Results 231 to 240 of about 11,884,091 (288)

Network based approach identifies miR‐145‐3p as a central regulatory hub associated to the progression from localized to metastatic medullary thyroid carcinoma

open access: yesThe Journal of Pathology, Volume 270, Issue 4, Page 468-480, December 2026.
Abstract Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor originating from calcitonin producing C‐cells and accounts for 1–5% of thyroid cancers. Total thyroidectomy is curative in localized disease (N0), whereas lymph node metastases (N1) are associated with poorer prognosis.
Anna Citarella   +24 more
wiley   +1 more source

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 11143-11177, December 2026.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding   +4 more
wiley   +1 more source

When People Meet Floods: Time‐Varying Population Exposure to Urban Pluvial Flooding in Rome, Italy

open access: yesJournal of Flood Risk Management, Volume 19, Issue 4, December 2026.
This study introduces a time‐varying urban flood risk framework that accounts for daily mobility and scheduled events. By capturing spatiotemporal shifts in exposure, the approach generates actionable, time‐explicit insights, enabling Civil Protection to transition from static baselines to dynamic, location‐ and time‐specific emergency response ...
Edna Jessica Wilches Kochinski   +5 more
wiley   +1 more source

Evaporation Kinetics Engineering Suppressed Bimolecular Recombination in All‐Polymer Solar Cells

open access: yesAdvanced Science, Volume 13, Issue 61, 3 November 2026.
In this study, phenanthrene (Ph), a volatile solid additive with a weak tendency toward self‐aggregation, is introduced as a donor‐selective morphology regulator in benchmark all‐PSC systems. The moderate evaporation kinetics of Ph enable cooperative crystallization of donors and acceptors, leading to an increased fractal dimension with reduced donor ...
Dinglong Feng   +17 more
wiley   +1 more source

Design storm estimation for flood risk assessment in the temperate Himalayan basin using hydrological modelling. [PDF]

open access: yesSci Rep
Attar MI   +8 more
europepmc   +1 more source

Targeting B‐Cell‐Activating Factor and Its Receptor in Immune Thrombocytopenia and Warm Autoimmune Hemolytic Anemia

open access: yesAmerican Journal of Hematology, Volume 101, Issue 11, Page 2836-2852, November 2026.
ABSTRACT Current treatments for immune thrombocytopenia (ITP) and warm autoimmune hemolytic anemia (wAIHA), rare autoimmune diseases in which autoreactive B cells play a major role, can lead to high response rates; however, for many patients these responses are not durable or maintained after treatment discontinuation.
Matthieu Mahévas   +4 more
wiley   +1 more source

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