Results 51 to 60 of about 2,391,830 (288)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
中西医结合护理, 2023 This paper reviewed the effect of Traditional Chinese Medicine holographic scraping combined with moxibustion therapy on a patient with renal malignant tumor who had diarrhea adverse reaction of targeted therapy and immunotherapy, and summarized the ...
JI Yunfei (吉云飞) +5 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
中西医结合护理, 2022 This paper reported the Traditional Chinese Medicine (TCM) holographic scraping therapy and related nursing management for a patient with functional constipation.
JIA Zongyi (贾宗祎) +2 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
中西医结合护理, 2023 This article summarized the practice of nursing ward rounds in a patient with cancer-related pain treated with holographic scraping combined with five-tone therapy.
FANG Yun (方云) +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
中西医结合护理This article summarizes nursing practice of a patient with decompensated liver cirrhosis (liver depression and spleen deficiency type) who received comprehensive auricular acupoint therapy combined with guided music imagination technology to improve ...
LIAN Xiaojing (廉晓静) +3 more
doaj +1 more source
中西医结合护理, 2023 This paper summarized the nursing of a patient with coronary heart disease treated with scrapping combined with auricular acupoint pressing therapy based on the theory of combining with disease and syndrome.
YANG Lili (杨丽丽) +3 more
doaj +1 more source