FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Phase 1 implementation of nutrition screening in a Dublin acute teaching hospital
, 2014 Nutrition Screening Week results from 2010 and 2011 indicated that one in three to four patients admitted to Irish Hospitals are at risk of disease-related malnutrition, 74-75% of whom are at high risk1.
Nutrition Screening Steering Group
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Guidelines for Quality Assurance in Colorectal Screening, 2nd ed.
, 2019 Population-based screening for colorectal cancer is potentially one of the most effective public health interventions in the Irish healthcare system.3 The primary objective of colorectal cancer screening is to detect pre-cancerous adenomas in the lining ...
National Cancer Screening Service (NCSS)
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Development of a cost-effectiveness model for optimisation of the screening interval in diabetic retinopathy screening [PDF]
, 2015 BACKGROUND: The English NHS Diabetic Eye Screening Programme was established in 2003. Eligible people are invited annually for digital retinal photography screening.
Ramon Luengo-Fernandez +18 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
National Cancer Screening Service Annual Report 2007-2008
, 2008 The first annual report of the National Cancer Screening Service Board (NCSSB) which was established on 01 January ...
National Cancer Screening Service
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Minutes of the Meeting of the Steering Group for National Breast Screening Programme
, 1997 Minutes of a meeting of the Steering Group for National Breast Screening Programme ...
National Breast Screening Group
core
Breast and cervical cancer screening programme implementation in 16 countries
, 2010 Objective There is a continuing need to monitor and evaluate the impact of organized screening programmes on cancer incidence and mortality. We report results from a programme assessment conducted within the International Cancer Screening Network (ICSN ...
Ballard-Barbash, Rachel +12 more
core +1 more source