Results 31 to 40 of about 3,490 (218)
Human Hepatobiliary Organoids: Recent Advances in Drug Toxicity Verification and Drug Screening
BiomoleculesMany drug and therapeutic modalities have emerged over the past few years. However, successful commercialization is dependent on their safety and efficacy evaluations.
Haoyu Fang +4 more
doaj +1 more source
Bioengineered 3D hPSC‐Cholangiocyte Ducts With Physiological Signals for Biliary Disease Modeling
Advanced Healthcare Materials, EarlyView.Tian and colleagues generated a bioengineered bile duct from human pluripotent stem cell (hPSC)‐derived intrahepatic cholangiocytes within a high‐throughput, 384‐well platform to systematically examine the influence of biliary physiological signals including fluid flow, stromal cells and bile acids, and models intrahepatic biliary disease progression ...
Britney Tian +10 more
wiley +1 more source
, 2013 Benjamin Phillips, MD, FACS, has joined the Division of Colon and Rectal Surgery. Dr. Phillips completed residency training in 2005 at University of Tennessee Medical Center in Knoxville and fellowship training in colorectal surgery in 2009 at Jefferson.
core +8 more sources
Animal Models and Experimental Medicine, EarlyView.Our study demonstrated that a single bilateral intra‐testicular injection of 50% dextrose (Group A) and 20% mannitol (Group B) solutions cannot serve as chemical sterilizing agents in male rabbits. However, intra‐testicular injection of 0.9% saline (Group C) significantly reduced the seminiferous tubule quality (STQ), seminiferous tubule maturity (STM),
Mohammad‐Javad Gholizadeh +2 more
wiley +1 more source
Autophagy: A cyto-protective mechanism which prevents primary human hepatocyte apoptosis during oxidative stress [PDF]
, 2012 The role of autophagy in the response of human hepatocytes to oxidative stress remains unknown. Understanding this process may have important implications for the understanding of basic liver epithelial cell biology and the responses of hepatocytes ...
Biederbick A +7 more
core +1 more source
TWEAK promotes peritoneal inflammation [PDF]
, 2014 Peritoneal dialysis (PD) is complicated by peritonitis episodes that cause loss of mesothelium and eventually sclerosing peritonitis. An improved understanding of the molecular contributors to peritoneal injury and defense may increase the therapeutic ...
Alberto Ortiz +13 more
core +8 more sources
Arthritis &Rheumatology, EarlyView.Objective To evaluate the risk of intrahepatic cholestasis of pregnancy (ICP) in azathioprine (AZA)–exposed versus unexposed systemic lupus erythematosus (SLE) pregnancies within the multicenter prospective Lupus in Pregnancy (LEGACY) cohort. Methods LEGACY is conducted at Systemic Lupus International Collaborating Clinics in Canada, South Korea, Peru,
Reem Farhat +14 more
wiley +1 more source
Pediatric liver transplantation [PDF]
, 1987 Liver transplantation, which once was an experimental procedure of no practical interest, has become the preferred treatment for infants and children dying of almost all non-neoplastic end-stage liver diseases. Liver replacement is being provided by many
Esquivel, C +3 more
core
British Journal of Clinical Pharmacology, EarlyView.Aims Atypical colitis (presenting reverse gradient colitis, backwash ileitis or rectal sparing) is associated with primary sclerosing cholangitis–ulcerative colitis (PSC). Oral vancomycin has been used to manage paediatric atypical colitis with/without confirmed PSC. Different preparations had shown different efficacy.
Laura Räisänen +4 more
wiley +1 more source
Evaluation of four chatbots in autoimmune liver disease: A comparative analysis
Annals of HepatologyIntroduction and Objectives: Autoimmune liver diseases (AILDs) are rare and require precise evaluation, which is often challenging for medical providers. Chatbots are innovative solutions to assist healthcare professionals in clinical management.
Jimmy Daza +15 more
doaj +1 more source