Results 81 to 90 of about 11,032 (258)

Systemic sclerosis: current views of its pathogenesis. [PDF]

, 2003
Systemic sclerosis (SSc) is an autoimmune disorder of unknown etiology characterized by severe and often progressive cutaneous and visceral fibrosis, pronounced alterations in the microvasculature, and numerous cellular and humoral immune abnormalities ...
Derk, Chris T., Jimenez, Sergio A.
core   +2 more sources

Antibody‐Empowered Nanomedicine for Precise Biomedical Applications

Advanced Science, EarlyView.
This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen, Xinglin Chen, Zhenhao Gao, Meng Sun, Yaozong Yu, Fang Lv, Qiujun Wang, Jinfeng Zhang   +7 more
wiley   +1 more source

Scleroderma renal crisis in a case of mixed connective tissue disease

Saudi Journal of Kidney Diseases and Transplantation, 2014
Mixed connective tissue disease (MCTD) is an overlap syndrome first defined in 1972 by Sharp et al. In this original study, the portrait emerged of a connective tissue disorder sharing features of systemic lupus erythematosus, systemic sclerosis ...
Mukul Vij, Vinita Agrawal, Manoj Jain
doaj   +1 more source

Case report of systemic sclerosis: Uncommon manifestation of nephrotic syndrome post-renal crisis

SAGE Open Medical Case Reports, 2023
Kidney involvement in systemic sclerosis occurs in about 20% of cases, with scleroderma renal crisis as a significant complication. However, cases of glomerular disease with massive proteinuria are rare.
Ai Fujii, Takaya Kondo, Yasutaka Katsura, Sho Kumano, Serina Kita, Kazutoshi Nomura, Tomohisa Yabe, Norifumi Hayashi, Keiji Fujimoto, Hitoshi Yokoyama, Kengo Furuichi   +10 more
doaj   +1 more source

Validation of potential classification criteria for systemic sclerosis [PDF]

, 2012
Objective Classification criteria for systemic sclerosis (SSc; scleroderma) are being updated jointly by the American College of Rheumatology and European League Against Rheumatism.
Aletaha, Avouac, Bohan, Bohan, Classification and Response Criteria Subcommittee of the American College of Rheumatology Committee on Quality Measures, Dougados, Dougados, Felson, Ferri, Fletcher, Fransen, Goetz, Hachulla, Hochberg, Hudson, Johnson, Johnson, Johnson, Kuwana, LeRoy, Lonzetti, Low, Maricq, Masi, Nadashkevich, Nadashkevich, Pepe, Peschken, Punglia, Spiegelhalter, Steen, Streiner, Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee, Tan, Tuffanelli, Walker, Winterbauer, Wollheim   +37 more
core   +1 more source

Mucosal‐Associated Invariant T Cells in Rheumatic Diseases

Arthritis &Rheumatology, EarlyView.
Mucosal‐associated invariant T (MAIT) cells are innate‐like T cells defined by their semi‐invariant T cell receptor and restriction by the major histocompatibility complex class I–related molecule (MR1). These cells are primarily activated by microbial‐derived metabolites presented by MR1 or by cytokines.
Manon Lesturgie‐Talarek, Virginie Gonzalez, Lucie Beaudoin, Noémie Sénot, Corinne Miceli‐Richard, Yannick Allanore, Agnès Lehuen, Jerôme Avouac   +7 more
wiley   +1 more source

Value of systolic pulmonary arterial pressure as a prognostic factor of death in the systemic sclerosis EUSTAR population. [PDF]

