Results 161 to 170 of about 70,645 (215)

Clusia genomes shed light on the evolution and diversity of crassulacean acid metabolism physiotypes. [PDF]

Nat Commun
Kramml HM, Herpell JB, Priemer C, Wessely Z, Schindler F, Berger A, Kellner M, Plott S, Dohovits Á, Schmidt T, Kerpan P, Afjehi-Sadat L, Chaturvedi P, Ghatak A, Brenner M, Pierides I, Fragner L, Temsch EM, Trevisan F, Ibrahim M, Fromwald F, Bellaire A, Simakov O, Huber W, Lüttge U, Paun O, Wicke S, Weiss-Schneeweiss H, Bachmann G, Weckwerth W.   +29 more
europepmc   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Defining the influence of digitalization on the future of dentistry through an educational handbook for Computer Aided Design tool training. [PDF]

BMC Med Educ
Anghel MA, Marinescu IR, Ionescu AG, Micu D, Iliescu AA, Mărășescu PC, Uriciuc WA, Zaharia C, Petrescu SMS, Diaconu OA, Manolea HO.   +10 more
europepmc   +1 more source

A dose‐finding population pharmacokinetic/pharmacodynamic model of ginisortamab, an anti‐gremlin‐1 monoclonal antibody, in patients with solid tumours

British Journal of Clinical Pharmacology, EarlyView.
Aims Ginisortamab, a first‐in‐class human monoclonal antibody for the treatment of advanced solid tumours, binds to gremlin‐1 and restores bone morphogenetic protein signalling. We used pharmacokinetic/pharmacodynamic (PK/PD) modelling to characterize the relationship between ginisortamab dose and serum gremlin‐1 binding, using model‐based simulations ...
Yin Cheong Wong, Luisa Rojas Chavarro, Paul Jones, David Egging, Wanchana Ungphakorn, Marta Valle, Ivan Matthews   +6 more
wiley   +1 more source

The effect of using laparoscopic imaging screens of different sizes (55-inch vs. 27-inch) on surgical parameters in hysterectomy surgery: a retrospective cohort study. [PDF]

BMC Surg
Sivas MC, Aslan Cetin B, Ohanoglu Cetinel K, Geyikoglu IE.   +3 more
europepmc   +1 more source

Mind the gap: Adherence to denosumab dosing and cessation guidelines in Australian residential aged care

British Journal of Clinical Pharmacology, EarlyView.
This original research used medication administration data to explore adherence to treatment guidelines for the most common osteoporosis medications in long‐term residential aged care (RAC) in Australia. The paper highlights gaps in adherence to treatment guidelines that must be addressed to improve outcomes of older adults living in RAC.
Marea O'Donnell, Johanna I. Westbrook, Bayzidur Rahman, Isabelle Meulenbroeks, Nasir Wabe, Ian D. Cameron, Mark Morgan, Magdalena Z. Raban   +7 more
wiley   +1 more source

Informing robot design through early public engagement: lay perceptions of soft versus rigid socially assistive and rescue robots. [PDF]

Front Robot AI
Fenn J, Estadieu L, Gorki M, Monno I, Tauber F, Teichmann J, Levy-Tzedek S, Speck T, Müller O, Kiesel A.   +9 more
europepmc   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Mimic, target, and adapt: Cell membrane‐coated nanoplatforms for precision and immune‐guided cancer treatment

BMEMat, EarlyView.
This Perspective explores the emerging landscape of cell membrane‐coated nanoparticles (CM‐NPs) as intelligent, immune‐compatible platforms for cancer therapy. Highlighting design strategies, translational challenges, and competitive positioning, it outlines how integrating biomimetic targeting with advanced analytical and manufacturing tools could ...
A. K. M. M. Alam, Xiaojun Cai, Malik Ihsan Ullah Khan, Robert Musiol, Quazi T. H. Shubhra   +4 more
wiley   +1 more source

Perioperative sleep optimisation and brain health in older adults (SLEEP-BOOST): protocol for a randomised controlled trial. [PDF]

BMJ Open
Charles AE, Castillo Suárez AA, Chhajed M, Jimenez Gallardo M, Sanchez Valdes K, Li P, Hu K, Wong PM, Winkelman J, Gao L.   +9 more
europepmc   +1 more source