Results 121 to 130 of about 1,836,547 (316)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Optimization and Sensitivity Analysis of Computer Simulation Models by the Score Function Method.

Experimental Design;Simulation;Optimization;Queueing ...
Kleijnen, J.P.C., Rubinstein, R.Y.
core   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Higher-order circular intuitionistic fuzzy time series forecasting methodology: Application of stock change index

Demonstratio Mathematica
This article presents a higher-order circular intuitionistic fuzzy time series forecasting method for predicting the stock change index, which is shown to be an improvement over traditional time series forecasting methods.
Ashraf Shahzaib, Sohail Muhammad, Chohan Muhammad Shakir, Paokanta Siriluk, Park Choonkil   +4 more
doaj   +1 more source

Circular Intuitionistic Fuzzy Soft Set Theoretic Approach to Decision Making Problems

IEEE Access
Molodtsov introduced soft set theory as a versatile mathematical tool for handling uncertainty. However, classical soft sets may not effectively address imprecise and fuzzy parameters.
Adithya Unni, Sunil Jacob John, T. Baiju
doaj   +1 more source

Function Call Graph Score for Malware Detection

, 2015
Metamorphic malware changes its internal structure with each infection, while maintaining its core functionality. Detecting such malware is a challenging research problem.
Rajeswaran, Deebiga
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Improved protein model quality assessments by changing the target function

, 2018
Protein modeling quality is an important part of protein structure prediction. We have for more than a decade developed a set of methods for this problem.
David Menéndez Hurtado, Elofsson, Ame,, Menendez Hurtado, David,, Nanjiang Shu, Karolis Uziela, Uziela, Karolis,, Shu, Nanjiang,, Arne Elofsson, Wallner, Björn,, Wallner, Björn, Björn Wallner   +10 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source