, 2015
The aim of this study was to assess the prognostic value of systolic pulmonary artery pressure (sPAP) estimated by echocardiography in the multinational European League Against Rheumatism Scleroderma Trial and Research (EUSTAR) cohort.Data for patients ...
C. M., Mihai, C. P., Denton, D., Launay, E., Hachulla, G., Cuomo, G., Riemekasten, M. R., Pozzi, M., Matucci Cerinic, M., Sarraco, O., Distler, on behalf of the EUSTAR co, Workers, P. E., Carreira, P., Airò, P., Caramaschi, P., Clerson, Riccieri, Valeria, Rosato, Edoardo, S., Rednic, S., Ullman, S., Zeni, U. A., Walker, U., Müller Ladner, V., Smith, Y., Allanore   +23 more
core   +1 more source

Case‐Based Immunology: B Cells and Systemic Sclerosis Interstitial Lung Disease

Arthritis &Rheumatology, EarlyView.
Interstitial lung disease (ILD) is an important complication of systemic sclerosis (SSc), with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to US Food and Drug Administration–approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of ILDs of other systemic autoimmune
Nina Goldman, Voon Ong, Christopher P. Denton   +2 more
wiley   +1 more source

Association of Abatacept With Lower Mortality Risk Compared to Rituximab in Rheumatoid Arthritis–Associated Interstitial Lung Disease: An Emulated Target Trial

Arthritis &Rheumatology, EarlyView.
Objective The optimal treatment strategy for rheumatoid arthritis–associated interstitial lung disease (RA‐ILD) remains uncertain, and direct comparative data between biologics are limited. This study aimed to evaluate the effectiveness and safety of abatacept compared with rituximab in patients with RA‐ILD.
Po‐Cheng Shih, Shiow‐Ing Wang, Qing‐Wen Wang, James Cheng Chung Wei   +3 more
wiley   +1 more source

Incidences and Risk Factors of Organ Manifestations in the Early Course of Systemic Sclerosis: A Longitudinal EUSTAR Study [PDF]

, 2016
Objective Systemic sclerosis (SSc) is a rare and clinically heterogeneous autoimmune disorder characterised by fibrosis and microvascular obliteration of the skin and internal organs.
Adler, S, Airò, P, Allanore, Y, Ananieva, L, Ancuta, CM, Balbir Gurman, A, Branimir, A, Carreira, PE, Codullo, V, Corrado, A, Couto, M, Cozzi, F, Czirjak, L, Damjanov, N, De Langhe, E, Del Galdo, F, Denton, C, Distler, JHW, Distler, O, Engelhart, M, EUSTAR co-authors, Eyerich, K, Farge, D, Foti, R, Gabrielli, A, Garcia de la Pena Lefebvre, P, Guiducci, S, Hachulla, E, Hasler, P, Hassanien, M, Heitmann, S, Henes, J, Hesselstrand, R, Hunzelmann, N, Jaeger, VK, Kahl, S, Kayser, C, Koehm, M, Kowal-Bielecka, O, Krasowska, D, Krummel-Lorenz, B, Kucharz, EJ, Lapadula, G, Li, M, Limonta, M, Litinsky, I, Lo Monaco, A, Loyo, E, Mallia, C, Mariok, E, Martinovic, D, Mathieu, A, Matucci-Cerinic, M, Midtvedt, O, Mihai, C, Mouthon, L, Müller-Ladner, U, Novak, S, Opris, D, Paola, C, Pellerito, R, Posa, M, Radim, B, Radominski, SC, Rednic, S, Ricci, M, Riccieri, V, Riemekasten, G, Rosato, E, Rossbach, P, Rozman, B, Saketkoo, LA, Sampaio-Barros, PD, Sancho, JJA, Santamaria, VO, Scorza, R, Seidel, M, Selmi, C, Sibilia, J, Smith, V, Solanki, K, Stamenkovic, B, Stamp, L, Stebbings, S, Sunderkotter, C, Szmyrka-Kaczmarek, M, Tarner, IH, Tikly, M, Ullman, S, Uprus, M, Vanthuyne, M, Veale, D, Vettori, S, von Muhlen, A, Walker, UA, Wigley, F, Wirz, EG, Yavuz, S, Zenone, T   +98 more
core   +9 more sources