Results 61 to 70 of about 2,391,830 (288)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Analysis of clinical disease spectrum of single scraping therapy based on bibliometrics

Huli yanjiu, 2019
Objective:To summarize the clinical spectrum of single scraping therapy,analyze its characteristics and research trends,and provide reference for the clinical use of single scraping therapy to treat diseases.Methods:Computer search of China Knowledge ...
杨敏, 岳容兆, 张沁, 陈丽虹, 徐桂华   +4 more
doaj  

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Other title: What does the Occupational Therapy, Physical Therapy, and Athletic Trainers Board say about telehealth?

, 2020
"Created: 3/16/2020..."--Document properties ...
Ohio Occupational Therapy, Physical Therapy, and Athletic Trainers Board
core  

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Treatment planning study comparing proton therapy, RapidArc and intensity modulated radiation therapy for a synchronous bilateral lung cancer case

, 2014
Purpose: The main purpose of this study is to perform a treatment planning study on a synchronous bilateral non-small cell lung cancer case using three treatment modalities: uniform scanning proton therapy, RapidArc, and intensity modulated radiation ...
Zheng, Yuanshui; Department of Medical Physics, ProCure Proton Therapy Center, Oklahoma City, OK, USA., Zhao, Li; Department of Medical Physics, ProCure Proton Therapy Center, Oklahoma City, OK, USA., Risalvato, Dina; Department of Medical Dosimetry, ProCure Proton Therapy Center, Oklahoma City, Oklahoma, USA., Vargas, Carlos; Radiation Oncology, Proton Collaborative Group (PCG), Bloomington, Indiana, USA., Rana, Suresh; Department of Medical Physics, ProCure Proton Therapy Center, Oklahoma City, OK, USA., Pokharel, Shyam; Department of Medical Physics, 21st Century Oncology, Fort Myers, Florida, USA., Cersonsky, Nancy; Department of Radiation Oncology, ProCure Proton Therapy Center, Oklahoma City, Oklahoma, USA.   +6 more
core   +1 more source

Impact of heterogeneities on lateral penumbra in uniform scanning proton therapy [PDF]

, 2013
Purpose: In the treatment planning of uniform scanning proton therapy, an aperture block is designed for each beam with a margin, which typically includes the lateral penumbra measured in water (homogenous) medium.
Rana, Suresh; Department of Medical Physics, ProCure Proton Therapy Center, Oklahoma City, Singh, Hardev; Department of Medical Physics, ProCure Proton Therapy Center, Oklahoma City   +1 more
core   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Skin Scrape Cytology in the Diagnosis of Nodular Basal Cell Carcinoma for Treatment by Photodynamic Therapy

Acta Dermato-Venereologica, 1999
Photodynamic therapy is a new mode of cancer treatment with promising results for basal cell carcinoma. The current study aims to investigate the accuracy of skin scrape cytology in the diagnosis of basal cell carcinoma as an integrated part of the treatment procedure.
A, Berner, A, Soler, T, Warloe
openaire   +2 more sources