Results 181 to 187 of about 3,466 (187)

Genetic variation in SCN10A influences cardiac conduction

Nature Genetics, 2010
To identify genetic factors influencing cardiac conduction, we carried out a genome-wide association study of electrocardiographic time intervals in 6,543 Indian Asians. We identified association of a nonsynonymous SNP, rs6795970, in SCN10A (P = 2.8 x 10(-15)) with PR interval, a marker of cardiac atrioventricular conduction.
Chambers, John C., Zhao, Jing, Terracciano, Cesare M. N., Bezzina, Connie R., Zhang, Weihua, Kaba, Riyaz, Navaratnarajah, Manoraj, Lotlikar, Amol, Sehmi, Joban S., Kooner, Manraj K., Deng, Guohong, Siedlecka, Urszula, Parasramka, Saurabh, El-Hamamsy, Ismail, Wass, Mark N., Dekker, Lukas R. C., de Jong, Jonas S. S. G., Sternberg, Michael J. E., McKenna, William, Severs, Nicholas J., de Silva, Ranil, Wilde, Arthur A. M., Anand, Praveen, Yacoub, Magdi, Scott, James, Elliott, Paul, Wood, John N., Kooner, Jaspal S.   +27 more
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Genetic polymorphisms of SCN10A are associated with functional dyspepsia in Japanese subjects

Journal of Gastroenterology, 2012
Visceral sensory impulses are transmitted via C-fibers from the gastrointestinal tract to the central nervous system. The tetrodotoxinresistant (TTX-r) sodium channel, Na(V) 1.8/SNS (sensory-neuron specific), encoded by SCN10A, has been identified on C-fibers.
Tomiyasu, Arisawa, Tomomitsu, Tahara, Hisakazu, Shiroeda, Takahiro, Minato, Yasuhiro, Matsue, Takashi, Saito, Tomoki, Fukuyama, Toshimi, Otsuka, Atsushi, Fukumura, Masakatsu, Nakamura, Tomoyuki, Shibata   +10 more
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การวิเคราะห์การกลายพันธุ์ของยีน SCN10A ในผู้ป่วยโรคนิ่วไตในภาคตะวันออกเฉียงเหนือของไทย ด้วยวิธี high resolution melting (Analysis of SCN10A Gene Mutation in Northeastern Thai Patients with Nephrolithiasis by High Resolution Melting Method)

2013
S1 (Special Issue 1), S.1, Thai Journal of ...
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A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/ SCN10A

Pain, 1998
Neuropathic pain may be produced, at least in part, by the increased activity of primary afferent neurons. Studies have suggested that an accumulation of voltage-gated sodium channels at the site of peripheral nerve injury is a primary precursory event for subsequent afferent hyperexcitability.
Douglas K, Rabert, Bruce D, Koch, Mariola, Ilnicka, Rena A, Obernolte, Susan L, Naylor, Ronald C, Herman, Richard M, Eglen, John C, Hunter, Lakshmi, Sangameswaran   +8 more
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Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouse

Mammalian Genome, 1996
C A, Kozak, L, Sangameswaran
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In Silico Investigation of the Functional Impact of SCN10A Mutations in Human Atrial Cells

2018
In normal conditions, action potential (AP) in cardiac myocytes is initiated by peak sodium current 𝐼"#$, which become inactivated during depolarization, leaving a less pronounce current known as late sodium current (𝐼"#%), which has a relatively smaller amplitude (~0.5%) compared to the 𝐼"#$. A recent study has identified three
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SCN10A: Structure, Function, and Therapeutic Implications

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