Results 61 to 70 of about 3,466 (187)

Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram [PDF]

, 2016
The ST-segment and adjacent T-wave (ST-T wave) amplitudes of the electrocardiogram are quantitative characteristics of cardiac repolarization. Repolarization abnormalities have been linked to ventricular arrhythmias and sudden cardiac death. We performed
Alizadeh, B.Z. (Behrooz), Alonso, A. (Alvaro), Arking, D.E. (Dan), Bakker, P.I.W. (Paul) de, Barnett, P. (Phil), Berg, M.E. (Marten) van den, Bis, J.C. (Joshua), Boer, R.A. (Rudolf) de, Boezen, H.M. (Marike), Boyer, L.A. (Laurie A.), Bruinenberg, M. (M.), Duijn, C.M. (Cornelia) van, Eijgelsheim, M. (Mark), Festen, N. (Noortje), Franke, L. (Lude), Gilst, W.H. (Wiek) van, Harst, P. (Pim) van der, Hillege, H.L. (Hans), Hirschhorn, J.N. (Joel), Isaacs, A.J. (Aaron), Klauw, M. (Melanie van der), Kors, J.A. (Jan), Kähönen, M. (Mika), Leach, I.M. (Irene Mateo), Lehtimäki, T. (Terho), Lyytikäinen, L.-P. (Leo-Pekka), Navis, G. (Gerjan), Ormel, H. (Hans), Pers, T.H. (Tune), Postma, D.S. (Dirkje), Raitakari, O.T. (Olli T.), Rosmalen, J.G.M. (Judith), Silva Aldana, C.T. (Claudia), Slaets, J.P.J. (Joris), Snieder, H. (Harold), Soliman, E.Z. (Elsayed Z.), Sotoodehnia, N. (Nona), Stolk, R.P., Van Veldhuisen, D.J. (Dirk J.), Verweij, N. (Niek), Wang, X. (Xinchen), Wijmenga, C. (Cisca), Wolffenbuttel, B.H.R. (Bruce H. R.)   +42 more
core   +1 more source

Blocking Scn10a Channels in Heart Reduces Late Sodium Current and Is Antiarrhythmic [PDF]

Circulation Research, 2012
Rationale: Although the sodium channel locus SCN10A has been implicated by genome-wide association studies as a modulator of cardiac electrophysiology, the role of its gene product Nav1.8 as a modulator
Tao, Yang, Thomas C, Atack, Dina Myers, Stroud, Wei, Zhang, Lynn, Hall, Dan M, Roden   +5 more
openaire   +2 more sources

Single nucleotide polymorphisms associated with postoperative inadequate analgesia after single-port VATS in Chinese population

BMC Anesthesiology, 2020
Background Postoperative inadequate analgesia following video-assisted thoracoscopic surgery (VATS) is a common and significant clinical problem. While genetic polymorphisms may play role in the variability of postoperative analgesia effect, few studies ...
Xiufang Xing, Yongyu Bai, Kai Sun, Min Yan   +3 more
doaj   +1 more source

CaMKII-dependent regulation of cardiac Na(+) homeostasis. [PDF]

, 2014
Na(+) homeostasis is a key regulator of cardiac excitation and contraction. The cardiac voltage-gated Na(+) channel, NaV1.5, critically controls cell excitability, and altered channel gating has been implicated in both inherited and acquired arrhythmias.
Grandi, Eleonora, Herren, Anthony W
core   +2 more sources

KCNN2 polymorphisms and cardiac tachyarrhythmias [PDF]

, 2016
Potassium calcium-activated channel subfamily N member 2 (KCNN2) encodes an integral membrane protein that forms small-conductance calcium-activated potassium (SK) channels.
Chen, Chi-Ling, Chen, Pei-Lung, Chen, Peng-Sheng, Chia-Ti, Tsai, Chiang, Fu-Tien, Chiu, Fu-Chun, Ho, Li-Ting, Juang, Jyh-Ming, Lai, Ling-Ping, Lin, Jiunn-Lee, Lin, Lian-Yu, Wu, Cho-Kai, Yang, Wei-Shiung, Yu, Chih-Chieh   +13 more
core   +1 more source

Generation of two induced pluripotent stem cell lines from skin fibroblasts of sisters carrying a c.1094C>A variation in the SCN10A gene potentially associated with small fiber neuropathy

Stem Cell Research, 2019
Induced pluripotent stem cells (iPSC) were derived from human dermal fibroblasts (HDF) of two siblings with small fiber neuropathy (SFN) potentially based on the same variation in SCN10A but exhibiting diverse disease phenotypes.
Thomas Klein, Katharina Klug, Lisa Henkel, Chee Keong Kwok, Frank Edenhofer, Eva Klopocki, Ingo Kurth, Nurcan Üçeyler   +7 more
doaj   +1 more source

Causal associations between cardiorespiratory fitness and type 2 diabetes

Nature Communications, 2023
Higher cardiorespiratory fitness is associated with lower risk of type 2 diabetes. However, the causality of this relationship and the biological mechanisms that underlie it are unclear.
Lina Cai, Tomas Gonzales, Eleanor Wheeler, Nicola D. Kerrison, Felix R. Day, Claudia Langenberg, John R. B. Perry, Soren Brage, Nicholas J. Wareham   +8 more
doaj   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Human Sensory Neuron-like Cells and Glycated Collagen Matrix as a Model for the Screening of Analgesic Compounds

Cells, 2022
Increased collagen-derived advanced glycation end-products (AGEs) are consistently related to painful diseases, including osteoarthritis, diabetic neuropathy, and neurodegenerative disorders. We have recently developed a model combining a two-dimensional
Michelle Cristiane Bufalo, Maíra Estanislau Soares de Almeida, José Ricardo Jensen, Carlos DeOcesano-Pereira, Flavio Lichtenstein, Gisele Picolo, Ana Marisa Chudzinski-Tavassi, Sandra Coccuzzo Sampaio, Yara Cury, Vanessa Olzon Zambelli   +9 more
doaj   +1 more source

Repurposing the KCa3.1 inhibitor senicapoc for Alzheimer's disease. [PDF]

, 2019
ObjectiveMicroglia play a pivotal role in the initiation and progression of Alzheimer's disease (AD). We here tested the therapeutic hypothesis that the Ca2+-activated potassium channel KCa3.1 constitutes a potential target for treating AD by reducing ...
Bushong, Trevor, Chavez, Monique, Jin, Lee-Way, Lucente, Jacopo Di, Maezawa, Izumi, Nguyen, Hai M, Singh, Latika, Singh, Vikrant, Wulff, Heike   +8 more
core   +2 more sources