Results 91 to 100 of about 3,600,121 (311)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

BowelScreen statistical bulletin 2016-2017 [PDF]

open access: yes, 2018
The figures in this report relate to people invited by BowelScreen for screening between 1 January 2016 and 31 December 2016.
HSE National Screening Service
core  

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Expert consensus on the adjustment of blood screening strategy for alanine aminotransferase in Chinese blood donors

open access: yesZhongguo shuxue zazhi
Alanine aminotransferase (ALT), as a non-specific alternative test for hepatitis detection, was listed as a mandatory screening item for blood donors in China in the 1990s and has been continued to this day.
Blood Screening Expert Group, National Center for Clinical Laboratories
doaj   +1 more source

International Peer Review Panel Report of Quality Assurance Standards 2011 - National Colorectal Screening Programme

open access: yes, 2011
This report presents the recommendations of an international peer-review of the draft quality assurance (QA) standards that will govern the national colorectal cancer screening programme in Ireland, due to commence in ...
HSE National Screening Service
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Lack of consensus in calculation of interval cancer rates for cervical cancer screening

open access: yesActa Obstetricia et Gynecologica Scandinavica
Introduction In 2018, nondisclosure of results of retrospective audits of cytology in interval cancers precipitated a crisis in the Irish national cervical screening programme.
Patricia Fitzpatrick   +11 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

Report of the Board of the National Cancer Screening Service January 2008 to March 2010

open access: yes, 2010
Report of the Board of the National Cancer Screening Service January 2008 to March ...
National Cancer Screening Service
core  

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