Results 51 to 60 of about 189,519 (302)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

The Basics of Scratching

open access: yesJournal of New Music Research, 2002
This article deals with the popular and rarely studied art form of manipulating a vinyl record by rhythmically dragging and pushing it, commonly labelled “scratching.” With sufficient practice, a Disc Jockey (DJ) can have great control over the sound produced and treat the turntable as an expressive musical instrument. Even though a digital-based model
openaire   +3 more sources

The Greenfoot Programming Environment [PDF]

open access: yes, 2010
Greenfoot is an educational integrated development environment aimed at learning and teaching programming. It is aimed at a target audience of students from about 14 years old upwards, and is also suitable for college- and university-level education ...
Michael Kölling, Kölling, Michael
core   +1 more source

Scratch test results for Dunnville sandstone

open access: yes, 2022
These experimental data from scratch tests on Dunnville sandstone consists of video files, force signal files and particle data file. Both the force signals and videos files are from two rounds of scratch tests.
Detournay, Emmanuel   +2 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

A Dialogue Between Computational Thinking and Interdisciplinarity using Scratch Software

open access: yesUni-pluriversidad, 2020
In this paper, the purpose is to discuss results of a continuing education action with tea-chers, linked to the university extension project Computational Thinking and Interdisciplina-rity in the classroom, developed within the Postgraduate Program in ...
Maria Teresa Zampieri   +1 more
doaj   +1 more source

Scratch test results for Alabama marble

open access: yes, 2022
These experimental data from scratch tests on Alabama marble consists of video files, force signal files and particle data file. Both the force signals and videos files are from three rounds of scratch tests.
Detournay, Emmanuel   +2 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

An Approach to Evaluate the Complexity of Block-Based Software Product

open access: yesInformatics in Education, 2020
Computer programming skills have been growing as a professional competence also to unqualified end-users who need to develop software in their professional practice. Quality evaluation models of end-user-developed products are still scarce. In this paper,
Ilenia FRONZA, Luis CORRAL, Claus PAHL
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

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