Results 111 to 120 of about 3,466 (187)

Screening of candidate analgesics using a patient‐derived human iPSC model of nociception identifies putative compounds for therapeutic treatment

Clinical and Translational Medicine, Volume 15, Issue 5, May 2025.
In this study, Thornton and colleagues utilised an induced pluripotent stem cell (iPSC)‐based model of inherited erythromelalgia (IEM) to screen a library of 295 small molecules in search of potential pain‐modulating compounds. Their screening identified four compounds that significantly reduced spontaneous firing in iPSC‐derived nociceptor‐like cells,
Jack R. Thornton, Alberto Capurro, Sally Harwood, Thomas C Henderson, Adrienne Unsworth, Franziska Görtler, Sushma Nagaraja‐Grellscheid, Vsevolod Telezhkin, Majlinda Lako, Evelyne Sernagor, Lyle Armstrong   +10 more
wiley   +1 more source

Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group [PDF]

, 2018
Sulfonylureas, a commonly used class of medication used to treat type 2 diabetes, have been associated with an increased risk of cardiovascular disease.
Avery, C.L., Bis, J.C., Brody, J.A., Broer, L., Busch, E.L., Chen, Y.-DI., Cummings, S.R., Cupples, L.A., de Mutsert, R., Duan, Q., Eicher, J.D., Evans, D.S., Floyd, J.S., Gogarten, S.M., Gudnason, V., Harris, T.B., Heckbert, S.R., Johnson, A.D., Jukema, J.W., Kaplan, R.C., Kerr, K.F., Kors, J.A., Lange, L.A., Launer, L.J., Laurie, C.C., Li, J., Li, X., Li, Y., Li-Gao, R., Lin, H.J., Liu, Y., Mook-Kanamori, D.O., Méndez-Giráldez, R., Napier, M.D., Noordam, R., Psaty, B.M., Reiner, A.P., Rice, K.M., Roach, J., Rosendaal, F.R., Rotter, J.I., Sattar, N., Seyerle, A.A., Sitlani, C.M., Slagboom, P.E., Smith, A.V., Soliman, E.Z., Sotoodehnia, N., Stewart, J.D., Stott, D.J., Stricker, B.H., Stürmer, T., Taylor, K.D., Trompet, S., Uitterlinden, A.G., Whitsel, E.A., Wiggins, K.L., Wilhelmsen, K.C., Wilson, J.G.   +58 more
core   +4 more sources

Molecular pathophysiology and pharmacology of the voltage-sensing module of neuronal ion channels [PDF]

, 2015
Voltage-gated ion channels (VGICs) are membrane proteins that switch from a closed to open state in response to changes in membrane potential, thus enabling ion fluxes across the cell membranes.
Alessandro eMedoro, Francesco eMiceli, Laura eManocchio, Maria Virginia eSoldovieri, Maurizio eTaglialatela, Maurizio eTaglialatela, Michela eDe Maria, Paolo eAmbrosino   +7 more
core   +2 more sources

Painful stimulation increases functional connectivity between supplementary motor area and thalamus in patients with small fibre neuropathy

European Journal of Pain, Volume 29, Issue 2, February 2025.
Abstract Background The lead symptom of small fibre neuropathy (SFN) is neuropathic pain. Recent functional magnetic resonance imaging (fMRI) studies have indicated central changes in SFN patients of different etiologies. However, less is known about brain functional connectivity during acute pain processing in idiopathic SFN. Methods We conducted fMRI
Sebastian Scheliga, Maike F. Dohrn, Thilo Kellermann, Angelika Lampert, Roman Rolke, Barbara Namer, Greta Z. Peschke, Nortje van den Braak, Annette Lischka, Marc Spehr, Han‐Gue Jo, Ute Habel   +11 more
wiley   +1 more source

Nociceptive Sensory Neurons Drive Interleukin-23 Mediated Psoriasiform Skin Inflammation [PDF]

, 2015
The skin has a dual function as a barrier and a sensory interface between the body and the environment. To protect against invading pathogens, the skin harbors specialized immune cells, including dermal dendritic cells (DDCs) and interleukin (IL)-17 ...
Alvarez, David, Naval, Elena, Ordovas-Montanes, Jose, Perro, Mario, Riol-Blanco, Lorena, Thiriot, Aude, von Andrian, Ulrich H., Wood, John N.   +7 more
core   +1 more source

Long-range regulatory interactions at the 4q25 atrial fibrillation risk locus involve PITX2c and ENPEP [PDF]

, 2016
This is an Open Access article distributed under the terms of the Creative Commons Attribution License.-- et al.[Background]: Recent genome-wide association studies have uncovered genomic loci that underlie an increased risk for atrial fibrillation, the ...
Alonso, M. Eva, Fernández-Miñán, Ana, Gómez-Skarmeta, José Luis, Manzanares, Miguel   +3 more
core   +1 more source

Absence of a Primary Role for SCN10A Mutations in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

Journal of Cardiovascular Translational Research, 2016
Prior reports have identified associations between SCN10A and cardiac disorders, such as atrial fibrillation and Brugada syndrome. We evaluated SCN10A in 151 probands with ARVD/C. In this cohort, 10 putatively pathogenic SCN10A variants were identified, including a novel frameshift insertion.
Te Riele, Anneline S J M, James, Cynthia A, Murray, Brittney, Tichnell, Crystal, Amat-Alarcon, Nuria, Burks, Kathleen, Tandri, Harikrishna, Calkins, Hugh, Polydefkis, Michael, Judge, Daniel P   +9 more
openaire   +4 more sources

Una mutación con cambio de sentido c.1661T>C en el gen SCN10A que genera ganancia de función del canal Nav1.8 y síndrome de QT largo congénito

Revista Interamericana de Cardiología
Introducción: Las mutaciones con ganancia de función del canal Nav1.8, codificado por el gen SCN10A, se asocian a neuropatía periférica dolorosa. Evidencias recientes indican que las mutaciones de SCN10A pueden asociarse a canalopatías cardíacas como el ...
Hyun S. Yoo, Pablo A. Fernández, Daniel E. Etcheverry, Hugo A. Garro, Florencia Muschietti, Paola Settepassi, Rocío Villa-Fernández, Analia G. Paolucci, Mario B. Principato, Justo Carbajales   +9 more
doaj  

The Diversity of REcent and Ancient huMan (DREAM): a new microarray for genetic anthropology and genealogy, forensics, and personalized medicine [PDF]

, 2017
The human population displays wide variety in demographic history, ancestry, content of DNA derived from hominins or ancient populations, adaptation, traits, copy number variation (CNVs), drug response, and more. These polymorphisms are of broad interest
Ainan I J Anderson, Dimitrios Arnellos, Eran Elhaik, Gregory Vilshansky, Gunes Ercal, illumina, illumina, illumina, illumina, Leeban Yusuf, Mehdi Pirooznia, Michael L Baird, Teresa Webster, Thermo Fisher Scientific, Thermo Fisher Scientific, Thermo Fisher Scientific, Umberto Esposito, Yontao Lu   +17 more
core   +1 more source

A novel Nav1.8-FLPo driver mouse for intersectional genetics to uncover the functional significance of primary sensory neuron diversity

iScience
Summary: The recent development of single-cell and single-nucleus RNA sequencing has highlighted the extraordinary diversity of dorsal root ganglia neurons.
Pascale Malapert, Guillaume Robert, Elena Brunet, Jean Chemin, Emmanuel Bourinet, Aziz Moqrich   +5 more
doaj   +1 more source