Scleroderma of geriatric age and scleroderma-like paraneoplastic syndrome – description of two cases [PDF]
, 2016 Systemic sclerosis (Ssc) is an autoimmune connective tissue disease of unknown origin, characterized by progressive fibrosis of the skin and internal organs.
Robert Rudny, Magdalena Marek
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Scleroderma Renal Crisis as Initial Presentation of Scleroderma [PDF]
, 2022 Scleroderma renal crisis (SRC) is characterized by the development of severe or worsening arterial hypertension associated with the abrupt onset of progressive renal failure in the absence of any other cause.
Bhavna Bansal +4 more
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Scleroderma Defiance: A Practical, Educational and Free Guide for Self-Management of Scleroderma [PDF]
, 2023 Scleroderma is a rare and incurable autoimmune disease characterized by overproduction of collagen, which often leads to organ damage and sclerotic tissue.
Flanagan, Magen +1 more
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The role of Borrelia burgdorferi infection in scleroderma [PDF]
, 2014 Borrelia burgdorferi , a Gram-negative, spiral-shaped bacterium transmitted to humans via tick bites, is the etiologic agent of borreliosis (Lyme disease) with diverse clinical manifestations. There are several types of pathological lesions in the course
Żaneta Smoleńska +3 more
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Scleroderma with crescentic glomerulonephritis: a case report
Journal of Medical Case Reports, 2008 Introduction Systemic sclerosis or scleroderma is an autoimmune rheumatic disease characterized by organ-based fibrosis. Renal involvement in scleroderma occurs mainly in the form of scleroderma renal crisis, affecting 5 to 10% of patients.
Ramaswami Arunachalam +8 more
doaj +1 more source
Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts [PDF]
, 2004 The endothelins are a family of endothelium-derived peptides that possess a variety of functions, including vasoconstriction. Endothelin-1 (ET-1) is up-regulated during tissue repair and promotes myofibroblast contraction and migration, hence ...
Abraham, DJ +34 more
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Immunoregulatory Role of HLA-G in Allergic Diseases
Journal of Immunology Research, 2016 Allergic diseases are sustained by a T-helper 2 polarization leading to interleukin-4 secretion, IgE-dependent inflammation, and mast cell and eosinophil activation.
Giuseppe Murdaca +4 more
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Dermatology Online Journal, 2003 A 72-year-old man with diabetes-associated scleredema is presented. The patient had a long history of diabetes mellitus that had been difficult to control with complications of retinopathy, nephropathy, and arteriosclerosis leading to myocardial infarcts and stroke.
openaire +4 more sources
Histological Changes of Linear Scleroderma “en Coup de Sabre” [PDF]
, 2014 Introduction. Scleroderma is a chronic disease of unknown aetiology characterized by skin fibrosis and is divided into two clinical entities: localized scleroderma and systemic sclerosis.
Tophuria D. +3 more
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Immune Checkpoint Inhibitors and Scleroderma: Data from the European Pharmacovigilance Database
Drugs - Real World Outcomes, 2023 Background Immune checkpoint inhibitors (ICIs) can be commonly associated with the occurrence of immune-related adverse drug reactions (irADRs), which can involve any tissue and organ.
Maria Maddalena Nicoletti +8 more
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