Results 11 to 20 of about 2,393 (163)
Frontiers in Immunology, 2018 Systemic sclerosis (SSc) is a poorly understood heterogeneous condition with progressive multi-organ fibrosis. Recent genetic and genomic evidence suggest a pathogenic role for dysregulated innate immunity and toll-like receptor (TLR) activity in SSc ...
Swati Bhattacharyya +7 more
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Localized scleroderma: clinical spectrum and therapeutic update [PDF]
Anais Brasileiros de Dermatologia, 2015 Scleroderma is a rare connective tissue disease that is manifested by cutaneous sclerosis and variable systemic involvement. Two categories of scleroderma are known: systemic sclerosis, characterized by cutaneous sclerosis ...
Mariana Figueiroa Careta, Ricardo Romiti
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Checkpoint Inhibitor-Associated Scleroderma and Scleroderma Mimics
Pharmaceuticals, 2023 Immune checkpoint inhibitors (ICI) are the standard of care for various malignancies and have been associated with a wide spectrum of complications that are phenotypically akin to primary autoimmune diseases.
Michael Macklin +3 more
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From Localized Scleroderma to Systemic Sclerosis: Coexistence or Possible Evolution
Dermatology Research and Practice, 2018 Background. Systemic sclerosis (SSc) and localized scleroderma (LoS) are two different diseases that may share some features. We evaluated the relationship between SSc and LoS in our case series of SSc patients. Methods.
Giuggioli Dilia +5 more
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Adipocyte-specific Repression of PPAR-gamma by NCoR Contributes to Scleroderma Skin Fibrosis
Arthritis Research & Therapy, 2018 Background A pivotal role for adipose tissue homeostasis in systemic sclerosis (SSc) skin fibrosis is increasingly recognized. The nuclear receptor PPAR-γ is the master regulator of adipogenesis.
Benjamin Korman +5 more
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Exploring Sources of Emotional Distress among People Living with Scleroderma: A Focus Group Study. [PDF]
PLoS ONE, 2016 BACKGROUND:Systemic sclerosis, or scleroderma, is a chronic and rare connective tissue disease with negative physical and psychological implications. Sources of emotional distress and the impact they have on the lives of people with scleroderma are not ...
Stephanie T Gumuchian +13 more
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Fibrosing arthropathy in juvenile scleroderma
Современная ревматология, 2021 The group of scleroderma diseases includes a number of clinical entities, the main symptom of which is skin tightening. Scleroderma is a prominent example of these diseases, characterized by excessive synthesis and deposition of collagen in organs and ...
D. A. Dibrov +2 more
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Scleroderma with crescentic glomerulonephritis: a case report
Journal of Medical Case Reports, 2008 Introduction Systemic sclerosis or scleroderma is an autoimmune rheumatic disease characterized by organ-based fibrosis. Renal involvement in scleroderma occurs mainly in the form of scleroderma renal crisis, affecting 5 to 10% of patients.
Ramaswami Arunachalam +8 more
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Arthritis Research & Therapy, 2017 Background Prokinetics are used to treat enteric dismotility symptoms in systemic sclerosis (SSc) patients, but they often lack adequate efficacy. The most effective prokinetics belonging to the serotonin (5-HT4) receptor agonists class were withdrawn ...
Barbara Vigone +8 more
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Immunoregulatory Role of HLA-G in Allergic Diseases
Journal of Immunology Research, 2016 Allergic diseases are sustained by a T-helper 2 polarization leading to interleukin-4 secretion, IgE-dependent inflammation, and mast cell and eosinophil activation.
Giuseppe Murdaca +4 more
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