Results 181 to 190 of about 70,645 (215)

Isodesmic Supramolecular Assembly of Phenylethynylene Bis‐Urea Macrocycles

open access: yesChemistry – A European Journal, EarlyView.
A soluble phenylethynylene bis‐urea macrocycle assembles in polar media via an isodesmic hydrogen bonded mechanism. Spectroscopic and morphological studies reveal nanoscale aggregates with short chain length, while guest additives modulate enthalpy and polymerization, demonstrating tunable supramolecular assembly.
Fahidat A. Gbadamosi   +5 more
wiley   +1 more source

Photosensitizing Au(I) Catalysis With Coumarins

open access: yesChemistry – A European Journal, EarlyView.
A Au(I) complex with a tethered coumarin fragment was synthesized and characterized by UV‐vis and emission spectroscopy. Its ability to facilitate photo‐driven cross‐coupling reactions through single‐electron and energy transfer events was evaluated. ABSTRACT Gold catalysis shows versatility in a wide range of challenging transformations, wherein light‐
Liliana Capulín Flores   +2 more
wiley   +1 more source

Substrate‐Selective Inhibition of the SARS‐CoV‐2 Papain‐Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates

open access: yesChemistry – A European Journal, EarlyView.
The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma   +13 more
wiley   +1 more source

Smartphone Sensor Battery Consumption: A Standardized and Reproducible Test Protocol. [PDF]

open access: yesSensors (Basel)
Schweizer F   +6 more
europepmc   +1 more source

Clinical Validation of a QSP Model for ISB 2001, a Trispecific T Cell Engager to Support Optimal FIH Study Design in RRMM Patients

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
ISB 2001 is a trispecific antibody that binds to two tumor‐associated antigens (TAA), CD38 and BCMA, and crosslinks to CD3 on T cells resulting in T cell‐mediated cytotoxicity of tumor cells expressing these TAAs. ISB 2001 is currently being tested in relapsed and/or refractory multiple myeloma (RRMM) patients in the first‐in‐human (FIH) TRIgnite‐1 ...
Vinu Chandralayam Ayyappa Menon   +11 more
wiley   +1 more source

Governance for Pension Plans' Sustainable Transition: The Moderating Role of Corporate Social Identity

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Pension plans may either limit their sustainability approach to commercial purposes or adopt governance practices aligned with sustainability principles, thereby strengthening their Corporate Social Identity (CSI). This paper explores the moderating role of CSI in the relationship between traditional corporate governance mechanisms and pension
Elisa Bocchialini   +2 more
wiley   +1 more source

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