Results 201 to 210 of about 571,313 (302)

Optimal Dose and Safety of Intravenous Favipiravir in Hospitalized Patients With COVID‐19: A Dose‐Escalating, Randomized Controlled Phase Ib Study

Clinical Pharmacology &Therapeutics, EarlyView.
AGILE (NCT04746183) is a Phase Ib/IIa platform, evaluating candidates to treat COVID‐19. Candidate Specific Trial 6 evaluated the safety and optimal dose of a novel intravenous formulation of favipiravir in a dose‐escalating, open‐label, randomized, controlled, Bayesian adaptive Phase Ib trial.
Tim Rowland, Richard FitzGerald, Elizabeth Challenger, Laura Dickinson, Laura J. Else, Lauren Walker, Colin Hale, Victoria Shaw, Callum Kelly, Rebecca Lyon, Jennifer Gibney, Karim Dhamani, Margaret Irwin, Yvanne Enever, Michelle Tetlow, William Wood, Helen Reynolds, Justin Chiong, Orod Osanlou, Henry Pertinez, Katie Bullock, William Greenhalf, Andrew Owen, David G. Lalloo, Michael Jacobs, Julian A. Hiscox, Thomas Jaki, Pavel Mozgunov, Geoffrey Saunders, Gareth Griffiths, Saye H. Khoo, Thomas E. Fletcher, on behalf of the AGILE CST‐6 Study Group, Shazaad Ahmad, Christopher J. Edwards, Lesley Dry, Georgie McKenzie, Aleksandra Ros, Michael Stackpoole, Laura Bradley, Karen Jennings‐Wilding, Nicholas Paton, Fred Hayden, Janet Darbyshire, Amy Lucas, Ulrika Lorch, Andrew Freedman, Richard Knight, Steven Julious   +48 more
wiley   +1 more source

Inherited retinal disorders in Scotland: A 5 year assessment. [PDF]

Eye (Lond)
Hazelwood JE, Sevgi M, Osborne F, Staniszewski B, George N, Ionean A, Gilmour DF, Megaw R.   +7 more
europepmc   +1 more source

Butterflies of curriculum realisation: Investigating early implementation of the Curriculum for Wales

The Curriculum Journal, EarlyView.
Abstract Curriculum reform provides a vital opportunity for nations to ensure learners are equipped to fully participate as citizens in the 21st century. This paper presents an understanding of educators’ response to curriculum reform, and some of its enablers and barriers.
Alison Glover, Claire Sinnema, Sam McAlister‐Wilson, Nia Cole‐Jones, Brett Duggan, Hefin Thomas   +5 more
wiley   +1 more source

Classroom boundaries and teacher agency: Challenges of implementing Ireland's new primary curriculum

The Curriculum Journal, EarlyView.
Abstract This article reports on a doctoral study examining teacher agency in one Irish primary school at a timely moment ahead of the implementation of the new Primary Curriculum Framework in September 2025. The framework embeds teacher agency as a central professional principle, yet findings from this study reveal a more cautious and bounded reality.
Máiréad Nally, Carmel O. Sullivan, Karin Bacon   +2 more
wiley   +1 more source

Exploring Scottish addiction services: provider-based stigma, addiction aetiology beliefs, treatment bias, and burnout among addiction treatment providers. [PDF]

Subst Abuse Treat Prev Policy
Ciesluk B, Inglis G, Parke A, Troup LJ.
europepmc   +1 more source

Habitat complexity and prey composition shape an apex predator's habitat use across contrasting landscapes

Ecography, EarlyView.
The spatial ecology of stalk‐and‐ambush predators like the Eurasian lynx Lynx lynx depends on prey availability and environmental features, yet the relative roles of these factors remain unclear at large spatial scales. In this study, we analysed lynx habitat use across central and southern Finland using snow‐track data from the Wildlife Triangle ...
Francesca Malcangi, Caio Graco‐Roza, Andreas Lindén, Janne Sundell, John Loehr   +4 more
wiley   +1 more source

Study protocol for optimising antipsychotic prescribing among hospitalised patients in the acute care setting in Scotland: a national retrospective cohort study. [PDF]

BMJ Open
Goswami C, Mueller T, Wall A, Johnson CF, Grosset D, Bennie M, Kurdi A.   +6 more
europepmc   +1 more source

Harnessing the power of machine and deep learning for transferring joint species distribution models considering the structure of biotic interactions

Ecography, EarlyView.
The transferability of single or joint species distribution models ((j)SDMs) depends on their ability to predict beyond the observed environmental range and to remain consistent despite shifts in biotic interactions. Transfer accuracy may be improved by recent advances in the application of deep learning that provide greater flexibility and potentially
Marco Basile, Maximilian Pichler, Francesco Valerio, Lorenzo Balducci, Francesco Chianucci, Sérgio Godinho, Francesco Rota, Frédéric Archaux, Christophe Bouget, Gediminas Brazaitis, Thomas Campagnaro, Ettore D'Andrea, Luc De Keersmaeker, Wouter Dekoninck, Pallieter De Smedt, Zoltán Elek, Itziar García‐ Mijangos, Frédéric Gosselin, Marion Gosselin, Andrin Gross, Elena Haeler, Sebastian Kepfer‐ Rojas, Nathalie Korboulewsky, Daniel Kozák, Thibault Lachat, Carlos Miguel Landivar Albis, Anja Leyman, Xiang Liu, Anders Mårell, Radim Matula, Martin Mikoláš, Péter Ódor, Yoan Paillet, Kastytis Šimkevičius, Tommaso Sitzia, Silvia Stofer, Nicolas Strebel, Miroslav Svoboda, Flóra Tinya, Mariana Ujházyová, Kris Vandekerkhove, Kris Verheyen, Michael Wohlwend, Fotios Xystrakis, Sabina Burrascano   +44 more
wiley   +1 more source

Patients' experiences of managing their rare rheumatic disease. [PDF]

Rheumatology (Oxford)
Dures E, Almeida C, Janjua S, Hunt A, Orme J, Lanyon PC, Walsh N, Robson JC.   +7 more
europepmc   +1 more source

Temporal shifts in kelp forest structure and distribution largely reflect recent ocean warming trends

Ecography, EarlyView.
Ocean warming is driving the redistribution of species at a global scale. Biogeographic transition zones are hotspots of species range shifts, as both warm‐ and cold‐adapted species are found toward contrasting range edges. While anecdotal evidence suggests some distributional shifts have occurred in the northeast Atlantic, the empirical evidence base ...
Nora Salland, Catherine M. Wilding, Cristina Galobart, Kathryn E. Smith, Nathan G. King, Michael T. Burrows, Dan A. Smale   +6 more
wiley   +1 more source