Genotype-Based Score Test for Association Testing in Families. [PDF]
Stat Biosci, 2015 Uh HW +3 more
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
A Statistical Analysis of Vietnamese High School English Test Score Data
Vietnam Journal of EducationThis statistical study, perhaps the first of its kind in Vietnamese academia, has tried to understand the patterns in high school students’ pre-college national exam test scores which hold tremendous significance in students’ college or university ...
Thai Ton Duong Duong +2 more
doaj
A New Variance Component Score Test for Testing Distributed Lag Functions with Applications in Time Series Analysis. [PDF]
Stat Probab Lett, 2017 Chen YH, Mukherjee B.
europepmc +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
A score test for comparing cross-sectional survival data with a fraction of non-susceptible patients and its application in clinical immunology. [PDF]
PLoS One, 2017 Jonas SF +3 more
europepmc +1 more source
Aerial view of the concrete tractor test track and east campus of the University of Nebraska-Lincoln looking toward the southeast.
Nebraska Tractor Test Laboratory
core
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
The Weighting is the Hardest Part: On the Behavior of the Likelihood Ratio Test and the Score Test Under a Data-Driven Weighting Scheme in Sequenced Samples. [PDF]
Twin Res Hum Genet, 2017 Minică CC +7 more
europepmc +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source