Results 31 to 40 of about 3,466 (187)

Nav-igating through a complex landscape: SCN10A and cardiac conduction [PDF]

Journal of Clinical Investigation, 2014
Genome-wide association studies (GWAS) have implicated SCN10A, which encodes a nociceptor-associated voltage-gated sodium channel subunit, as a modulator of cardiac conduction; however, this role has traditionally been ascribed to SCN5A, which is highly expressed in cardiac muscle. SCN10A is believed to affect cardiac conduction either directly through
David S, Park, Glenn I, Fishman
openaire   +2 more sources

Expression and Physiology of Voltage-Gated Sodium Channels in Developing Human Inner Ear

Frontiers in Neuroscience, 2021
Sodium channel expression in inner ear afferents is essential for the transmission of vestibular and auditory information to the central nervous system.
Rikki K. Quinn, Rikki K. Quinn, Hannah R. Drury, Hannah R. Drury, Ethan T. Cresswell, Ethan T. Cresswell, Melissa A. Tadros, Melissa A. Tadros, Bryony A. Nayagam, Robert J. Callister, Robert J. Callister, Alan M. Brichta, Alan M. Brichta, Rebecca Lim, Rebecca Lim   +14 more
doaj   +1 more source

Taxane-induced sensory peripheral neuropathy is associated with an SCN9A single nucleotide polymorphism in Japanese patients

BMC Cancer, 2020
Background Sodium channels located in the dorsal root ganglion, particularly Nav1.7 and Nav1.8, encoded by SCN9A and SCN10A, respectively, act as molecular gatekeepers for pain detection.
Yuko Tanabe, Seiji Shiraishi, Kenji Hashimoto, Kazutaka Ikeda, Daisuke Nishizawa, Junko Hasegawa, Akihiko Shimomura, Yukinori Ozaki, Nobuko Tamura, Mayu Yunokawa, Kan Yonemori, Toshimi Takano, Hidetaka Kawabata, Kenji Tamura, Yasuhiro Fujiwara, Chikako Shimizu   +15 more
doaj   +1 more source

Lipopolysaccharide Modifies Sodium Current Kinetics through ROS and PKC Signalling in Induced Pluripotent Stem-Derived Cardiomyocytes from Brugada Syndrome Patient

Journal of Cardiovascular Development and Disease, 2022
Studies have suggested a connection between inflammation and arrhythmogenesis of Brugada syndrome (BrS). However, experimental studies regarding the roles of inflammation in the arrhythmogenesis of BrS and its underlying mechanism are still lacking. This
Zhenxing Liao, Yingrui Li, Xuehui Fan, Zhen Yang, Ibrahim El-Battrawy, Xiaobo Zhou, Ibrahim Akin   +6 more
doaj   +1 more source

The Role of Voltage-Gated Sodium Channel 1.8 in the Effect of Atropine on Heart Rate: Evidence From a Retrospective Clinical Study and Mouse Model

Frontiers in Pharmacology, 2020
Atropine is commonly used to counter the effects of the parasympathetic neurotransmitter acetylcholine on heart rate in clinical practice, such as in the perioperative period; however, individual differences in the response to atropine are huge.
Baowen Liu, Baowen Liu, Ningbo Li, Jin Zhang, Yi Liu, Mi Zhang, Yishun Hong, Wenyao Wu, Xianwei Zhang, Guangyou Duan   +9 more
doaj   +1 more source

Contrasting Nav1.8 Activity in Scn10a−/− Ventricular Myocytes and the Intact Heart

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundGenome‐wide association studies have implicated variants in SCN10A, which encodes Nav1.8, as modulators of cardiac conduction. Follow‐up work has indicated the SCN10A sequence includes an intronic enhancer for SCN5A.
Dina Myers Stroud, Tao Yang, Kevin Bersell, Dymtro O. Kryshtal, Satomi Nagao, Christian Shaffer, Laura Short, Lynn Hall, Thomas C. Atack, Wei Zhang, Bjorn C. Knollmann, Franz Baudenbacher, Dan M. Roden   +12 more
doaj   +1 more source

Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial [PDF]

, 2016
Carboplatin/taxane combination is first-line therapy for ovarian cancer. However, patients can encounter treatment delays, impaired quality of life, even death because of chemotherapy-induced gastrointestinal (GI) toxicity.
Brown, R., Glass, S., He, Y.J., Hoskins, J.M., McLeod, H.L., Motsinger-Reif, A., Paul, J., Winham, S.J.   +7 more
core   +1 more source

A Computational Modeling Investigation into SCN10A Linked Brugada Syndrome [PDF]

Biophysical Journal, 2016
A functional role for the sodium channel NaV1.8 in the heart is unclear. Mutations and polymorphisms in SCN10A, the gene encoding NaV1.8, have recently been linked to Brugada Syndrome, an inherited cardiac disease that causes sudden death. The Brugada Syndrome is detected on an ECG by the hallmark appearance of coved type ST-segment elevation (J-wave ...
Vincent, Marcus, Yang, Pei-Chi, Clancy, Colleen E.   +2 more
openaire   +1 more source

Pain behavior in SCN9A (Nav1.7) and SCN10A (Nav1.8) mutant rodent models

Neuroscience Letters, 2021
The two voltage gated sodium channels Nav1.7 and Nav1.8 are expressed in the peripheral nervous system and involved in various pain conditions including inflammatory and neuropathic pain. Rodent models bearing deletions or mutations of the corresponding genes, Scn9a and Scn10a, were created in order to understand the role of these channels in the ...
Xue, Yaping, Chidiac, Celeste, Herault, Yann, Gaveriaux-Ruff, Claire   +3 more
openaire   +4 more sources

A NOVEL GENETIC MARKER FOR INHERITED DISORDER OF THE HEART CONDUCTION SYSTEM

Российский кардиологический журнал, 2015
Aim. To study relation of mononucleotide polymorphism G>A of the gene SCN10A and development of inherited pathology of the heart conduction system.Material and methods. Totally, 260 persons investigated with primary disorders of cardiac conduction (71
S. Yu. Nikulina, A. A. Chernova, S. S. Tretyakova   +2 more
doaj   +1 more source