Results 81 to 90 of about 578,337 (285)
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source
Jurnal PaedagogyThis study aims to develop scratch-based educational game media to enhance Natural Sciences and Social Sciences (IPAS) Learning Outcomes in Elementary School. The research uses a Research and Development method with the ADDIE model, which has five stages,
Maya Nur Amalia, Sri Sukasih
doaj +1 more source
An Approach to Evaluate the Complexity of Block-Based Software Product
Informatics in Education, 2020 Computer programming skills have been growing as a professional competence also to unqualified end-users who need to develop software in their professional practice. Quality evaluation models of end-user-developed products are still scarce. In this paper,
Ilenia FRONZA, Luis CORRAL, Claus PAHL
doaj +1 more source
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Uncovering the truth about cat-scratch disease
Open Veterinary JournalCat-scratch disease (CSD) is a systemic infection caused by the facultative, rod-shaped, non-motile, Gram-negative, intracellular zoonotic bacillus Bartonella henselae. The bacteria that cause CSD were not discovered until decades after the condition was
Yulianna Puspitasari +15 more
doaj +1 more source
Arthritis Care &Research, EarlyView.Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo +88 more
wiley +1 more source
Jurnal Pendidikan Matematika (JPM)The development of Scratch-based Math Case interactive learning media uses the Research & Development method which produces an interactive learning media that can be accessed without using an application.
Nabilah Az-zahrah +5 more
doaj +1 more source