Results 11 to 20 of about 56,955 (209)

Checkpoint Inhibitor-Associated Scleroderma and Scleroderma Mimics [PDF]

Pharmaceuticals, 2023
Immune checkpoint inhibitors (ICI) are the standard of care for various malignancies and have been associated with a wide spectrum of complications that are phenotypically akin to primary autoimmune diseases.
Michael Macklin, Sudeep Yadav, Reem Jan, Pankti Reid   +3 more
doaj   +3 more sources

Development of the optimal touchscreen interface for patients with scleroderma [PDF]

, 2021
Impaired hand function is a major contributor to overall disability and reduced health-related quality of life in scleroderma patients. A relevant issue concerns interaction of scleroderma subjects with touchscreen interfaces.
Germani M., Filippini E., Cesaretti G., Papetti A., Maurizi V., Moroncini G., Gabrielli A., Gesuita R., Brunzini A.   +8 more
core   +1 more source

Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients [PDF]

, 2001
Patients with scleroderma receiving Iloprost as a treatment for severe Raynaud's phenomenon report a reduction in skin tightness, suggesting that this drug inhibits skin fibrosis.
Stratton, R, Thomas Haberberger, Carol M. Black, Haberberger, T, Xu Shiwen, Martini, G, Holmes, A, Alan Holmes, Andrew Leask, Shiwen, X, David Abraham, Black, CM, Leask, A, Martin, GR, Abraham, D, George R. Martin, Richard Stratton, Giorgia Martini   +17 more
core   +1 more source

Hand disease in scleroderma: a clinical correlate for chronic hand transplant rejection [PDF]

, 2013
Chronic rejection remains a potential long-term consequence of hand composite tissue allotransplantation (CTA). Scleroderma has already been proposed as a model for chronic facial allograft rejection based on potential parallels of observed progression ...
Puri, A, Butler, PE, Clarke, A, Amin, K; id_orcid, Amin, K, Sivakumar, B, Denton, C   +6 more
core   +1 more source

Renal perfusion in scleroderma patients assessed by microbubble-based contrast-enhanced ultrasound [PDF]

, 2012
OBJECTIVES: Renal damage is common in scleroderma. It can occur acutely or chronically. Renal reserve might already be impaired before it can be detected by laboratory findings.
Himsel, Andrea, Kleinert, Stefan, Roll, Petra, Baumgärtner, Christian, Burkhardt, Harald, Tony, Hans-Peter, Janett, Manfred, Müller, Adelheid, Baumgaertner, Christian, Jenett, Manfred, Fleck, Martin, Feuchtenberger, Martin, Mueller, Adelheid   +12 more
core   +1 more source

Global gene expression analysis of systemic sclerosis myofibroblasts demonstrates a marked increase in the expression of multiple NBPF genes

Scientific Reports, 2021
Myofibroblasts are the key effector cells responsible for the exaggerated tissue fibrosis in Systemic Sclerosis (SSc). Despite their importance to SSc pathogenesis, the specific transcriptome of SSc myofibroblasts has not been described.
Giuseppina Abignano, Heidi Hermes, Sonsoles Piera-Velazquez, Sankar Addya, Francesco Del Galdo, Sergio A. Jimenez   +5 more
doaj   +1 more source

Pharmacological Inhibition of Toll-Like Receptor-4 Signaling by TAK242 Prevents and Induces Regression of Experimental Organ Fibrosis

Frontiers in Immunology, 2018
Systemic sclerosis (SSc) is a poorly understood heterogeneous condition with progressive multi-organ fibrosis. Recent genetic and genomic evidence suggest a pathogenic role for dysregulated innate immunity and toll-like receptor (TLR) activity in SSc ...
Swati Bhattacharyya, Wenxia Wang, Zenshiro Tamaki, Bo Shi, Anjana Yeldandi, Yasuhiro Tsukimi, Masashi Yamasaki, John Varga   +7 more
doaj   +1 more source

Advanced Autoantibody Testing in Systemic Sclerosis

Diagnostics, 2023
Systemic sclerosis is a systemic autoimmune rheumatic disease characterized by immune abnormalities, leading to vasculopathy and fibrosis. Autoantibody testing has become an increasingly important part of diagnosis and prognostication.
Kholoud Almaabdi, Zareen Ahmad, Sindhu R. Johnson   +2 more
doaj   +1 more source

A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis. [PDF]

, 2015
In scleroderma (systemic sclerosis, SSc), persistent activation of myofibroblast leads to severe skin and organ fibrosis resistant to therapy. Increased mechanical stiffness in the involved fibrotic tissues is a hallmark clinical feature and a cause of ...
Ayuko Takahashi (789901), Barbara D. Smith (2212672), Takahashi, A, Christopher Denton, Layne, MD, Bahja Ahmed-Abdi, Ayuko Takahashi, Suki, B, Nikitorowicz-Buniak, J, Bela Suki (2212681), Bahja Ahmed-Abdi (2212675), Matthew D. Layne (364786), Markella Ponticos, Ahmed-Abdi, B, Robert Lafyatis, Markella Ponticos (2212669), Xu Shiwen (2212678), Stratton, R, Bela Suki, Barbara D Smith, Richard Stratton (776213), Joanna Nikitorowicz-Buniak (776212), Smith, BD, Christopher Denton (276245), Xu Shiwen, Lafyatis, R, David Abraham (36404), Shiwen, X, David Abraham, Abraham, D, Matthew D Layne, Ponticos, M, Denton, C, Joanna Nikitorowicz-Buniak, Robert Lafyatis (38139), Richard Stratton   +35 more
core   +1 more source

Localized scleroderma: clinical spectrum and therapeutic update [PDF]

Anais Brasileiros de Dermatologia, 2015
Scleroderma is a rare connective tissue disease that is manifested by cutaneous sclerosis and variable systemic involvement. Two categories of scleroderma are known: systemic sclerosis, characterized by cutaneous sclerosis ...
Mariana Figueiroa Careta, Ricardo Romiti
doaj   +2 more sources