Results 61 to 70 of about 189,519 (302)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

EFFECT OF MAGNETIC FIELD ON THE FRICTION AND WEAR DISPLAYED BY THE SCRATCH OF OIL LUBRICATED STEEL [PDF]

Journal of the Egyptian Society of Tribology, 2012
The present work discusses the effect of magnetic field on the friction and wear of steel scratched by TiC insert. The steel was lubricated by oil and dispersed by iron, copper and aluminium powders as well as polymeric powders such as high density ...
A. Alahmadi, W. Y. Ali, M. K. Mohamed, S. Abdel-Sattar   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

TRIBOLOGICAL PROPERTIES OF EPOXY COMPOSITES [PDF]

Journal of the Egyptian Society of Tribology, 2016
The present work investigates the influence of the addition of nanoparticles to epoxy on the tribological properties, such as friction coefficient and wear resistance.
A. H. Badran, M. K. Hasan, W. Y. Ali
doaj   +1 more source

Scratch evaluation on a high performance polymer [PDF]

, 2013
The authors wish to thank the participating communities, the Laboratory of Mechanics surfaces and materials processing, University Lille for the access and 84 usage of its research facility.
RODRIGUEZ, Vanessa, PEREZ DELGADO, Yeczain, IOST, Alain, STAIA, Mariana, SUKUMARAN, Jacob, DE BAETS, Patrick, Rodriguez Fereira, Vanessa   +6 more
core  

Implementation of the Scratch programming language from the DUA principles for the strengthening of geometric competences in the Liceo Campestre Cafam School

, 2022
El presente es un estudio de enfoque mixto, tipo exploratorio que tiene como objetivo general Implementar una secuencia didáctica basada en el lenguaje de programación Scratch con aportes del DUA para favorecer el desarrollo de competencias geométricas ...
Rodríguez Navarrete, Leonel Alberto
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Scratch-Assisted Interactive Learning Media for Fraction Learning: A Development Study on Fourth-Grade Students’ Mathematical Representation Skills

Jurnal Kependidikan
This study aims to develop interactive learning media based on the Scratch website, designed according to the learning needs and mathematical representation abilities of fourth-grade elementary school students on the topic of fractions.
Alya Wahyu Kartika, Trimurtini
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source