Results 101 to 110 of about 922,760 (302)
Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND). a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension [PDF]
, 2018 Background: Although several disease-modifying treatments are available for relapsing multiple sclerosis, treatment effects have been more modest in progressive multiple sclerosis and have been observed particularly in actively relapsing subgroups or ...Achiron, Anat, Airas, Laura, Al Khedr, Abdullatif, Alvarez Cermeño, Jose Carlos, Arnold, Douglas L, Ayuso, Guillermo Izquierdo, Bandari, Daniel, Bartholomé, Emmanuel, Baum, Karl, Bergamaschi, Roberto, Berger, Joseph, Berthele, Achim, Bhan, Virender, Blevins, Gregg, Boyko, Alexey, Brassat, David, Brochet, Bruno, Brunet, Donald, Cadavid, Diego, Camac, Ann, Campbell, Nolan, Camu, William, Chang, Ih, Chefranova, Zanna, Cohan, Stanley, Comi, Giancarlo, Conway, Jill, Cottone, Salvatore, Czarnecki, Maciej, D'Hooghe, Marie, Debouverie, Marc, Devonshire, Virginia, Deykin, Aaron, Drozdowski, Wieslaw, Duddy, Martin, Dufek, Michal, Duquette, Pierre, Edwards, Keith, Elovaara, Irina, Eralinna, Juha-Pekka, Escartin, Antonio, Evdoshenko, Evgeny, Fabian, Michelle, Faiss, Juergen, Fernandez, Oscar Fernandez, Flachenecker, Peter, Florin, Jack, Forrestal, Fiona, Frederiksen, Jette, Freedman, Mark, Freedman, Mark S, Freedman, Steven, Frequin, Stephan, Fryze, Waldemar, Gairin, Xavier Montalban, Garcia-Merino, Antonio, Garwacki, Dennis, Goldman, Myla, Goldman, Myla D, Gran, Bruno, Grand'Maison, François, Grimaldi, Luigi, Gunnarsson, Martin, Hardiman, Orla, Harrison, Daniel, Harrower, Timothy, Hartung, Hans-Peter, Havrdová, Eva Kubala, Havrdová, Eva Kubala, Hernandez Perez, Miguel Angel, Herrman, Craig, Hertmanowska, Hanka, Ho, Pei-Ran, Hobart, Jeremy, Hohlfeld, Reinhard, Huang, Deren, Hupperts, Raymond, Ilkowski, Jan, Jacques, François, Javed, Adil, Jeffery, Douglas, Jeffery, Douglas, Kamin, Stephen, Kaminska, Anna, Kanovsky, Petr, Kant, Matthias, Kapoor, Raju, Kapoor, Raju, Karussis, Dimitrios, Katsamakis, George, Khabirov, Farit, Khatri, Bhupendra, Killestein, Joep, Klodowska-Duda, Gabriela, Krumbholz, Markus, Lallana, José Meca, Langer-Gould, Annette, Lapierre, Yves, Laplaud, David, Lassek, Christoph, Lebrun Frenay, Christine, Lee, Liesly, Lee, Martin, Lucas, Nisha, Lycke, Jan, Lynch, Sharon, Maciejowski, Maciej, Maeurer, Mathias, Mancardi, Giovanni Luigi, Martin, Claes, Massacesi, Luca, Mattison, Paul, Mattson, David, Mcguigan, Christopher, Meuth, Sven, Mikol, Dan, Miller, Aaron, Miller, Tamara, Miravalle, Augusto, Morra, Vincenzo Brescia, Morrow, Sarah, Moses, Harold, Motta, Ewa, Muley, Suraj, Napier, James, Nicholas, Richard, Nielsen, Allen, Nocentini, Ugo, Oreja-Guevara, Celia, Pachner, Andrew, Pandolfo, Massimo, Pardo, Gabriel, Pearson, Owen, Pelletier, Jean, Petersen, Thor, Picone, Maryann, Piehl, Fredrik, Podemski, Ryszard, Potemkowski, Andrzej, Rashid, Waqar, Ravnborg, Mads, Robertson, Derrick, Rog, David, Rog, Teresa, Roshanisefat, Homayoun, Royal, Walter, Saiz Hinarejos, Albert, Salvetti, Marco, Sarasoja, Taneli, Scarpini, Elio, Schrijver, Hans, Sellebjerg, Finn, Sellebjerg, Finn, Selmaj, Krzysztof, Sharrack, Basil, Sheppard, Christopher, Silber, Eli, Sivertseva, Stella, Sola, Patrizia, Steiner, Deborah, Stelmasiak, Zbigniew, Stepien, Adam, Stetkarova, Ivana, Sundstrom, Peter, Talabova, Marika, Tedeschi, Gioacchino, Thrower, Ben, Trojano, Maria, Turner, Ben, Tutaj, Andrzej, Twyman, Cary, Van