Results 111 to 120 of about 11,032 (258)
Systemic sclerosis disease modification clinical trials design: quo vadis? [PDF]
, 2012 The purpose of this manuscript is to discuss relevant aspects of clinical trials for Systemic Sclerosis (SSc) and to identify important considerations for the design of SSc disease modification clinical trials.
Jimenez, Sergio A. +2 more
core +2 more sources
Mapping the Tissue‐of‐Origins of Mesenchymal Stromal Cells in Injury Repair
Advanced Science, Volume 13, Issue 3, 14 January 2026.This study maps mesenchymal stromal cells (MSCs) across multiple tissues, revealing that bone marrow–derived MSCs mobilize monocytes via CCL2 to promote systemic inflammation but do not migrate to distant organs to form fibrotic or tumor stroma. Instead, local MSCs dominate tissue remodeling, suggesting a “two‐hit” model linking systemic inflammation ...
Xinyu Thomas Tang +4 more
wiley +1 more source
French recommendations for the management of systemic sclerosis
Orphanet Journal of Rare Diseases, 2021 Systemic sclerosis (SSc) is a generalized disease of the connective tissue, arterioles, and microvessels, characterized by the appearance of fibrosis and vascular obliteration.
Eric Hachulla +31 more
doaj +1 more source
Clinical Case Reports, Volume 14, Issue 1, January 2026.ABSTRACT This case of antiphospholipid syndrome, Evans syndrome, and anti‐Scl‐70 positivity (suggesting early SSc) showed marked symptom improvement with rituximab, but poor prognosis persists. Highlights the need for early diagnosis of overlapping autoimmunity, SSc complication monitoring, and optimized immunotherapy in complex cases.
Chunhua Cao +4 more
wiley +1 more source
Systemic Sclerosis and Hyperthyroidism in Pregnancy [PDF]
, 2013 Systemic sclerosis (SSc) is a connective tissue disease affecting women of childbearing age at least five times more than men. For a long time, pregnant women with SSc have high morbidity and mortality based on case reports and case series.
Awalia, A. (Awalia) +2 more
core
Wnt Signaling Pathway: Biological Function, Diseases, and Therapeutic Interventions
MedComm, Volume 7, Issue 1, January 2026.The Wnt signaling pathway is essential for development and tissue homeostasis, while its dysregulation drives diverse diseases. This review systematically outlines its components, functions, regulators, and preclinical models, highlighting secreted frizzled‐related proteins (SFRPs) as context‐dependent, biphasic modulators.
Xiaoyu Jin +3 more
wiley +1 more source
A Unique Presentation of Anti-RNA Polymerase III Positive Systemic Sclerosis Sine Scleroderma
Case Reports in Rheumatology, 2016 Systemic sclerosis is a rare autoimmune disorder with a wide spectrum of clinical manifestations and a multitude of autoantibodies that are associated with it.
Cody M. Lee +4 more
doaj +1 more source
Respirology Case Reports, Volume 14, Issue 1, January 2026.We report the case of a patient with anti‐eIF2B‐positive SSc‐ILD managed with stepwise mycophenolate titration and subsequent nintedanib addition, accompanied by serial biomarkers and clinical follow‐up to help delineate the therapeutic course within this rare serological phenotype.
Hiro Ikeda +3 more
wiley +1 more source
Erectile dysfunction is frequent in systemic sclerosis and associated with severe disease: a study of the EULAR Scleroderma Trial and Research group [PDF]
, 2012 Introduction: Erectile dysfunction (ED) is common in men with systemic sclerosis (SSc) but the demographics, risk factors and treatment coverage for ED are not well known.
Abdel Atty Mohamed, Walid A. +24 more
core
The Journal of Dermatology, Volume 53, Issue 1, Page 41-53, January 2026.ABSTRACT Systemic sclerosis is an autoimmune disease characterized by vasculopathy, fibrosis, and immune dysregulation. Anti‐SS‐A antibodies (anti‐SSA) have been reported to confer severe clinical manifestations in some Western and Japanese cohorts. We aimed to determine whether anti‐SSA seropositivity affects clinical outcomes in Japanese patients. We
Nana Ishida +4 more
wiley +1 more source