Results 71 to 80 of about 3,466 (187)
Properties of the Domain-II Voltage Sensor Determining the Function of Nav1.8 (SCN10A) Channels [PDF]
, 2010 Stable isotope record from snow pit ...
Arnaud, Laurent +12 more
core +1 more source
Advanced Science, Volume 13, Issue 6, 30 January 2026.This study describes derivation of two distinct mechanosensory subpopulations from human pluripotent stem cells using a transcription factor mediated approach. Of significance, functional interrogation of induced mechanosensory subtypes reveal their unique responses to mechanical stimulation in the absence of end‐organs.
Amy J. Hulme +12 more
wiley +1 more source
Exon 11 skipping of SCN10A coding for voltage-gated sodium channels in dorsal root ganglia [PDF]
Channels, 2014 The voltage-gated sodium channel Na(V)1.8 (encoded by SCN10A) is predominantly expressed in dorsal root ganglia(DRG) and plays a critical role in pain perception. We analyzed SCN10A transcripts isolated from human DRGs using deep sequencing and found a novel splice variant lacking exon 11, which codes for 98 amino acids of the domain I/II linker ...
Schirmeyer, Jana +5 more
openaire +3 more sources
Allele-specific NKX2-5 binding underlies multiple genetic associations with human electrocardiographic traits. [PDF]
, 2019 The cardiac transcription factor (TF) gene NKX2-5 has been associated with electrocardiographic (EKG) traits through genome-wide association studies (GWASs), but the extent to which differential binding of NKX2-5 at common regulatory variants contributes
Benaglio, Paola +17 more
core
Modeling human epilepsy by TALEN targeting of mouse sodium channel Scn8a [PDF]
, 2013 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106152/1/dvg22731 ...
Jones, Julie M., Meisler, Miriam H.
core +1 more source
Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo [PDF]
, 2009 Background Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter which mainly mediates its effects on neurons via ionotropic (GABAA) and metabotropic (GABAB) receptors.
Bernhard Bettler +9 more
core +3 more sources
Sensory Neuroscience, Volume 1, Issue 3, December 2025.ABSTRACT Sensory neuron disorders, such as peripheral neuropathies and trigeminal neuralgia, cause chronic pain and sensory dysfunction; however, regenerative treatments are limited. Human pluripotent stem cells (hPSCs) provide a powerful platform to model these diseases by generating functional sensory neuron subtypes, including nociceptors and ...
Pushpanathan Muthuirulan +3 more
wiley +1 more source
Functional characterization of SCN10A variants in several cases of sudden unexplained death
Forensic Science International, 2019 Multiple genome-wide association studies (GWAS) and targeted gene sequencing have identified common variants in SCN10A in cases of PR and QRS duration abnormalities, atrial fibrillation and Brugada syndrome. The New York City Office of Chief Medical Examiner has now also identified five SCN10A variants of uncertain significance in six separate cases ...
Ivan Gando +5 more
openaire +3 more sources
Genome-Wide Mapping of in Vivo Protein-DNA Interactions [PDF]
, 2007 In vivo protein-DNA interactions connect each transcription factor with its direct targets to form a gene network scaffold. To map these protein-DNA interactions comprehensively across entire mammalian genomes, we developed a large-scale chromatin ...
Johnson, David S. +3 more
core +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Ion channels
British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +86 more
wiley +1 more source