Dijl, Ronald, van Munster, Erik, Van Wijmeersch, Bart, Vermersch, Patrick, Vukusi, Sandra, Waubant, Emmanuelle, Wendt, Jeanette, Williams, Anna, Woolmore, John, Yadav, Vijayshree, Yakupov, Eduard, Yeung, Michael, Young, Carolyn, Yu, Bei, Zabad, Rana, Zaborski, Jacek, Zaffaroni, Mauro, Zarelli, Greg, Ziemssen, Tjalf +189 morecore +3 more sourcesBrainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction
Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding +8 morewiley +1 more sourceFunctional connectivity changes and their relationship with clinical disability and white matter integrity in patients with relapsing-remitting multiple sclerosis [PDF]
, 2015 Background and objective: To define the pathological substrate underlying disability in multiple sclerosis by evaluating the relationship of resting-state functional connectivity with microstructural brain damage, as assessed by diffusion tensor maging ...Filippini, N, Pantano, Patrizia, Petsas, Nikolaos, Piattella, MARIA CRISTINA, Pozzilli, Carlo, Prosperini, Luca, Sbardella, Emilia, Tona, Francesca, Upadhyay, Neeraj +8 morecore +1 more sourceNeuroinflammation in GAD65 Antibody‐Associated Epilepsy Measured Using [18F]DPA‐714 PET/MRI
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT
The timing for initiating immunotherapy in patients with glutamic acid decarboxylase 65 (GAD65) antibody‐associated epilepsy is a challenge. We used the translocator protein radioligand [18F]DPA‐714 and PET to evaluate brain microglial activation.Jingjing Chen, Yuying Zhang, Heyu Zhang, Jinming Zhang, Ningning Wang, Xintong Guo, Yicong Liu, Yue Liu, Xiangsong Zhang, Ziyi Chen, Guanzhong Ni +10 morewiley +1 more sourceThe Unyielding Enigma
Journal of Indian Academy of Oral Medicine and RadiologyScleroderma, an autoimmune connective tissue disorder marked by profound fibrosis in visceral organs, skin, and blood vessels, exhibits oral manifestations typically initiating with tongue rigidity and facial skin alterations. It presents with a plethora Hima John, Jiss Mary, Jeslin James, S Devu +3 moredoaj +1 more sourceValue of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective
To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods
A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators +26 morewiley +1 more sourceBAFF Index and CXCL13 levels in the cerebrospinal fluid associate respectively with intrathecal IgG synthesis and cortical atrophy in multiple sclerosis at clinical onset [PDF]
, 2017 Background
B lymphocytes are thought to play a relevant role in multiple sclerosis (MS) pathology. The in vivo analysis of intrathecally produced B cell-related cytokines may help to clarify the mechanisms of B cell recruitment and ...Ermani, M., Federle, L., Gallo, P., Miante, S., Perini, P., Poggiali, D., Pravato, S., Puthenparampil, M., Rinaldi, F., Ruggero, S., Toffanin, E., Zito, Alberto +11 morecore +1 more sourceFeasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background
Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method
This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen +19 morewiley +1 more source