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Human Hepatobiliary Organoids: Recent Advances in Drug Toxicity Verification and Drug Screening

Biomolecules
Many drug and therapeutic modalities have emerged over the past few years. However, successful commercialization is dependent on their safety and efficacy evaluations.
Haoyu Fang +4 more
doaj +1 more source

TWEAK promotes peritoneal inflammation [PDF]

, 2014
Peritoneal dialysis (PD) is complicated by peritonitis episodes that cause loss of mesothelium and eventually sclerosing peritonitis. An improved understanding of the molecular contributors to peritoneal injury and defense may increase the therapeutic ...
Alberto Ortiz +13 more
core +8 more sources

Oral vancomycin solution is superior to capsule in inducing clinical biomarker and endoscopic remission in children with atypical ulcerative colitis

British Journal of Clinical Pharmacology, EarlyView.
Aims Atypical colitis (presenting reverse gradient colitis, backwash ileitis or rectal sparing) is associated with primary sclerosing cholangitis–ulcerative colitis (PSC). Oral vancomycin has been used to manage paediatric atypical colitis with/without confirmed PSC. Different preparations had shown different efficacy.
Laura Räisänen +4 more
wiley +1 more source

Building a Robust Investigator‐Initiated Platform: The I‐CARE Experience

Clinical Pharmacology &Therapeutics, EarlyView.
Investigator‐initiated studies that include information collected by patients are rising, but limited data is available on patient and investigator experience in this setting. The I‐CARE cohort included patients with inflammatory bowel disease (IBD) monthly collecting clinical information in 15 countries for up to 6 years.
Julien Kirchgesner +906 more
wiley +1 more source

Deceptive Thyroid Pathologies: Anaplastic Thyroid Carcinoma Mimics and Clinical Implications

Head &Neck, EarlyView.
ABSTRACT Background Beyond follicular‐derived thyroid carcinomas, lymphomas, and metastatic disease, there are rare pathologies of the thyroid gland that represent a challenge. We report patients with unusual malignancies that mimic similar aggressive cancers. Methods Retrospective case series.
David Z. Allen +12 more
wiley +1 more source

Pediatric liver transplantation [PDF]

, 1987
Liver transplantation, which once was an experimental procedure of no practical interest, has become the preferred treatment for infants and children dying of almost all non-neoplastic end-stage liver diseases. Liver replacement is being provided by many
Esquivel, C, Gordon, R, Starzl, TE, Todo, S +3 more
core

Encapsulating peritoneal sclerosis [PDF]

, 2009
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/OpenThe incidence of encapsulating peritoneal sclerosis in patients on peritoneal dialysis seems to be increasing worldwide.
Fjölnir Elvarsson +5 more
core

Evaluation of four chatbots in autoimmune liver disease: A comparative analysis

Annals of Hepatology
Introduction and Objectives: Autoimmune liver diseases (AILDs) are rare and require precise evaluation, which is often challenging for medical providers. Chatbots are innovative solutions to assist healthcare professionals in clinical management.
Jimmy Daza +15 more
doaj +1 more source

Bioengineered Bile Duct for Liver Regenerative Medicine and Bile Duct Reconstruction

JGH Open
Bioengineered tubular bile ducts are an emerging strategy in liver regenerative medicine and extrahepatic bile duct reconstruction, offering potential solutions to address biliary diseases and improve outcomes in liver transplantation.
Peilin Li, Di Huang, Weili Gu, Yi Gao, Yu Huang +4 more
doaj +1 more source

Autophagy: A cyto-protective mechanism which prevents primary human hepatocyte apoptosis during oxidative stress [PDF]

, 2012
The role of autophagy in the response of human hepatocytes to oxidative stress remains unknown. Understanding this process may have important implications for the understanding of basic liver epithelial cell biology and the responses of hepatocytes ...
Biederbick A +7 more
core +1 more source

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