Results 1 to 10 of about 3,466 (187)

Integrated Genomic Approaches to Elucidate the Genetic Basis of Brugada Syndrome in Taiwanese Patients [PDF]

Bioinformatics and Biology Insights
Brugada syndrome (BrS) is a rare cardiac arrhythmia with a complex and largely unexplained genetic basis. In this study, we analysed genomic data from 214 Taiwanese BrS cases and 1316 controls to uncover susceptibility loci using genome-wide association ...
Chayanika Goswami, Jyh-Ming Jimmy Juang, Tzu-Pin Lu, Jinn-Moon Yang, Amrita Chattopadhyay, Eric Y Chuang   +5 more
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SCN10A gene polymorphism is associated with pain sensitivity and postoperative analgesic effects in patients undergoing gynecological laparoscopy [PDF]

European Journal of Medical Research
Background Postoperative pain intensity is influenced by various factors, including genetic variations. The SCN10A gene encodes the Nav1.8 sodium channel protein, which is crucial for pain signal transmission in peripheral sensory neurons.
Yang Gao, Jing Li, Lin Gan, Meng Cai, Xiaofeng Lei, Jin Yu   +5 more
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Phenotypes in Brugada syndrome with different genotypes triggered by fever or inflammation using gene-edited iPSCs [PDF]

Stem Cell Research & Therapy
Background Fever or inflammation state may enhance the Brugada syndrome (BrS) phenotype in some but not all patients. However, the underlying mechanism in human cardiomyocytes has not yet been clarified. Methods Human induced pluripotent stem cell (hiPSC)
Yingrui Li, Lena Rose, Timo Prädel, Mandy Kleinsorge, Xuehui Fan, Zenghui Meng, Chen Yan, Rui Liu, Xinhao Lei, Binyi Zhao, Guoqiang Yang, Zhenxing Liao, Hendrik Dinkel, Alexandra Viktoria Busley, Rujia Zhong, Feng Zhang, Qiang Xu, Lasse Maywald, Assem Aweimer, Mengying Huang, Alexander Moscu-Gregor, Nazha Hamdani, Luca Schneider, Yeweynwuha Zemedi, Saltanat Zhazykbayeva, Alyssa Hohn, Zhen Yang, Lin Qiao, Andreas Mügge, Lukas Cyganek, Xiaobo Zhou, Ibrahim Akin, Ibrahim El-Battrawy   +32 more
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Identification and validation of key target genes of penning formula for treating rat chronic endometritis model [PDF]

Scientific Reports
This study analyzed transcriptome sequencing data from rat samples, categorized into control (normal), model (chronic endometritis, CE), and test (treated with Penning Formula, PNF) groups, to identify key target genes of PNF in CE treatment and ...
Liu Zhihui, Shi Jiani, Chen Chen, Yuan Yuqiong, Chen Guorun, Zhou Qianru   +5 more
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Characterization of novel arrhythmogenic patterns arising secondary to heterogeneous expression and activation of Nav1.8 [PDF]

Frontiers in Cardiovascular Medicine
BackgroundPrevious studies suggested that SCN10A/Nav1.8 may influence cardiac electrophysiology and the susceptibility to cardiac arrhythmias. Notably, the expression of SCN10A is not uniform, showing variable expression in each cardiac chamber.
Zhong-He Zhang, Zhong-He Zhang, Zhong-He Zhang, Hector Barajas-Martinez, Hector Barajas-Martinez, Hector Barajas-Martinez, Hong-Yi Duan, Hong-Yi Duan, Hong-Yi Duan, Guo-Hua Fan, Hong Jiang, Hong Jiang, Hong Jiang, Charles Antzelevitch, Charles Antzelevitch, Hao Xia, Hao Xia, Hao Xia, Dan Hu, Dan Hu, Dan Hu   +20 more
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Genetic insights into cardiac conduction disorders from genome-wide association studies [PDF]

Human Genomics
Background Substantial data support a heritable basis for cardiac conduction disorders (CCDs), but the genetic determinants and molecular mechanisms of these arrhythmias are poorly understood, therefore, we sought to identify genetic loci associated with
Bingxun Li, Hongxuan Xu, Lin Wu
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Voltage-Gated Sodium Channels: A Therapeutic Target in Ischemic Heart Disease [PDF]

Reviews in Cardiovascular Medicine
Myocardial infarction (MI)-related arrhythmias are an essential risk factor in sudden cardiac death. Aberrant cardiac the cardiac voltage-gated sodium channel (Nav1.5) is important in the development of ventricular arrhythmias after an MI.
Xiao-Lu Zhang, Tian-Peng Wei, Fan Yang, Huan-Huan Liu, Ling-Ling Qian, Ru-Xing Wang   +5 more
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Nav1.8 and Chronic Pain: From Laboratory Animals to Clinical Patients [PDF]

Biomolecules
As a subtype of voltage-gated sodium channel and predominantly expressed in the sensory neurons located in the dorsal root ganglion (DRG), the Nav1.8 channel encoded by the SCN10A gene is found to have different variants in patients suffering chronic ...
Yu-Feng Xie
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Clinical analysis of a family of inappropriate sinus tachycardia with gene variation of SCN10A [PDF]

Xin yixue, 2022
Objective To investigate the association between sinus tachycardia and SCN10A gene. Methods A case of patient with inappropriate sinus tachycardia and SCN10A gene mutation was analyzed. Using the keywords of “sinus tachycardia”and“
Ye Jiayun, Chen Xuezhen, Liao Xiongyu, Qin Lijun
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Targeted phasing of 2–200 kilobase DNA fragments with a short-read sequencer and a single-tube linked-read library method [PDF]

Scientific Reports
In the human genome, heterozygous sites refer to genomic positions with a different allele or nucleotide variant on the maternal and paternal chromosomes.
Veronika Mikhaylova, Madison Rzepka, Tetsuya Kawamura, Yu Xia, Peter L. Chang, Shiguo Zhou, Amber Paasch, Long Pham, Naisarg Modi, Likun Yao, Adrian Perez-Agustin, Sara Pagans, T. Christian Boles, Ming Lei, Yong Wang, Ivan Garcia-Bassets, Zhoutao Chen   +16 more
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