Results 61 to 70 of about 38,378 (295)

The kinesin Eg5 inhibitor K858 induces apoptosis but also survivin-related chemoresistance in breast cancer cells [PDF]

, 2016
Inhibitors of kinesin spindle protein Eg5 are characterized by pronounced antitumor activity. Our group has recently synthesized and screened a library of 1,3,4-thiadiazoline analogues with the pharmacophoric structure of K858, an Eg5 inhibitor.
CARRADORI, Simone, DE IULIIS, FRANCESCA, giantulli, sabrina, GIUFFRIDA, Anna, MILANA, Bernardina, SALERNO, GERARDO, SCARPA, Susanna, SILVESTRI, Ida, Taglieri, Ludovica   +8 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Traditional Chinese Medicine holographic scraping combined with moxibustion in the treatment of targeted therapy and immunotherapy-associated diarrhea in a patient with renal cell carcinoma (中医全息刮痧联合艾灸治疗1例肾恶性肿瘤患者靶向治疗和免疫治疗相关腹泻的护理体会)

中西医结合护理, 2023
This paper reviewed the effect of Traditional Chinese Medicine holographic scraping combined with moxibustion therapy on a patient with renal malignant tumor who had diarrhea adverse reaction of targeted therapy and immunotherapy, and summarized the ...
JI Yunfei (吉云飞), LI Xu (李旭), SONG Libo (宋丽波), LI Mingzhu (李明珠), SONG Henan (宋鹤楠), ZHANG Miao (张淼)   +5 more
doaj   +1 more source

View 1: Corneal scraping and combination antibiotic therapy is indicated [PDF]

British Journal of Ophthalmology, 2003
Microbial keratitis is an ocular emergency that requires prompt and appropriate management to ensure the best visual outcome for the patient. If possible, this means identification of the causative organism(s) and selection of the best antimicrobial agent(s) to treat the patient.
openaire   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Nursing of a patient with functional constipation treated by Traditional Chinese Medicine holographic scraping (中医全息刮痧治疗功能性便秘1例的护理)

中西医结合护理, 2022
This paper reported the Traditional Chinese Medicine (TCM) holographic scraping therapy and related nursing management for a patient with functional constipation.
JIA Zongyi (贾宗祎), HU Hairong (胡海荣), TANG Ling (唐玲)   +2 more
doaj   +1 more source

Making Public Media Personal: Nostalgia and Reminiscence in the Office

, 2011
In this paper we explore the notion of creating personally evocative collections of content from publicly available material. Compared to the personal media that we look at, reminisce over, or personalise our offices with, public media offers the ...
André, Paul, schraefel, m.c., Sellen, Abigail, Wood, Ken   +3 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Nursing ward rounds in a patient with cancer-related pain treated with holographic scraping combined with five-tone therapy (全息刮痧联合五音疗法治疗癌性疼痛1例的护理查房体会)

中西医结合护理, 2023
This article summarized the practice of nursing ward rounds in a patient with cancer-related pain treated with holographic scraping combined with five-tone therapy.
FANG Yun (方云), LI Ye (李野), ZHAO Yan (赵燕), XU Lan (徐兰)   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source