTION: Erectile dysfunction (ED) is common in men with systemic sclerosis (SSc) but the demographics, risk factors and treatment coverage for ED are not well known.
Smith, Vanessa +62 more
core +1 more source
Adipocyte-specific Repression of PPAR-gamma by NCoR Contributes to Scleroderma Skin Fibrosis
Arthritis Research & Therapy, 2018 Background A pivotal role for adipose tissue homeostasis in systemic sclerosis (SSc) skin fibrosis is increasingly recognized. The nuclear receptor PPAR-γ is the master regulator of adipogenesis.
Benjamin Korman +5 more
doaj +1 more source
From Localized Scleroderma to Systemic Sclerosis: Coexistence or Possible Evolution
Dermatology Research and Practice, 2018 Background. Systemic sclerosis (SSc) and localized scleroderma (LoS) are two different diseases that may share some features. We evaluated the relationship between SSc and LoS in our case series of SSc patients. Methods.
Giuggioli Dilia +5 more
doaj +1 more source
Localized scleroderma – current treatment options [PDF]
, 2017 Localized scleroderma (morphea) is a connective tissue disease that affects the skin, subcutaneous tissue and underlying tissues including the fasciae, muscles and bones. The treatment of localized scleroderma depends on the clinical form of the disease,
Małgorzata Michalska-Jakubus +2 more
core +1 more source
Rac Inhibition Reverses the Phenotype of Fibrotic Fibroblasts [PDF]
, 2009 Background: Fibrosis, the excessive deposition of scar tissue by fibroblasts, is one of the largest groups of diseases for which there is no therapy. Fibroblasts from lesional areas of scleroderma patients possess elevated abilities to contract matrix ...
Christopher P Denton +26 more
core +1 more source
Exploring Sources of Emotional Distress among People Living with Scleroderma: A Focus Group Study. [PDF]
PLoS ONE, 2016 BACKGROUND:Systemic sclerosis, or scleroderma, is a chronic and rare connective tissue disease with negative physical and psychological implications. Sources of emotional distress and the impact they have on the lives of people with scleroderma are not ...
Stephanie T Gumuchian +13 more
doaj +1 more source
Fibrosing arthropathy in juvenile scleroderma
Современная ревматология, 2021 The group of scleroderma diseases includes a number of clinical entities, the main symptom of which is skin tightening. Scleroderma is a prominent example of these diseases, characterized by excessive synthesis and deposition of collagen in organs and ...
D. A. Dibrov +2 more
doaj +1 more source
Treatment Algorithms for Systemic Sclerosis According to Experts [PDF]
, 2018 OBJECTIVE: There is a lack of agreement regarding treatment for many aspects of systemic sclerosis (SSc). We undertook this study to generate SSc treatment algorithms endorsed by a high percentage of SSc experts.
Walker KM +4 more
core +3 more sources
Scleroderma as paraneoplastic disease: A new case of a rare association with renal cell carcinoma [PDF]
, 2021 Scleroderma as paraneoplastic disease: A new case of a rare association with renal cell ...
Ruffilli, Francesca +5 more
core +1 more source
Arthritis Research & Therapy, 2017 Background Prokinetics are used to treat enteric dismotility symptoms in systemic sclerosis (SSc) patients, but they often lack adequate efficacy. The most effective prokinetics belonging to the serotonin (5-HT4) receptor agonists class were withdrawn ...
Barbara Vigone +8 more
doaj +1 more source