Results 101 to 110 of about 4,664 (202)

Vector‐mediated release of GABA attenuates pain‐related behaviors and reduces Na V 1.7 in DRG neurons [PDF]

open access: yes, 2011
Pain is a common and debilitating accompaniment of neuropathy that occurs as a complication of diabetes. In the current study, we examined the effect of continuous release of gamma amino butyric acid (GABA), achieved by gene transfer of glutamic acid ...
Baron   +55 more
core   +1 more source

Molecular Mechanisms of Chronic Pain and Therapeutic Interventions

open access: yesMedComm, Volume 6, Issue 8, August 2025.
We offer a comprehensive overview of the distinctive molecular mechanisms underlying nociceptive, neuropathic, and nociplastic pain, including the immune responses, ion channels, monoaminergic imbalance, and neuroinflammation. Subsequently, we summarized the status quo of nociceptive, neuropathic, and nociplastic pain managementmanipulation.
Zhen Li   +8 more
wiley   +1 more source

Comprehensive Exonic Sequencing of Known Ataxia Genes in Episodic Ataxia

open access: yesBiomedicines, 2020
Episodic Ataxias (EAs) are a small group (EA1–EA8) of complex neurological conditions that manifest as incidents of poor balance and coordination. Diagnostic testing cannot always find causative variants for the phenotype, however, and this along with ...
Neven Maksemous   +4 more
doaj   +1 more source

Genetic diagnosis of severe myoclonic epilepsy of infancy (Dravet syndrome) with SCN1A mutations in the Hong Kong Chinese patients [PDF]

open access: yes, 2011
Epilepsy is a clinically and genetically heterogeneous group of disorders. The advent of molecular genetics brings unprecedented advancement in diagnostic molecular pathology and reduces over-reliance on traditional clinical classification.
Chan, AYW   +7 more
core  

Pathway Analyses of Inherited Neuropathies Identify Putative Common Mechanisms of Axon Degeneration

open access: yesAnnals of Clinical and Translational Neurology, Volume 12, Issue 7, Page 1454-1464, July 2025.
ABSTRACT Objective Inherited neuropathies (IN) are associated with over 100 different genetic mutations presenting with a variety of phenotypes. This complexity suggests multiple pathways may converge onto a limited number of downstream pathways to effect axonal injury.
Christopher R. Cashman   +2 more
wiley   +1 more source

Dendritikus sejt altípusok együttműködése fiziológiás és kóros állapotban = The interplay of dendritic cell subtypes in health and disease [PDF]

open access: yes, 2011
A dendritikus sejtek (DC) az immunfolyamatok fontos irányítói, melyek alapvető szerepet játszanak a központi és perifériás tolerancia és a gyulladásos folyamatok kiváltásában, fenntartásában és szabályozásában.
Benkő, Szilvia   +9 more
core  

Association of Polymorphisms in Pharmacogenetic Candidate Genes with Propofol Susceptibility

open access: yesScientific Reports, 2017
Significant individual susceptibility to intravenous anesthetic propofol exists. The etiology of individual variability in the response to propofol may be influenced by genetic polymorphisms in metabolic and functional pathways.
Qi Zhong   +4 more
doaj   +1 more source

Behavioral and omics analyses study on potential involvement of dipeptide balenine through supplementation in diet of senescence-accelerated mouse prone 8 [PDF]

open access: yes, 2016
This study investigates effects of dipeptide balenine, as a major component of whale meat extract (hereafter, WME), supplementation on senescence-accelerated mouse prone 8 (SAMP8), an Alzheimer\u27s disease (AD) model at level of learning and memory ...
Hirako Satoshi   +12 more
core   +1 more source

Molecular pathophysiology and pharmacology of the voltage-sensing module of neuronal ion channels [PDF]

open access: yes, 2015
Voltage-gated ion channels (VGICs) are membrane proteins that switch from a closed to open state in response to changes in membrane potential, thus enabling ion fluxes across the cell membranes.
Alessandro eMedoro   +7 more
core   +2 more sources

A comprehensive assessment of benign genetic variability for neurodegenerative disorders [PDF]

open access: yes, 2018
Over the last few years, as more and more sequencing studies have been performed, it has become apparent that the identification of pathogenic mutations is, more often than not, a complex issue.
Andrew Singleton   +19 more
core   +2 more sources

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