Results 71 to 80 of about 80,483 (293)

Differences in IgG Sialylation Distinguish Asymptomatic from Symptomatic Anti‐Nuclear Antibody Positive Individuals

Arthritis &Rheumatology, Accepted Article.
Objective The transition from asymptomatic anti‐nuclear antibody (ANA) positivity to systemic autoimmune rheumatic disease (SARD) is associated with increased production of pro‐inflamamtory factors such as TNF‐α. Here we investigate whether the relative absence of inflammation in asymptomatic ANA+ individuals (ANA+NS) results from a lack of circulating
Carolina Muñoz‐Grajales, Carmen C. Ucciferri, Sindhu R. Johnson, Zahi Touma, Zareen Ahmad, Dennisse Bonilla, Linda T. Hiraki, Arthur Bookman, Joan E. Wither   +8 more
wiley   +1 more source

A review of recent studies on the pathogenesis of Systemic Sclerosis: focus on fibrosis pathways

Frontiers in Immunology
Systemic Sclerosis (SSc) is a systemic autoimmune disease of unknown etiology characterized by the development of frequently progressive cutaneous and internal organ fibrosis accompanied by severe vascular alterations.
Sergio A. Jimenez, Fabian A. Mendoza, Fabian A. Mendoza, Sonsoles Piera-Velazquez   +3 more
doaj   +1 more source

Natural Formulations: Novel Viewpoint for Scleroderma Adjunct Treatment

Journal of Immunology Research, 2021
Background. Scleroderma is a complex disease involving autoimmune, vascular, and connective tissues, with unknown etiology that can progress through any organ systems. Objective.
Shirin Assar, Hosna Khazaei, Maryam Naseri, Fardous El-Senduny, Saeideh Momtaz, Mohammad Hosein Farzaei, Javier Echeverría   +6 more
doaj   +1 more source

Evaluation of estimated glomerular filtration rate and clinical variables in systemic sclerosis patients [PDF]

, 2016
Objectives: The most important renal complication of systemic sclerosis (SSc) is scleroderma renal crisis (SRC). Many patients demonstrate less severe renal complications, most likely associated with reduced renal blood flow and a consequent reduction in
Amoroso, Antonio, Barbano, Biagio, Cianci, Rosario, Gigante, Antonietta, Granata, Guido, Quarta, Silvia, Rosato, Edoardo, Salsano, Felice   +7 more
core   +1 more source

B cells and systemic sclerosis interstitial lung disease

Arthritis &Rheumatology, Accepted Article.
Interstitial lung disease is an important complication of systemic sclerosis (SSc‐ILD) with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to FDA‐approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of interstitial lung diseases of other systemic autoimmune ...
Nina Goldman, Voon Ong, Christopher Denton   +2 more
wiley   +1 more source

Statins and the vasculopathy of systemic sclerosis: potential therapeutic agents? [PDF]

, 2006
It has been postulated that endothelial cell injury is the initiating event in the pathogenesis of systemic sclerosis, causing attraction, attachment, migration and infiltration of activated T-cells and subsequent production of cytokines and growth ...
Derk, Chris T., Jimenez, Sergio A.
core   +2 more sources

Laboratory Practices for the Detection and Characterization of Cryoglobulins and Cryofibrinogen

Journal of Clinical Laboratory Analysis, EarlyView.
This study shows the importance of carrying out the search for both cryoproteins, cryoglobulins, and cryofibrinogen in cases of strong clinical suspicion of cryoproteinemia, despite their complex but not impossible detection. Use of correct procedures from the pre‐preanalytical phase up to reporting, of alternative methods such as immunotyping and the ...
Teresa Troiano, Anna Marinaccio, Pamela Patierno, Alessandra Di Geronimo, Lucia Demarinis, Francesca Di Serio   +5 more
wiley   +1 more source

Porto‐sinusoidal vascular disorder in a pediatric patient with prolidase deficiency: A case report

JPGN Reports, EarlyView.
Abstract Prolidase deficiency (PD) is a rare autosomal recessive disorder affecting collagen turnover, leading to diverse clinical manifestations including dermatologic lesions, hepatosplenomegaly, and vascular anomalies. Liver involvement in PD is poorly understood, with few reported cases.
Melissa Castro, Christian Martinez, Carole Brathwaite, Reuven Bromberg, Ana M. Rodriguez, Erick Hernandez   +5 more
wiley   +1 more source

Cultural adaptation and validation of the scleroderma health assessment questionnaire into Arabic language

Egyptian Rheumatology and Rehabilitation, 2023
Background Systemic sclerosis is an autoimmune multisystem disorder which affects the patients’ physical and psychological functioning. Scleroderma health assessment questionnaire used to measure physical disability in systemic sclerosis patients.
Samah Mahmoud Alian, Enass Abdel-kader Eliwa, Sohair Atia Ahmed, Manar Ibrahim Abd El-Fattah Ibrahim   +3 more
doaj   +1 more source

Prognostic impact of coronary microcirculation abnormalities in systemic sclerosis: a prospective study to evaluate the role of non-invasive tests [PDF]

, 2013
INTRODUCTION: Microcirculation dysfunction is a typical feature of systemic sclerosis (SSc) and represents the earliest abnormality of primary myocardial involvement.
CAULI, ALBERTO, Garau P, Iliceto S, MATHIEU, ALESSANDRO, MELONI, LUIGI, MONTISCI, ROBERTA, PIGA, MATTEO, Ruscazio M, Siotto P, VACCA, ALESSANDRA   +9 more
core   +1 more source