Results 61 to 70 of about 578,337 (285)

A nanometric cushion for enhancing scratch and wear resistance of hard films

open access: yesBeilstein Journal of Nanotechnology, 2014
Scratch resistance and friction are core properties which define the tribological characteristics of materials. Attempts to optimize these quantities at solid surfaces are the subject of intense technological interest.
Katya Gotlib-Vainshtein   +4 more
doaj   +1 more source

When Developing a Career Path, What are the Key Elements to Include? [PDF]

open access: yes, 2013
Question: When developing a career path from scratch, what are the key elements to include in the design process and what factors lead to a successful ...
Cao, Jing, Thomas, Desiree
core   +1 more source

Learning Language Games through Interaction

open access: yes, 2016
We introduce a new language learning setting relevant to building adaptive natural language interfaces. It is inspired by Wittgenstein's language games: a human wishes to accomplish some task (e.g., achieving a certain configuration of blocks), but can ...
Liang, Percy   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Friction Analysis on Scratch Deformation Modes of Visco-Elastic-Plastic Materials [PDF]

open access: yes, 2012
Understanding of abrasion resistance and associated surfaces deformation mechanisms is of primary importance in materials engineering and design. Instrumented scratch testing has proven to be a useful tool for characterizing the abrasion resistance of ...
Budi , Setiyana   +3 more
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

FRICTION ANALYSIS ON SCRATCH DEFORMATION MODES OF VISCO-ELASTIC-PLASTIC MATERIALS

open access: yesReaktor, 2013
Understanding of abrasion resistance and associated surfaces deformation mechanisms is of primary importance in materials engineering and design. Instrumented scratch testing has proven to be a useful tool for characterizing the abrasion resistance of ...
Budi Setiyana   +3 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Scratch. [PDF]

open access: yes, 2008
Scratch investigated the use of physical space as a site and representation of narrative and dramatic structure. It was commissioned by and collaboratively developed with BBC Radio Drama.
BBC   +7 more
core  

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