Results 31 to 40 of about 6,713,973 (267)

Single‐Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients

Advanced Science, EarlyView.
scRNA sequencing reveals distinct tumor ecosystem features in CAYA‐PTC, marked by enriched CD4T_Tfh, CD8T_Tex cells, and rapid malignant thyrocyte differentiation (absent of mild‐state BRAF‐like population) toward invasive states. Prominent emCAF_LAMP5 populations interact with endothelial cells and thyrocytes facilitate angiogenesis and metastasis ...
Kai Guo, Lingyi Yang, Zirui Huang, Kai Qian, Yuan Shi, Mengjia Fei, Yuan Feng, Zixian Chen, Ming Qiu, Linglin Tang, Anqi Li, Zhibao Lv, Jiangbin Liu, Zhou Chen, Kuiran Dong, Zhuoying Wang   +15 more
wiley   +1 more source

Human Hepatobiliary Organoids: Recent Advances in Drug Toxicity Verification and Drug Screening

Biomolecules
Many drug and therapeutic modalities have emerged over the past few years. However, successful commercialization is dependent on their safety and efficacy evaluations.
Haoyu Fang, Haoying Xu, Jiong Yu, Hongcui Cao, Lanjuan Li   +4 more
doaj   +1 more source

Tendinopathy: The Interplay between Mechanical Stress, Inflammation, and Vascularity

Advanced Science, EarlyView.
This review explores the complex and self‐reinforcing cycle of mechanical stress, inflammation, and altered vascularity in tendinopathy—a common, painful tendon disorder. It integrates current findings on cellular, molecular, and biomechanical mechanisms, highlighting how mechanical overload, inflammatory signals, and abnormal blood vessel behavior ...
Renate Gehwolf, Herbert Tempfer, Nevra Pelin Cesur, Andrea Wagner, Andreas Traweger, Christine Lehner   +5 more
wiley   +1 more source

TWEAK promotes peritoneal inflammation [PDF]

, 2014
Peritoneal dialysis (PD) is complicated by peritonitis episodes that cause loss of mesothelium and eventually sclerosing peritonitis. An improved understanding of the molecular contributors to peritoneal injury and defense may increase the therapeutic ...
Alberto Ortiz, Ana Belen Sanz, Beatriz Santamaria, Gloria del Peso, Jesus Egido, Jose Jimenez-Heffernan, Luis Miguel Blanco-Colio, Luiz Stark Aroeira, Manuel Lopez-Cabrera, Maria Dolores Sanchez-Niño, Marta Ruiz-Ortega, Marta Ruiz-Ortega, Rafael Selgas, Teresa Bellon   +13 more
core   +4 more sources

Association Between Distance to the Transplant Center and Survival Following Living Donor Liver Transplantation

Annals of Gastroenterological Surgery, EarlyView.
This study investigated the impacts of distance to transplant center on posttransplant survival following LDLT. Patients living further away from the transplant center had worse graft and patient survival rates than those of patients living closer, probably due to less frequency of follow‐up visits, and living > 40 miles from our treatment center was ...
Hajime Matsushima, Akihiko Soyama, Takanobu Hara, Ayaka Kinoshita, Takashi Hamada, Kazushige Migita, Ayaka Satoh, Hajime Imamura, Tomohiko Adachi, Susumu Eguchi   +9 more
wiley   +1 more source

Oral vancomycin solution is superior to capsule in inducing clinical biomarker and endoscopic remission in children with atypical ulcerative colitis

British Journal of Clinical Pharmacology, EarlyView.
Aims Atypical colitis (presenting reverse gradient colitis, backwash ileitis or rectal sparing) is associated with primary sclerosing cholangitis–ulcerative colitis (PSC). Oral vancomycin has been used to manage paediatric atypical colitis with/without confirmed PSC. Different preparations had shown different efficacy.
Laura Räisänen, Fariha Balouch, Claire Reilly, Christopher Burgess, Peter Lewindon   +4 more
wiley   +1 more source

Treatment of chronic mandibular dislocations by eminectomy : follow-up of 10 cases and literature review [PDF]

, 2009
Introduction: Temporomandibular joint (TMJ) dislocation is defined as an excessive forward movement of the condyle beyond the articular eminence, with complete separation of the articular surfaces and fixation in that position.
Cavalcanti do Egito Vasconcelos, Belmiro, Neto, José Pacheco Martins Ribeiro, Porto, Gabriela Granja, Vasconcelos, César Freire de Melo   +3 more
core   +1 more source

Think highly of immunoglobulin G4‐related chronic rhinosinusitis as a clinical entity in immunoglobulin G4‐related disease

Eye &ENT Research, EarlyView.
Abstract IgG4‐related chronic rhinosinusitis (IgG4‐related CRS) is gaining recognition among various specialized physicians. As a systemic disease involving multiple organs, IgG4‐related CRS is still not widely recognized as an independent clinical entity. Given the complexity of diagnosing autoimmune‐related multisystem diseases, early recognition and
Lianqi Wan, Luo Zhang, Yingshi Piao, Yuan Zhang   +3 more
wiley   +1 more source

Autophagy: A cyto-protective mechanism which prevents primary human hepatocyte apoptosis during oxidative stress [PDF]

, 2012
The role of autophagy in the response of human hepatocytes to oxidative stress remains unknown. Understanding this process may have important implications for the understanding of basic liver epithelial cell biology and the responses of hepatocytes ...
Biederbick A, Christopher J. Weston, David H. Adams, Munafo´ DB, Ricky H. Bhogal, Schroedl C, Simon C. Afford, Stuart M. Curbishley   +7 more
core   +1 more source

Mid‐term survival in patients awaiting heart and kidney transplantation with Impella 5.5 support

ESC Heart Failure, EarlyView.
Abstract Background Patients with end‐stage heart failure and chronic kidney disease requiring dual‐organ transplantation (DOT) face significant challenges in utilizing durable mechanical circulatory support due to the risks associated with renal replacement therapies (RRTs) and multi‐organ failure.
Smruti Desai, Smit Paghdar, Jose Ruiz, Ji‐Min Jang, Sharan Malkani, Daniel S. Yip, Juan Leoni, Jose Nativi, Basar Sareyyupoglu, Kevin Landolfo, Si Pham, Parag Patel, Rohan Goswami   +12 more
wiley   +1 more source