Results 251 to 260 of about 1,097,866 (354)

Therapeutic Outcomes of Fingolimod and Interferon Beta-1a in Relapsing-Remitting Multiple Sclerosis: A Real-World Study from Jordan. [PDF]

Medicina (Kaunas)
Al Anber A, Abu Al Karsaneh O, Abuquteish D, Abdallah O, Issa MA, Sa'adeh M, Kilani D.   +6 more
europepmc   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

Advanced Science, EarlyView.
Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera, Lena Kühn, Lisa Jungbluth, Verian Bader, Laura J. Krause, David Kartte, Elias Adriaenssens, Sascha Martens, Jörg Tatzelt, Carsten Sachse, Konstanze F. Winklhofer   +10 more
wiley   +1 more source

Liver Cirrhosis With Encapsulating Peritoneal Sclerosis: A Case Report. [PDF]

Cureus
Boudreau E, Matte R, Wilke C.
europepmc   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Shagreen Patch in Tuberous Sclerosis Complex at High-Frequency Ultrasound. [PDF]

Diagnostics (Basel)
Tagliati C, Wortsman X.
europepmc   +1 more source

Postural sway in multiple sclerosis patients

Kozinc, Žiga, Žura, Eva, Brecl Jakob, Gregor   +2 more
openalex   +1 more source

Interaction between Th17 and central nervous system in multiple sclerosis

Song Lai, Xiaomin Wu, Yue Liu, Bo Liu, Huiling Wu, Kongyang Ma   +5 more
openalex   +1 more source

Syntaxin 1A gene polymorphism in multiple sclerosis: a case–control study [PDF]

Mohammed I. Oraby, Rasha H. Soliman, Noha A. Abdel Kader, Esraa M. Abdul Galil, Mohammed Masoud   +4 more
openalex   +1 more source