Results 101 to 110 of about 33,818 (263)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

The clinical effectiveness and cost-effectiveness of screening for open angle glaucoma : a systematic review and economic evaluation [PDF]

, 2007
Objectives: To assess whether open angle glaucoma (OAG) screening meets the UK National Screening Committee criteria, to compare screening strategies with case finding, to estimate test parameters, to model estimates of cost and cost-effectiveness, and ...
Ramsay, Craig R, Burr, JM, Fraser, Cynthia Mary, Siddiqui, M.A.R., Cook, Jonathan Alistair, C Ramsay, S McPherson, Vale, L., R Wormald, Fraser, C., Wormald, R, K Rabindranath, Wormald, R., Lourenco, T, Ramsay, C, Grant, A, Cook, J, Mowatt, G, Fraser, C, Deeks, J, J Burr, Hernández, R, Cook, J., Vale, L, Burr, Jennifer Margaret, Burr, J.M., Hernández, R., Azuara-Blanco, A, Azuara-Blanco, Augusto, Hernández, Rodolfo Andrés, Vale, Luke David, Deeks, J., Mowatt, Graham, Azuara-Blanco, A.; id_orcid, McPherson, S, L Vale, A Azuara-Blanco, McPherson, S., M Siddiqui, T Lourenco, Mowatt, G., R Hernández, Grant, A., Rabindranath, K., C Fraser, J Cook, Lourenco, Tania, Grant, Adrian Maxwell, Cairns, J, Siddiqui, Muhammad Ardul Rehman, Cairns, J., Azuara-Blanco, A., J Deeks, Rabindranath, K, Ramsay, C., Burr, J M, Siddiqui, MA, Siddiqui, MAR, A Grant, Lourenco, T., G Mowatt, Siddiqui, M A R, J Cairns   +62 more
core   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Cost-effectiveness of screening for colorectal cancer with once-only flexible sigmoidoscopy and faecal occult blood test [PDF]

On the basis of a randomized controlled trial we estimate the cost per life-year gained for six different strategies for colorectal cancer screening. Individuals in the age group 50 to 64 years were randomly selected for either flexible sigmoidoscopy or ...
Aas, Eline
core  

OPTICAL TRANSPARENT electromagnetic shields

Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019
The examples of transparent electromagnetic high-efficiency screening shields have been analyzed, the results of measuring the screening efficiency of engineering designs consisting of a glass base and a multilayer metal-ceramic coating have been ...
A. T. Volochko, V. A. Zelenin, G. V. Markov, E. O. Narushko   +3 more
doaj  

Newborn Genetic Screening Improves the Screening Efficiency for Congenital Hypothyroidism: A Prospective Multicenter Study in China

International Journal of Neonatal Screening
Newborn congenital hypothyroidism (CH) screening has been widely used worldwide. The objective of this study was to evaluate the effectiveness of applying biochemical and gene panel sequencing as screening tests for CH and to analyze the mutation ...
Liang Ye, Yinhong Zhang, Jizhen Feng, Cidan Huang, Xiaohua Wang, Lianshu Han, Yonglan Huang, Hui Zou, Baosheng Zhu, Jingkun Miao   +9 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Artificial intelligence‐driven anticancer peptide discovery

iMetaOmics
Cancer has become a major global health threat. Despite advances in modern medicine, current therapeutic strategies still face many limitations. Anticancer peptides (ACPs), due to their high selectivity, low toxicity, and multitarget effects, have ...
Junrui Wu, Shuaiqi Ji, Kashif Iqbal Sahibzada, Mengxue Lou, Feiyu An, Wenqian Li, Jiawei Guo, Taowei Zhang, Xinyi Zhang, Yilin Chou, Henan Zhang, Hao Jin, Teng Ma, Weichi Liu, Begali Alikulov, Natalia Alekseevna Golovneva, Hooi Ling Foo, Issayeva Kuralay, Zhihong Sun, Dongqing Wei, Rina Wu   +20 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source