Results 61 to 70 of about 2,648,798 (264)

Prevalence of precancerous lesions in an adult population

open access: yesIndian Journal of Dental Research, 2019
Objectives: The present study aimed to identify the prevalence of precancerous lesions among an adult population in Kerala, India. Materials and Methods: A dental screening camp was organized in each district at two locations for two consecutive days to ...
Benley George   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

National Breast Screening Committee first report 1998

open access: yes, 1998
National Breast Screening Committee ...
National Breast Screening Committee
core  

Robust High-Quality HfN-HfO 2 Gate Stack for Advanced MOS Device Applications

open access: yes, 2004
10.1109/LED.2003.820649IEEE Electron Device Letters25270 ...
Kang, J.F.   +21 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Report from the 'Eccles' breast screening programme Dublin on epidemiological aspects of screening for breast cancer in Ireland

open access: yes, 1995
This report outlines the major epidemiological aspects of screening for breast cancer, drawing extensively on experience accrued at the ECCLES Breast Screening Programme over 5 years. It is not an exhaustive account of all aspects of screening.
Codd, Mary B
core  

Cost evaluation in a colorectal cancer screening programme by faecal occult blood test in the District of Florence

open access: yes, 2008
OBJECTIVES: To evaluate the direct costs of first and repeat colorectal cancer screening by immunochemical faecal occult blood testing (I-FOBT). METHODS: Florence district residents aged 50-70 were invited to undergo one-time I-FOBT every two ...
P. Mantellini   +7 more
core   +1 more source

Breast compression techniques in screening mammography – A Maltese evaluation project [PDF]

open access: yes, 2018
Introduction: In screening mammography, the radiographer should be responsible for providing mammograms of high diagnostic value, possibly without subjecting clients to a painful experience.
Naylor, Sarah   +4 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

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