Results 121 to 130 of about 33,818 (263)
The application of the fragment-based screening approach to RmlA protein and PA1645 structure
, 2014 P. aerguinosa is a serious human bacterial pathogen. This thesis describes attempts to use structural biology to identify new starting points for drugs against P.
Boulkeroua, Wassila Abdelli
core
Screening efficiency of the affinity-attenuation system form model libraries using growth selection.
, 2014 * “2-1” shows the screening efficiency for No. 2 library after one round of second-step selection.** “2-2” shows the screening efficiency for No. 2 library after two round of second-step selection.Screening efficiency of the affinity-attenuation system ...
Misato Kaishima (632658) +3 more
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Decisions about Pap tests: What influences women and providers? [PDF]
Despite the success internationally of cervical screening programs debate continues about optimal program design. This includes increasing participation rates among under-screened women, reducing unnecessary early re-screening, improving accuracy of and ...
Marion Haas +3 more
core
Developing the mortgage sector in Nigeria through the provision of long-term finance : an efficiency perspective [PDF]
, 2014 This research investigates the role of efficiency in attracting long-term finance to the mortgage sector. Within the framework of the traditional economic theory, the new institutional theory and the theory of mortgage collateral, the study ...
Johnson, Paul Femi
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
, 2015 Key Findings HPV testing is more sensitive for precancerous lesions CIN2 and CIN3 than cytology. The downside is that the transversal specificity is lower.
J. Francart +7 more
core
An assessment of efficiency in potential screening for Wilson’s disease
, 1981 SUMMARY The efficiency of screening for Wilson's disease by serum caeruloplasmin determination was assessed by analysing the epidemiologic data of 289 affected families in Japan. The estimated gene frequency was 55 x 103.
Tomohiro Saito, T Saito
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Efficient Citation Screening by Weak Classifier Ensemble*
2025 ACM/IEEE Joint Conference on Digital Libraries (JCDL)Abstract Citation screening in systematic review is time-consuming. Machine learning can help semi-automate it but faces obstacles. Each systematic review is a new dataset without initial annotations. Extreme class imbalance against irrelevant studies makes it difficult to select a good subset of samples to train a classifier. The rigid
Jiang, X., Akinseloyin, O., Palade, V.
openaire +3 more sources