Results 31 to 40 of about 104,173 (218)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Advisor-advisee relationship and the organizational culture of doctoral programs on doctoral students’ mental health and academic performance: A scoping review protocol

MethodsX
Doctoral students’ mental health is increasingly recognized as a critical issue in academia, with advisor-advisee relationships playing a key role in both well-being and academic performance.
Beatriz Cintra Storti, Jorge Sinval, Yasmin Lynda Munro, Francisco J. Medina, Marina Greghi Sticca   +4 more
doaj   +1 more source

How to write a scoping review? – A comprehensive guide

Endodontology, 2023
Systematic reviews occupy a higher order of hierarchy in the evidence pyramid; however, certain questions are left unanswered since a quantitative synthesis is difficult to achieve when there is limited and heterogeneous data. The scoping reviews thereby
Alpa Gupta, Arundeep Singh, Kritika Aneja, Vivek Aggarwal, Jitesh Wadhwa, Dax Abraham   +5 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Global mapping of physical activity promotion strategies in Fibromyalgia- A comprehensive methodological scoping review protocol

MethodsX
Fibromyalgia Syndrome (FMS) is a chronic, broad, diffuse, and non-inflammatory musculoskeletal condition. Several studies were conducted on the effects of physical activity (PA) and strategies to promote it in people with FMS.
Saumya Srivastava, Aishwarya Nair, Dhanesh Kumar K U, Rakesh Krishna Kovela, Vaishali K, Ashwani Verma, Mukesh Kumar Sinha   +6 more
doaj   +1 more source

Experimental assessment of thermal sensation and thermal comfort of sedentary subjects: a scoping review protocol

International Journal of Occupational and Environment Safety, 2020
Thermal comfort affects satisfaction in the workplace, which impacts work efficiency and productivity. Since office workers spend most of their working hours performing sedentary tasks, a scoping review is proposed to contextualize how thermal sensation ...
Daniele Costa, J. C. Guedes, J. Santos Baptista   +2 more
doaj   +1 more source

Barriers, facilitators and implementation strategies for guideline-adherence in physiotherapy: a scoping review protocol

BMJ Open, 2023
Introduction Guideline-adherent physiotherapy can improve patient outcomes and reduce costs in the healthcare system. However, although there are numerous guidelines for physiotherapy practice, services are not consistently based on clinical practice ...
Nils L Reiter, Diane Rosen, Michael Erhart, Barbara Vogel   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source