Results 111 to 120 of about 2,566,096 (288)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Attention deficit in children in the digital era: A cross-sectional study on the influence of parenting styles and screen exposure

Telangana Journal of Psychiatry
Background: In this digital era, children are exposed to screens instead of outdoor activities. This has raised concerns about its impact on attention spans and behavioral health.
Satya Nagisetty, Sphurti Pusukuri, Mamatha Bellamkonda, M. Vishnu Vardhan, Rajendrakumar Katte   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Screen of commensal strains for increased adherence to HT-29 cells following exposure to 6′sialyllactose.

, 2013
Screen of commensal strains for increased adherence to HT-29 cells following exposure to 6′sialyllactose.
Ludovica F. Buttó (424854), John O’Callaghan (424853), Marguerite Clyne (304068), Helen Slattery (424855), Devon W. Kavanaugh (424852), Marian Kane (424857), Lokesh Joshi (424858), Rita M. Hickey (424859), Jonathan Lane (424856)   +8 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

The Chain Mediating Effects of Parent–Child Conflict and Screen Time on the Relationship Between Parental Phubbing and Problem Behaviors in Preschoolers

Behavioral Sciences
This study aims to investigate the key factors contributing to parental phubbing behaviors (the combination of “phone” and “snubbing”), ultimately reducing behavioral problems and promoting healthy development among preschool children.
Qiulan Gu, Mei Zhao
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Association between short video exposure and axial length in preschool children: a cross-sectional study

Zhongguo gonggong weisheng
ObjectiveTo investigate the exposure time and content characteristics of short videos among preschool children and analyze their association with axial length, in order to provide a reference for myopia prevention and control in preschool children ...
Chenshu LI, Senlin LIN, Sha LUO, Hao CHEN, Yi SUN, Hong JIANG, Yingnan JIA   +6 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source