Results 111 to 120 of about 2,453,791 (290)

Lead Exposure and Prevention Advisory Committee (LEPAC) : 2022 annual report to U.S. Department of Health and Human Services [PDF]

The objective of the Lead Exposure and Prevention Advisory Committee (LEPAC) is to review research and federal programs and services related to lead poisoning and to identify effective services and best practices for addressing and preventing lead ...

core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Screen used [PDF]

'Screen Used' was a solo exhibition of new video and prints by Jane Topping. Topping's work examines the ever-developing relationship between your body and your screen.
Topping, Jane
core  

The Chain Mediating Effects of Parent–Child Conflict and Screen Time on the Relationship Between Parental Phubbing and Problem Behaviors in Preschoolers

Behavioral Sciences
This study aims to investigate the key factors contributing to parental phubbing behaviors (the combination of “phone” and “snubbing”), ultimately reducing behavioral problems and promoting healthy development among preschool children.
Qiulan Gu, Mei Zhao
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Association between short video exposure and axial length in preschool children: a cross-sectional study

Zhongguo gonggong weisheng
ObjectiveTo investigate the exposure time and content characteristics of short videos among preschool children and analyze their association with axial length, in order to provide a reference for myopia prevention and control in preschool children ...
Chenshu LI, Senlin LIN, Sha LUO, Hao CHEN, Yi SUN, Hong JIANG, Yingnan JIA   +6 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Factors associated with screen exposure in children aged 0‒3 years

Shanghai yufang yixue
ObjectiveTo investigate the screen exposure situation and its determinants among children aged 0‒3 years, so as to offer insights for intervening in children’s screen exposure.MethodsA total of 1 797 children who received routine physical examinations in
WU Changhua, YU Hong, LIU Dan
doaj   +1 more source