Results 101 to 110 of about 3,466 (187)

The Sunrise of Tertiary Lymphoid Structures in Cancer

Immunological Reviews, Volume 332, Issue 1, July 2025.
ABSTRACT First considered as a negative epiphenomenon in autoimmune and inflammatory diseases, with possible deleterious consequences through the production of pathological autoantibodies and antiself T cells, tertiary lymphoid structures (TLS) have gained major scientific and clinical interest in cancer due to their association with better clinical ...
Juliette Rochefort, Gilles Marodon, Jean‐Luc Teillaud, Marie‐Caroline Dieu‐Nosjean   +3 more
wiley   +1 more source

SCN10A/Nav1.8 modulation of peak and late sodium currents in patients with early onset atrial fibrillation [PDF]

Cardiovascular Research, 2014
To test the hypothesis that vulnerability to atrial fibrillation (AF) is associated with rare coding sequence variation in the SCN10A gene, which encodes the voltage-gated sodium channel isoform NaV1.8 found primarily in peripheral nerves and to identify potentially disease-related mechanisms in high-priority rare variants using in-vitro ...
Eleonora, Savio-Galimberti, Peter, Weeke, Raafia, Muhammad, Marcia, Blair, Sami, Ansari, Laura, Short, Thomas C, Atack, Kaylen, Kor, Carlos G, Vanoye, Morten Salling, Olesen, , LuCamp, Tao, Yang, Alfred L, George, Dan M, Roden, Dawood, Darbar   +14 more
openaire   +2 more sources

Identification of a functional interaction of HMGB1 with Receptor for Advanced Glycation End-products in a model of neuropathic pain [PDF]

, 2014
Recent studies indicate that the release of high mobility group box 1 (HMGB1) following nerve injury may play a central role in the pathogenesis of neuropathic pain.
Allette, Yohance M., Due, Michael R., Feldman, Polina, Khanna, Rajesh, Ripsch, Matthew S., White, Fletcher A., Wilson, Sarah M.   +6 more
core   +1 more source

A Novel Function of NaV Channel β3 Subunit in Endothelial Cell Alignment Through Autophagy Modulation

The FASEB Journal, Volume 39, Issue 11, 15 June 2025.
NaVβ3 expression is increased by laminar shear stress (LSS) through KLF4 induction (1). NaVβ3 is retained within the cell and interacts with mTOR protein and colocalizes partially with LAMP1 and LC3B, lysosome and autophagosome markers, respectively (2). Since SiRNA SCN3B induces the decrease of LC3B expression and cell alignment in response to LSS (3),
Léa Réthoré, Anne‐Laure Guihot, Linda Grimaud, Coralyne Proux, Benjamin Barré, François Guillonneau, Catherine Guette, Alice Boissard, Cécile Henry, Jérôme Cayon, Rodolphe Perrot, Daniel Henrion, Christian Legros, Claire Legendre   +13 more
wiley   +1 more source

Mutations in SCN10A Are Responsible for a Large Fraction of Cases of Brugada Syndrome

Journal of the American College of Cardiology, 2014
BrS is an inherited sudden cardiac death syndrome. Less than 35% of BrS probands have genetically identified pathogenic variants. Recent evidence has implicated SCN10A, a neuronal sodium channel gene encoding Nav1.8, in the electrical function of the heart.The purpose of this study was to test the hypothesis that SCN10A variants contribute to the ...
Hu, Dan, Barajas-Martínez, Hector, Pfeiffer, Ryan, Dezi, Fabio, Pfeiffer, Jenna, Buch, Tapan, Betzenhauser, Matthew J, Belardinelli, Luiz, Kahlig, Kristopher M, Rajamani, Sridharan, DeAntonio, Harry J, Myerburg, Robert J, Ito, Hiroyuki, Deshmukh, Pramod, Marieb, Mark, Nam, Gi-Byoung, Bhatia, Atul, Hasdemir, Can, Haïssaguerre, Michel, Veltmann, Christian, Schimpf, Rainer, Borggrefe, Martin, Viskin, Sami, Antzelevitch, Charles   +23 more
openaire   +4 more sources

The role of genetic testing in unexplained sudden death. [PDF]

, 2015
Most sudden deaths are because of a cardiac etiology and are termed sudden cardiac death (SCD). In younger individuals coronary artery disease is less prevalent and cardiac genetic disorders are more common.
Behr, ER, Miles, CJ
core   +1 more source

Sudden unexpected infant death, sudden unexplained death in childhood, and sudden unexpected death in epilepsy

Developmental Medicine &Child Neurology, Volume 67, Issue 6, Page 734-739, June 2025.
Abstract Sudden deaths in infants and children represent a profound and tragic event that continues to challenge researchers despite extensive investigation over several decades. The predominant phenotype, sudden infant death syndrome (SIDS), has evolved into the broader category of sudden unexpected infant death (SUID).
Suvasini Sharma, Robyn Whitney, Sayoni Roy Chowdhury, Rajesh Ramachandrannair   +3 more
wiley   +1 more source

SCN10A-knock-out improves survival and proarrhythmia in a transgenic heart failure mouse model

European Heart Journal, 2020
Abstract Background In heart failure (HF) both Ca2+/Calmodulin-dependent protein-kinase II (CaMKII) and late sodium current (INaL) are known to contribute to arrhythmogenesis as they contribute to action-potential (AP) prolongation and the occurrence of early- (EADs) and delayed afterdepolarizations ...
P.R.F Bengel, C Krekeler, S Ahmad, N Hartmann, P Tirilomis, W Maurer, K Toischer, L.S Maier, G Hasenfuss, K Streckfuss-Boemeke, N Dybkova, S Sossalla   +11 more
openaire   +1 more source

Hypoxia Produces Pro-arrhythmic Late Sodium Current in Cardiac Myocytes by SUMOylation of NaV1.5 Channels. [PDF]

, 2020
Acute cardiac hypoxia produces life-threatening elevations in late sodium current (ILATE) in the human heart. Here, we show the underlying mechanism: hypoxia induces rapid SUMOylation of NaV1.5 channels so they reopen when normally inactive, late in the ...
Dai, Hui, Goldstein, Steve AN, Plant, Leigh D, Romero, Jesus, Xiong, Dazhi   +4 more
core  

Heritabilities, proportions of heritabilities explained by GWAS findings, and implications of cross-phenotype effects on PR interval [PDF]

, 2015
Electrocardiogram (ECG) measurements are a powerful tool for evaluating cardiac function and are widely used for the diagnosis and prediction of a variety of conditions, including myocardial infarction, cardiac arrhythmias, and sudden cardiac death ...
Amin, N. (Najaf), Dehghan, A. (Abbas), Duijn, C.M. (Cornelia) van, Isaacs, A.J. (Aaron), Kors, J.A. (Jan), Oostra, B.A. (Ben), Silva Aldana, C.T. (Claudia), Willemsen, R. (Rob), Witteman, J.C.M. (Jacqueline)   +8 more
core   +1 more source