Results 41 to 50 of about 189,519 (302)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

PENSAMIENTO LÓGICO MATEMÁTICO CON SCRATCH EN NIVEL BÁSICO [PDF]

, 2013
El siglo XXI exige una sólida formación integral en donde la educación sin duda representa una parte fundamental para el desarrollo cognitivo permitiendo la adquisición de conocimientos teóricos y prácticos que faciliten un aprendizaje autentico que ...
Salgado, Victor Campos, Valle, Jose Efren Marmolejo   +1 more
core   +2 more sources

Optimizing intrauterine insemination: A systematic review and meta‐analysis of the effectiveness and safety of clinical treatment add‐ons

Acta Obstetricia et Gynecologica Scandinavica
Introduction Intrauterine insemination (IUI) is one of the most widespread fertility treatments. However, IUI protocols vary significantly amongst fertility clinics. Various add‐on interventions have been proposed to boost success rates. These are mostly
Elpiniki Chronopoulou, Andrea Gaetano‐Gil, Sadaf Shaikh, Claudia Raperport, Bassel H. Al Wattar, Gabriel Ruiz‐Calvo, Javier Zamora, Priya Bhide   +7 more
doaj   +1 more source

Scratch na universidade/ Scratch at the university

Brazilian Applied Science Review, 2019
O projeto foi desenvolvido na Universidade Federal de Uberlândia, no Campus Pontal, vinculado ao PROSSIGA-2019. O intuito da ação foi promover uma melhoria no pensamento lógico dos alunos através de uma programação simplificada e interativa (Scratch). Para isso, mediante a divulgação de um curso, foram ministradas aulas durante cinco semanas, focadas ...
Tozzi, Yago Louzada, Vieira, Pedro Henrique, Altomani, Renan Spina, Piovezan, Thaina, Venturini, Patricia Cristina   +4 more
openaire   +3 more sources

Hardness and scratch response of PVD multilayer coatings [PDF]

, 2009
In the present investigation, novel Cr/CrN, CrN/CrAlN and Cr/CrN/CrAlN multilayered coatings thin films have been developed by dual RF magnetron sputtering.
LAMBERTIN, Michel, NOUVEAU, Corinne, BENLATRECHE, Yacine, MUSTAPHA, Nasri, TLILI, Brahim   +4 more
core  

Frame-Based Editing: Easing the Transition from Blocks to Text-Based Programming [PDF]

, 2015
Block-based programming systems, such as Scratch or Alice, are the most popular environments for introducing young children to programming. However, mastery of text-based programming continues to be the educational goal for stu- dents who continue to ...
Neil C. C. Brown, Brown, Neil C.C., Amjad Altadmri, Altadmri, Amjad, Michael Kölling, Kölling, Michael   +5 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Children’s Civic Engagement in the Scratch Online Community

Social Sciences, 2016
In public discourse, and in the governance of online communities, young people are often denied agency. Children are frequently considered objects to protect, safeguard, and manage.
Ricarose Roque, Sayamindu Dasgupta, Sasha Costanza-Chock   +2 more
doaj   +1 more source

Evoluzione dei linguaggi di programmazione educativi: Scratch e B.Y.O.B. [PDF]

, 2022
In questa tesina si parla dei linguaggi di programmazione educativi, cioè linguaggi utilizzati nelle scuole per insegnare i concetti dell’informatica e non solo ai ragazzi. In particolare analizziamo Scratch e BYOB.
Avdic, Almir
core