Results 41 to 50 of about 115,255 (264)

Children’s Civic Engagement in the Scratch Online Community

Social Sciences, 2016
In public discourse, and in the governance of online communities, young people are often denied agency. Children are frequently considered objects to protect, safeguard, and manage.
Ricarose Roque, Sayamindu Dasgupta, Sasha Costanza-Chock   +2 more
doaj   +1 more source

Scratch na universidade/ Scratch at the university

Brazilian Applied Science Review, 2019
O projeto foi desenvolvido na Universidade Federal de Uberlândia, no Campus Pontal, vinculado ao PROSSIGA-2019. O intuito da ação foi promover uma melhoria no pensamento lógico dos alunos através de uma programação simplificada e interativa (Scratch). Para isso, mediante a divulgação de um curso, foram ministradas aulas durante cinco semanas, focadas ...
Tozzi, Yago Louzada, Vieira, Pedro Henrique, Altomani, Renan Spina, Piovezan, Thaina, Venturini, Patricia Cristina   +4 more
openaire   +3 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Optimizing intrauterine insemination: A systematic review and meta‐analysis of the effectiveness and safety of clinical treatment add‐ons

Acta Obstetricia et Gynecologica Scandinavica
Introduction Intrauterine insemination (IUI) is one of the most widespread fertility treatments. However, IUI protocols vary significantly amongst fertility clinics. Various add‐on interventions have been proposed to boost success rates. These are mostly
Elpiniki Chronopoulou, Andrea Gaetano‐Gil, Sadaf Shaikh, Claudia Raperport, Bassel H. Al Wattar, Gabriel Ruiz‐Calvo, Javier Zamora, Priya Bhide   +7 more
doaj   +1 more source

A Dialogue Between Computational Thinking and Interdisciplinarity using Scratch Software

Uni-pluriversidad, 2020
In this paper, the purpose is to discuss results of a continuing education action with tea-chers, linked to the university extension project Computational Thinking and Interdisciplina-rity in the classroom, developed within the Postgraduate Program in ...
Maria Teresa Zampieri, Sueli Liberatti Javaroni   +1 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

An Approach to Evaluate the Complexity of Block-Based Software Product

Informatics in Education, 2020
Computer programming skills have been growing as a professional competence also to unqualified end-users who need to develop software in their professional practice. Quality evaluation models of end-user-developed products are still scarce. In this paper,
Ilenia FRONZA, Luis CORRAL, Claus PAHL
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source