Results 121 to 130 of about 2,391,830 (288)

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

open access: yesAdvanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo   +17 more
wiley   +1 more source

Systemic evaluation of effect and safety of Guasha therapy for neck and shoulder pain

open access: yesHuli yanjiu, 2018
Objective:To systematically evaluate the therapeutic effect and safety of scraping on neck and shoulder pain,and provide evidencebased evidences for clinical promotion of scraping therapy.Methods:The literatures of randomized controlled trials(RCTs) of ...
姚芳, 薛莲, 严杰, 俞红
doaj  

OT outlook (Online); OT newsletter

open access: yes, 2003
Electronic coverage as of Dec. 30, 2003: Vol. 1, no. 1 (spring 2001)-; Description based on: Vol. 2, issue 1 (winter 2003); title from caption (viewed Dec.
Ohio Occupational Therapy, Physical Therapy, and Athletic Trainers Board. Occupational Therapy Section.
core  

What's in a name? : titles used in diversional therapy

open access: yes, 2020
After being involved in numerous discussions and debates over decades a question that is constantly asked by people in our field of practice is what title should we use?
Alford, Stewart (R19505)   +1 more
core  

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

open access: yesAdvanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang   +14 more
wiley   +1 more source

Observation on curative effect of scraping for treatment of postinfections lough

open access: yesHuli yanjiu, 2016
Objective:To probe into the clinical effect of scraping for postinfections cough,PIC.Methods:A total of 70 cases of patients with PIC were selected and randomly divided into two groups,35 cases in each.The patients in control group received the ...
胡倩, 孟方, 段培蓓, 王秋琴
doaj  

Web Scraping: An Analysis of Automated Retrieval of Retrocomputing Information

open access: yes
openNel contesto dinamico della rapida evoluzione tecnologica, la conservazione e la comprensione del patrimonio informatico del passato diventano aspetti fondamentali.
FRANCESCHINI, FILIPPO
core  

Modulating Calcium Homeostasis via a Biomimetic Scaffold to Rescue Diabetic Ischemic Wounds

open access: yesAdvanced Science, EarlyView.
This strategy addresses impaired microcirculation and loss of extracellular matrix (ECM) guidance in diabetic wound healing. Musc@CP, a nanofibrous dressing combining an ECM‐mimetic chitosan‐pullulan scaffold with muscone, enhances perfusion by attenuating intracellular Ca2+ overload‐associated endothelial dysfunction.
Xiang Zheng   +14 more
wiley   +1 more source

Agent‐Based Simulations of Lung Tumor Evolution Suggest That Ongoing Cell Competition Drives Realistic Clonal Expansions

open access: yesAdvanced Science, EarlyView.
Computational simulations of tumor evolution are increasingly used to infer the rules underlying cancer growth, with the goal of one day recommending tailored treatments. Here we show that the properties of lung cancer sequencing data are best replicated by a model which assumes that cells compete both to proliferate and survive. ABSTRACT Computational
Helena Coggan   +5 more
wiley   +1 more source

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

open access: yesAdvanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu   +7 more
wiley   +1 more source

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