Porcine kidney xenotransplantation: From primate models to clinical reality
Animal Models and Experimental Medicine, EarlyView.In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo +3 more
wiley +1 more source
Drug-herb interactions: a challenge and clinical concern in primary healthcare. [PDF]
Front Med (Lausanne)M S, Puthiyedath R, Pillai ZS.
europepmc +1 more source
Clotrimazole‐loaded PLGA microparticles for local drug delivery to the vagina: Shape does matter
Animal Models and Experimental Medicine, EarlyView.Clotrimazole‐loaded PLGA microparticles for intravaginal delivery. Abstract Background Intravaginal drug administration is the most promising strategy for treating vaginal infections to protect women's health, such as vulvovaginal candidiasis (VVC). However, conventional vaginal formulations in the clinic face challenges such as drug leakage and low ...
Yanyu Li +8 more
wiley +1 more source
Denoising eye movement signals using a novel signal processing framework to preserve oculomotor integrity in dyslexia. [PDF]
Sci RepGajendiran S, Sivagnanam Y.
europepmc +1 more source
Animal Models and Experimental Medicine, EarlyView.7,12‐Dimethylbenz[a]anthracene (DMBA) could induce leukemia and other types of cancers in rat models. Transcriptomics revealed gene expression profile that parallels with human leukemia. DMBA‐induced differential gene expression could validate the developed rat model.
Khaldoon Alsamman, Omar S. El‐Masry
wiley +1 more source
Delirium screening and alerting systems for older hospital inpatients. [PDF]
BMC Health Serv ResBenn L +6 more
europepmc +1 more source
SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells
Animal Models and Experimental Medicine, EarlyView.The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang +6 more
wiley +1 more source
Photocatalytic Transfer Hydrogenation Using Plastic Hydrolysates as Hydrogen Donor
Angewandte Chemie, EarlyView.Plastic waste is transformed into functional amines via solar‐driven transfer hydrogenation. Soluble monomers from acid hydrolysis of waste polymers serve as a hydrogen (electron/proton)donors in the selective reduction of nitroarenes using a visible light active photocatalyst consisting of cobalt promoted molybdenum disulfide integrated in cyanamide ...
Papa K. Kwarteng +2 more
wiley +2 more sources
Alcohol use-related problems in general hospitals and primary care settings: Screening, intervention, and referral to treatment. [PDF]
World J PsychiatryLv XF, Li RH.
europepmc +1 more source
Animal Models and Experimental Medicine, EarlyView.This graphical abstract illustrates the essential role of USB1 in neutrophil maturation. In normal myeloid cells, USB1 acts as an RNA exonuclease, trimming RNA tails to maintain proper RNA network function, which supports the differentiation of myeloid progenitor cells into mature neutrophils.
Hang Li +6 more
wiley +1 more source