Results 41 to 50 of about 125,455 (359)

PIEZO1‐GPX4 Axis Mediates Mechanical Stress‐Induced Vertebral Growth Plate Dysplasia via Ferroptosis Activation

Advanced Science, EarlyView.
Mechanical stress activates PIEZO1 in vertebral growth plate chondrocytes, triggering ferroptosis through direct binding and inhibition of GPX4. This axis promotes lipid peroxidation and pathological ossification, accelerating spinal deformities. Clinical and genetic evidence (Piezo1‐cKO) confirms its role in scoliosis progression.
Fei Chen, Fushuai Peng, Shuqing Chen, Yukun Du, Jianyi Li, Yuanyuan Fan, Zichen Cui, Guanghui Gu, Han Zhang, Zhensong Jiang, Guodong Wang, Xingzhi Jing, Jun Dong, Tao Li, Yongming Xi   +14 more
wiley   +1 more source

Upregulation of microRNA-96-5p is associated with adolescent idiopathic scoliosis and low bone mass phenotype

Scientific Reports, 2022
Bone densitometry revealed low bone mass in patients with adolescent idiopathic scoliosis (AIS) and its prognostic potential to predict curve progression.
Huanxiong Chen, Kenneth Guangpu Yang, Jiajun Zhang, Ka-yee Cheuk, Evguenia Nepotchatykh, Yujia Wang, Alec Lik-hang Hung, Tsz-ping Lam, Alain Moreau, Wayne Yuk-wai Lee   +9 more
doaj   +1 more source

Scoliosis in myelomeningocele

Acta Orthopaedica, 1988
Prevalence, type, and magnitude of scoliosis were studied in 163 patients with myelomeningocele. A scoliosis was diagnosed in 143 of them, congenital in 15 percent of the cases and developmental in the remaining patients. The severity of scoliosis increased with age and was more severe the higher the level of the neurologic deficit.
L. Samuelsson, Ole Eklöf
openaire   +3 more sources

Epidemiology of adolescent idiopathic scoliosis

Journal of Children's Orthopaedics, 2013
Adolescent idiopathic scoliosis is a common disease with an overall prevalence of 0.47–5.2 % in the current literature. The female to male ratio ranges from 1.5:1 to 3:1 and increases substantially with increasing age.
M. Konieczny, H. Senyurt, R. Krauspe
semanticscholar   +1 more source

Human iPSCs Derived MSCs‐Secreted Exosomes Modulate Senescent Nucleus Pulposus Cells Induced Macrophage Polarization via Metabolic Reprogramming to Mitigate Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Senescent nucleus pulposus cells drive inflammatory M1 macrophage polarization, exacerbating intervertebral disc degeneration (IDD). Conversely, M1 macrophages accelerate NP cell senescence, creating a vicious cycle. iPSCs‐derived mesenchymal stem cell (iMSCs) exosomes break this loop by delivering miR‐100‐5p to suppress mTORC1/glycolysis in ...
Qian Xiang, Jiawen Zhan, Shuo Tian, Yongzhao Zhao, Zhenquan Wu, Jialiang Lin, Longting Chen, Longjie Wang, Shuai Jiang, Zhuoran Sun, Weishi Li   +10 more
wiley   +1 more source

Truncating Variants in RREB1 Cause a Novel RASopathy Syndrome of Congenital Heart Disease, Genitourinary Malformations, and Developmental Delay

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The interstitial 6p microdeletion syndrome is characterized by dysmorphic facies and structural heart, kidney, brain, and musculoskeletal differences. RREB1 haploinsufficiency and consequent abnormal RAS‐MAPK pathway signaling have been proposed as a driver of the disease phenotype; however, apart from a single case report, the phenotype of ...
Alanna Strong, Caoimhe McKenna, Karen Stals, Antonio Vitobello, Mathilde Renaud, Claudine Rieubland, Michel Guipponi, Christophe Philippe, Paul Vrana, Alisa Gaskell, A. Micheil Innes, Alyssa L. Rippert, Rebecca Ahrens‐Nicklas, Elizabeth Bhoj, Kiersten Keller, Bimal P. Chaudhari, Brandon S. Stone   +16 more
wiley   +1 more source

Polyarticular Septic Arthritis in an Immunocompetent Adult: A Case Report and Review of the Literature

Case Reports in Orthopedics, 2015
Septic arthritis is a clinical emergency requiring prompt diagnosis and treatment to avoid significant morbidity and mortality. Polyarticular septic arthritis (PASA) accounts for 15% of all infectious arthritides and rarely occurs in immunocompetent ...
Annelise Miller, Fahad Abduljabbar, Peter Jarzem   +2 more
doaj   +1 more source

Limbus vertebrae of the cervical spine: A case report

Clinical Case Reports, 2022
Limbus vertebra is a common radiological finding in an adult, especially in the mid‐lumbar region. However it is less commonly seen in the mid cervical region.
Eleni Pappa, Ioannis Chatzikomninos
doaj   +1 more source

A Novel Technique for Reduction of Spondyloptosis with Minimal Access Surgery (MIS-TLIF): A Case Report [PDF]

Journal of Minimally Invasive Spine Surgery and Technique, 2020
To describe a technique for reduction of spondyloptosis with minimal access surgery. A 40-year-old female with BMI of 31.29 presented with chronic back pain and claudicant right L5 dermatomal pain (VAS 9/10) and paresthesia.
Arvind Gopalrao Kulkarni, Shrikant S Sagane   +1 more
doaj   +1 more source

Addressing the Diagnostic Odyssey for Adults With Neurodevelopmental Disabilities: Case Study of an Individual With Mandibulofacial Dysostosis With Microcephaly

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Whole exome sequencing (WES) has been widely used in the pediatric setting to increase diagnostic yield, provide treatment options, and to estimate reoccurrence risks. However, there is limited knowledge regarding the utility of this technology in adults with neurodevelopmental disabilities.
Ruhi Shah, Neora Shifrin, Mary Ellen Keogh, Elaine Marchi, Maureen Gavin, Karen Amble, Gholson J. Lyon   +6 more
wiley   +1 more source