Results 181 to 190 of about 7,150,903 (384)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

P619: Three years of newborn screening for MPS1 in Ontario: Challenges of screening for the severe end of a disease continuum

Genetics in Medicine Open
Melanie Lacaria, Matthew Henderson, Ed Yeh, Sara Fernandez, Kelsey Kalbfleisch, Kristin Kernohan, Pranesh Chakraborty   +6 more
doaj   +1 more source

Sion Test: - As A Screening Test in Infertile Women before the Laparoscopy.

, 2015
Iosr Journals, G.P.N. Karunavathi, Dr Ratna   +2 more
openalex   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

P506: Long-term results and challenges of newborn screening for classic homocystinuria in New York State

Genetics in Medicine Open
Jing Xiao, Sarah Bradley, Christopher Johnson, Carlos Saavedra-Matiz, Tara Whispell, Joseph Orsini, Michele Caggana   +6 more
doaj   +1 more source

Screening for serious mental illness in the general population with the K6 screening scale: results from the WHO World Mental Health (WMH) survey initiative

International Journal of Methods in Psychiatric Research, 2010
R. Kessler, J. Green, M. Gruber, N. Sampson, E. Bromet, Marius Cuitan, T. Furukawa, O. Gureje, H. Hinkov, Chi‐yi Hu, C. Lara, Sing Lee, Z. Mneimneh, L. Myer, M. Oakley-Browne, J. Posada-Villa, R. Sagar, M. Viana, A. Zaslavsky   +18 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Green synthesis of silver nanoparticles using Tropaeolum majus : Phytochemical screening and antibacterial studies [PDF]

, 2021
Saud Bawazeer, Abdur Rauf, Syed Uzair Ali Shah, Ahmed M. Shawky, Yahya S. Al‐Awthan, Omar Bahattab, Ghias Uddin, Javeria Sabir, Mohamed A. El‐Esawi   +8 more
openalex   +1 more source