Results 1 to 10 of about 206 (99)

Siniperca chuatsi Rhabdovirus (SCRV)-Induced Key Pathways and Major Antiviral Genes in Fish Cells

Microorganisms, 2022
Fish rhabdoviruses, including Siniperca chuatsi rhabdovirus (SCRV), are epidemic pathogens that harm fish aquaculture. To clarify the interactions between SCRV and its host and explore antiviral targets, the present study performed transcriptome analysis
Fei Ke, Xian-Yu Meng, Qi-Ya Zhang
doaj   +4 more sources

SCRV-Induced miR-365–3p Inhibits Viral Replication by Targeting OTUD7B-Mediated Autophagy in Silver Carp (Hypophthalmichthys molitrix)

Aquaculture Reports
The regulatory functions of microRNAs (miRNAs) in modulating viral pathogenesis have emerged as a pivotal research focus. Aquatic species, inhabiting ecologically distinct environments, exhibit heightened vulnerability to pathogenic challenges, posing ...
Yunhang Gao, Yiming Wei
exaly   +4 more sources

Autophagy Delays Apoptotic Cell Death Induced by Siniperca chuatsi Rhabdovirus in Epithelioma Papulosum Cyprinid Cells

Viruses, 2021
Autophagy and apoptosis are two key cell fate determination pathways, which play vital roles in the interaction between viruses and host cells. Previous research had confirmed that one strain of fish rhabdoviruses, Siniperca chuatsi rhabdovirus (SCRV ...
Guang-Zhou Zhou, Jun Li, Yan-He Sun, Qin Zhang, Lu Zhang, Chao Pei   +5 more
doaj   +2 more sources

Role of Asparagine Biosynthesis Pathway in Siniperca chuatsi Rhabdovirus Proliferation

Frontiers in Microbiology, 2023
Viruses are non-living organisms that rely on host cellular metabolism to complete their life cycle. Siniperca chuatsi rhabdovirus (SCRV) has caused huge economic losses to the Chinese perch (Siniperca chuatsi) industry worldwide.
Qiang Lin, Yinjie Niu, Ningqiu Li
exaly   +3 more sources

Siniperca chuatsi Rhabdovirus (SCRV) Induces Autophagy via PI3K/Akt-mTOR Pathway in CPB Cells

Fish and Shellfish Immunology, 2020
Autophagy is an important mechanism for organisms to eliminate viruses and other intracellular pathogens. Siniperca chuatsi rhabdovirus (SCRV) is an agent that has caused devastating losses in Chinese perch (Siniperca chuatsi) industry. But the role of autophagy in Siniperca chuatsi rhabdovirus (SCRV) infection is not clearly understood. In this study,
Qiang Lin, Yinjie Niu, Chen Li
exaly   +3 more sources

Long Noncoding RNA MIR122HG Inhibits MAVS-Mediated Antiviral Immune Response by Deriving miR-122 in Miiuy Croaker (Miichthys miiuy)

Viruses, 2022
Long noncoding RNAs (lncRNAs) function as micro regulators to impact gene expression after multiple pathogen infections, which have been largely studied in the last few years. Although lncRNA studies on lower vertebrates have received less attention than
Junxia Cui, Weiwei Zheng, Tianjun Xu, Yuena Sun   +3 more
doaj   +2 more sources

Transcriptomic Profiling of the Immune Response to Siniperca chuatsi Rhabdovirus (SCRV) in E11 Cells

Aquaculture International
Abstract Siniperca chuatsi rhabdovirus (SCRV) has caused severe disease and mortality in commercial fish in China. To investigate the molecular relationships between pathogen and host, transcriptome analysis of SCRV-infected and non-infected E11 cells was obtained using the Illumina HiSeq X Ten sequencing system.
Xiaodan Liu, Yanbing Zhang
exaly   +2 more sources

Mandarin Fish (Siniperca chuatsi) p53 Regulates Glutaminolysis Induced by Virus via the p53/miR145-5p/c-Myc Pathway in Chinese Perch Brain Cells

Microbiology Spectrum, 2022
p53, as an important tumor suppressor protein, has recently been implicated in host antiviral defense. The present study found that the expression of mandarin fish (Siniperca chuatsi) p53 (Sc-p53) was negatively associated with infectious spleen and ...
Caimei Ye, Shangui Liu, Ningqiu Li, Shaozhi Zuo, Yinjie Niu, Qiang Lin, Hongru Liang, Xia Luo, Xiaozhe Fu   +8 more
doaj   +1 more source

The Sp1-Responsive microRNA-15b Negatively Regulates Rhabdovirus-Triggered Innate Immune Responses in Lower Vertebrates by Targeting TBK1

Frontiers in Immunology, 2021
As is known to all, the production of type I interferon (IFN) plays pivotal roles in host innate antiviral immunity, and its moderate production play a positive role in promoting the activation of host innate antiviral immune response. However, the virus
Renjie Chang, Renjie Chang, Qing Chu, Qing Chu, Weiwei Zheng, Weiwei Zheng, Weiwei Zheng, Lei Zhang, Tianjun Xu, Tianjun Xu, Tianjun Xu, Tianjun Xu   +11 more
doaj   +1 more source

circMORC3-encoded novel protein negatively regulates antiviral immunity through synergizing with host gene MORC3.

PLoS Pathogens, 2023
The protein-coding ability of circRNAs has recently been a hot topic, but the role of protein-coding circRNAs in antiviral innate immunity of teleost fish has rarely been reported.
Linchao Wang, Weiwei Zheng, Xing Lv, Yanhong Song, Tianjun Xu   +4 more
doaj   +1 more source