Results 1 to 10 of about 315 (96)

Siniperca chuatsi Rhabdovirus (SCRV)-Induced Key Pathways and Major Antiviral Genes in Fish Cells [PDF]

Microorganisms, 2022
Fish rhabdoviruses, including Siniperca chuatsi rhabdovirus (SCRV), are epidemic pathogens that harm fish aquaculture. To clarify the interactions between SCRV and its host and explore antiviral targets, the present study performed transcriptome analysis
Fei Ke, Xian-Yu Meng, Qi-Ya Zhang
doaj   +4 more sources

A Novel Protein NLRP12‐119aa that Prevents Rhabdovirus Replication by Disrupting the RNP Complex Formation [PDF]

Advanced Science
The accurate assembly of the ribonucleoprotein (RNP) complex is fundamental for the replication and transcription of rhabdoviruses, which are known for their broad pathogenic impact.
Weiwei Zheng, Xiangxiang Zhu, Tongtong Zhu, Qiang Luo, Yan Zhao, Tianjun Xu   +5 more
doaj   +3 more sources

SCRV-induced miR-365–3p inhibits viral replication by targeting OTUD7B-mediated autophagy in silver carp (Hypophthalmichthys molitrix)

Aquaculture Reports
The regulatory functions of microRNAs (miRNAs) in modulating viral pathogenesis have emerged as a pivotal research focus. Aquatic species, inhabiting ecologically distinct environments, exhibit heightened vulnerability to pathogenic challenges, posing ...
Yunhang Gao, Yuan-Huan Kang, Xiuyun Jiang   +2 more
exaly   +4 more sources

Role of asparagine biosynthesis pathway in Siniperca chuatsi rhabdovirus proliferation [PDF]

Frontiers in Microbiology, 2023
Viruses are non-living organisms that rely on host cellular metabolism to complete their life cycle. Siniperca chuatsi rhabdovirus (SCRV) has caused huge economic losses to the Chinese perch (Siniperca chuatsi) industry worldwide.
Fangying Li, Fangying Li, Xiaozhe Fu, Xia Luo, Qiang Lin, Hongru Liang, Yinjie Niu, Lihui Liu, Ningqiu Li   +8 more
doaj   +2 more sources

circMORC3-encoded novel protein negatively regulates antiviral immunity through synergizing with host gene MORC3. [PDF]

PLoS Pathogens, 2023
The protein-coding ability of circRNAs has recently been a hot topic, but the role of protein-coding circRNAs in antiviral innate immunity of teleost fish has rarely been reported.
Linchao Wang, Weiwei Zheng, Xing Lv, Yanhong Song, Tianjun Xu   +4 more
doaj   +2 more sources

Eukaryotic translation elongation factor 1 alpha (eEF1A) inhibits Siniperca chuatsi rhabdovirus (SCRV) infection through two distinct mechanisms [PDF]

Journal of Virology, 2023
ABSTRACT Rhabdoviruses are single-stranded, negative-sense RNA viruses with broad host range, several of which are important pathogens. Compared with the rhabdoviruses infecting mammals, host factors involved in aquatic rhabdovirus infection have remained largely unknown.
Xian-Yu Meng, Qi-Qi Jiang, Xue-Dong Yu, Qi-Ya Zhang, Fei Ke   +4 more
openaire   +3 more sources

Mandarin Fish (Siniperca chuatsi) p53 Regulates Glutaminolysis Induced by Virus via the p53/miR145-5p/c-Myc Pathway in Chinese Perch Brain Cells [PDF]

Microbiology Spectrum, 2022
p53, as an important tumor suppressor protein, has recently been implicated in host antiviral defense. The present study found that the expression of mandarin fish (Siniperca chuatsi) p53 (Sc-p53) was negatively associated with infectious spleen and ...
Caimei Ye, Shangui Liu, Ningqiu Li, Shaozhi Zuo, Yinjie Niu, Qiang Lin, Hongru Liang, Xia Luo, Xiaozhe Fu   +8 more
doaj   +2 more sources

scTRIM44 Positively Regulated Siniperca Chuatsi Rhabdovirus Through RIG-I- and MDA5-Mediated Interferon Signaling [PDF]

Viruses
Tripartite Motif-Containing 44 (TRIM44) is responsible for cancers, neurodegenerative diseases, and viral infections. However, the role of Siniperca chuatsi TRIM44 (scTRIM44) during viral infection remains unclear.
Yinjie Niu, Xinmei Yang, Hongru Liang, Xia Luo, Baofu Ma, Qiang Lin, Xiaozhe Fu, Ningqiu Li   +7 more
doaj   +2 more sources

Oxygen-Sensing Protein Cysteamine Dioxygenase from Mandarin Fish Involved in the Arg/N-Degron Pathway and Siniperca chuatsi Rhabdovirus Infection [PDF]

Viruses, 2023
Mammalia cysteamine (2-aminoethanethiol) dioxygenase (ADO) controls the stability of the regulator of G protein signaling 4 (RGS4) through the Cys branch of the Arg/N-degron pathway, thereby affecting the response of the body to hypoxia.
Wenhui Liu, Jian He, Zhimin Li, Shaoping Weng, Changjun Guo, Jianguo He   +5 more
doaj   +2 more sources

Siniperca chuatsi rhabdovirus (SCRV) induces autophagy via PI3K/Akt-mTOR pathway in CPB cells

Fish and Shellfish Immunology, 2020
Autophagy is an important mechanism for organisms to eliminate viruses and other intracellular pathogens. Siniperca chuatsi rhabdovirus (SCRV) is an agent that has caused devastating losses in Chinese perch (Siniperca chuatsi) industry. But the role of autophagy in Siniperca chuatsi rhabdovirus (SCRV) infection is not clearly understood. In this study,
Qiang Lin, Yinjie Niu, Chen Li
exaly   +3 more sources